Acute effect of high-dose isoflavones from Pueraria lobata (willd.) Ohwi on lipid and bone metabolism in ovariectomized mice

Hee Joon Cho, Hee Jin Jun, Ji Hae Lee, Yaoyao Jia, Minh Hien Hoang, Jae Hoon Shim, Kwan Hwa Park, Sung Joon Lee

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Abstract

We investigated the acute metabolic effects of isoflavones from Pueraria lobata (Willd.) Ohwi (IPL) in ovariectomized (OVX) mice. After 4 weeks of IPL feeding at 500 mg/day/kg body weight (OVX500), plasma 17β-estradiol concentrations were significantly higher (+25%, p < 0.05), whereas plasma triglyceride levels were significantly lower in OVX mice (-15%, p < 0.05) compared with controls. Abdominal adipose tissue weight was marginally reduced in IPL-fed groups compared with OVX controls and the plasma levels of liver enzymes were unchanged. In addition, IPL significantly inhibited the reduction of bone mineral density in the femurs of OVX mice (OVX200, +22%; OVX500, +26%; p < 0.05) compared with controls after 4 weeks of IPL feeding. In quantitative polymerase chain reaction analysis the expression of aromatase was significantly suppressed and SULT1E1 was increased by IPL feeding, showing that IPL feeding may not alter the risk for breast cancer in mice. Our results suggest that IPL could ameliorate menopausal symptoms in mice. Further studies will confirm the effects of IPL in humans.

Original languageEnglish
Pages (from-to)1864-1871
Number of pages8
JournalPhytotherapy Research
Volume26
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

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Keywords

  • Pueraria lobata (Willd.) Ohwi
  • bone
  • lipid metabolism
  • ovariectomy
  • puerarin

ASJC Scopus subject areas

  • Pharmacology

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