Acute bulbar palsy as a variant of Guillain-Barré syndrome

Korean Inflammatory Neuropathy Consortium

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To categorize a syndrome manifesting as prominent acute bulbar palsy (ABP) without limb motor weakness as a variant form of Guillain-Barré syndrome (GBS) and differentiate it from Miller Fisher syndrome (MFS) and pharyngeal-cervical-brachial (PCB) variants. Methods: We analyzed cases of ABP without limb motor weakness based on a dataset containing clinical information and the results of antiganglioside antibodies assays for acute immune-mediated neuropathies. Results: Eleven cases with an age at onset ranging from 18 to 65 years (mean 33.8 years) were identified as ABP-plus syndrome. All of the enrolled cases manifested with ABP as the predominant symptom, and with no limb weakness. The following features accompanied ABP in order of decreasing frequency: ophthalmoplegia (n 9, 82%), ataxia (n 9, 82%), and facial palsy (n 6, 55%). An enzyme-linked immunosorbent assay study disclosed that immunoglobulin G (IgG) anti-GT1a antibodies were the most frequent (n 11), followed by IgG anti-GQ1b antibodies (n 6). Conclusions: We propose that ABP-plus syndrome without neck or limb weakness is a variant of GBS that is distinct from the MFS and PCB variants. The presence of IgG anti-GT1a antibodies can explain the relationships between the distinct clinical characteristics and the underlying pathomechanisms.

Original languageEnglish
Pages (from-to)742-747
Number of pages6
JournalNeurology
Volume86
Issue number8
DOIs
Publication statusPublished - 2016 Feb 23

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Progressive Bulbar Palsy
Extremities
Miller Fisher Syndrome
Anti-Idiotypic Antibodies
Immunoglobulin G
Arm
Ophthalmoplegia
Facial Paralysis
Ataxia
Age of Onset
Neck
Enzyme-Linked Immunosorbent Assay
Antibodies

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Acute bulbar palsy as a variant of Guillain-Barré syndrome. / Korean Inflammatory Neuropathy Consortium.

In: Neurology, Vol. 86, No. 8, 23.02.2016, p. 742-747.

Research output: Contribution to journalArticle

Korean Inflammatory Neuropathy Consortium 2016, 'Acute bulbar palsy as a variant of Guillain-Barré syndrome', Neurology, vol. 86, no. 8, pp. 742-747. https://doi.org/10.1212/WNL.0000000000002256
Korean Inflammatory Neuropathy Consortium. / Acute bulbar palsy as a variant of Guillain-Barré syndrome. In: Neurology. 2016 ; Vol. 86, No. 8. pp. 742-747.
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AU - Shin, Ha Young

AU - Shin, Kyong Jin

AU - Nam, Tai Seung

AU - Oh, Jeeyoung

AU - Suh, Bum Chun

AU - Yoon, Byeol A.

AU - Park, Hwan Tae

AU - Huh, So Young

AU - Oh, Seong Il

AU - Bae, Jong Seok

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