Abstract
Paraneoplastic leukocytosis was defined as elevated white blood cell (WBC) levels caused by cytokines, likely produced by the tumor itself, without evidence of infection or myeloproliferative disease. We report a case of anaplastic thyroid carcinoma with leukocytosis caused by elevated production of granulocyte colony-stimulating factor (G-CSF) by the carcinoma. Initially, acute pyelonephritis (APN) was diagnosed and treatment for APN was ongoing, but the WBC count steadily increased to 68.8×109/L. She was diagnosed with anaplastic thyroid carcinoma on her neck mass, and the serum concentration of G-CSF was found to be markedly increased at 1,010 pg/mL. In spite of supportive care, the patient's condition rapidly deteriorated and the patient died on day 23 of hospital stay.Leukocytosis without definite evidence of infection could be a paraneoplastic manifestation in patients with malignant tumors, and paraneoplastic leukocytosis may be related to poor prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 63-66 |
| Number of pages | 4 |
| Journal | Blood Research |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2013 Dec 24 |
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Keywords
- Anaplastic thyroid carcinoma
- G-CSF
- Paraneoplastic leukocytosis
ASJC Scopus subject areas
- Hematology
Cite this
Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor. / Kang, Keunhee; Park, Joo Hee; Ryu, Ja Young; Lee, Sang Yup; Ko, Gang Jee; Kwon, Young-Joo.
In: Blood Research, Vol. 48, No. 1, 24.12.2013, p. 63-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute pyelonephritis with anaplastic thyroid carcinoma producing granulocyte colony-stimulating factor
AU - Kang, Keunhee
AU - Park, Joo Hee
AU - Ryu, Ja Young
AU - Lee, Sang Yup
AU - Ko, Gang Jee
AU - Kwon, Young-Joo
PY - 2013/12/24
Y1 - 2013/12/24
N2 - Paraneoplastic leukocytosis was defined as elevated white blood cell (WBC) levels caused by cytokines, likely produced by the tumor itself, without evidence of infection or myeloproliferative disease. We report a case of anaplastic thyroid carcinoma with leukocytosis caused by elevated production of granulocyte colony-stimulating factor (G-CSF) by the carcinoma. Initially, acute pyelonephritis (APN) was diagnosed and treatment for APN was ongoing, but the WBC count steadily increased to 68.8×109/L. She was diagnosed with anaplastic thyroid carcinoma on her neck mass, and the serum concentration of G-CSF was found to be markedly increased at 1,010 pg/mL. In spite of supportive care, the patient's condition rapidly deteriorated and the patient died on day 23 of hospital stay.Leukocytosis without definite evidence of infection could be a paraneoplastic manifestation in patients with malignant tumors, and paraneoplastic leukocytosis may be related to poor prognosis.
AB - Paraneoplastic leukocytosis was defined as elevated white blood cell (WBC) levels caused by cytokines, likely produced by the tumor itself, without evidence of infection or myeloproliferative disease. We report a case of anaplastic thyroid carcinoma with leukocytosis caused by elevated production of granulocyte colony-stimulating factor (G-CSF) by the carcinoma. Initially, acute pyelonephritis (APN) was diagnosed and treatment for APN was ongoing, but the WBC count steadily increased to 68.8×109/L. She was diagnosed with anaplastic thyroid carcinoma on her neck mass, and the serum concentration of G-CSF was found to be markedly increased at 1,010 pg/mL. In spite of supportive care, the patient's condition rapidly deteriorated and the patient died on day 23 of hospital stay.Leukocytosis without definite evidence of infection could be a paraneoplastic manifestation in patients with malignant tumors, and paraneoplastic leukocytosis may be related to poor prognosis.
KW - Anaplastic thyroid carcinoma
KW - G-CSF
KW - Paraneoplastic leukocytosis
UR - http://www.scopus.com/inward/record.url?scp=84890694262&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890694262&partnerID=8YFLogxK
U2 - 10.5045/br.2013.48.1.63
DO - 10.5045/br.2013.48.1.63
M3 - Article
AN - SCOPUS:84890694262
VL - 48
SP - 63
EP - 66
JO - Blood Research
JF - Blood Research
SN - 2287-979X
IS - 1
ER -