Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor

Keunhee Kang, Joo Hee Park, Ja Young Ryu, Sang Yup Lee, Gang Jee Ko, Young-Joo Kwon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Paraneoplastic leukocytosis was defined as elevated white blood cell (WBC) levels caused by cytokines, likely produced by the tumor itself, without evidence of infection or myeloproliferative disease. We report a case of anaplastic thyroid carcinoma with leukocytosis caused by elevated production of granulocyte colony-stimulating factor (G-CSF) by the carcinoma. Initially, acute pyelonephritis (APN) was diagnosed and treatment for APN was ongoing, but the WBC count steadily increased to 68.8×109/L. She was diagnosed with anaplastic thyroid carcinoma on her neck mass, and the serum concentration of G-CSF was found to be markedly increased at 1,010 pg/mL. In spite of supportive care, the patient's condition rapidly deteriorated and the patient died on day 23 of hospital stay.Leukocytosis without definite evidence of infection could be a paraneoplastic manifestation in patients with malignant tumors, and paraneoplastic leukocytosis may be related to poor prognosis.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalBlood Research
Volume48
Issue number1
DOIs
Publication statusPublished - 2013 Dec 24

Fingerprint

Pyelonephritis
Leukocytosis
Granulocyte Colony-Stimulating Factor
Infection
Leukocyte Count
Length of Stay
Neoplasms
Patient Care
Leukocytes
Neck
Cytokines
Carcinoma
Anaplastic Thyroid Carcinoma
Serum
Therapeutics

Keywords

  • Anaplastic thyroid carcinoma
  • G-CSF
  • Paraneoplastic leukocytosis

ASJC Scopus subject areas

  • Hematology

Cite this

Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor. / Kang, Keunhee; Park, Joo Hee; Ryu, Ja Young; Lee, Sang Yup; Ko, Gang Jee; Kwon, Young-Joo.

In: Blood Research, Vol. 48, No. 1, 24.12.2013, p. 63-66.

Research output: Contribution to journalArticle

Kang, Keunhee ; Park, Joo Hee ; Ryu, Ja Young ; Lee, Sang Yup ; Ko, Gang Jee ; Kwon, Young-Joo. / Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor. In: Blood Research. 2013 ; Vol. 48, No. 1. pp. 63-66.
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