Acute respiratory distress syndrome caused by miliary tuberculosis

A multicentre survey in South Korea

K. Lee, Je Hyeong Kim, J. H. Lee, W. Y. Lee, M. S. Park, J. Y. Kim, K. C. Kim, M. G. Lee, K. S. Jung, Y. S. Kim, Y. M. Shin, Younsuck Koh

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

BACKGROUND: Miliary tuberculosis (TB) is an unusual cause of acute respiratory distress syndrome (ARDS). OBJECTIVE: To evaluate the clinical characteristics and outcomes of patients with ARDS caused by miliary TB admitted to the intensive care unit (ICU). DESIGN: A total of 67 patients were enrolled during the period 1999-2008. RESULTS: The median age of the patients was 56 years (range 17-81), 19 (28.4%) were aged >71 years, and 38 (56.7%) were male. All-cause mortality in the ICU and hospital were respectively 58.2% and 61.2%. Of the total number of enrolled patients, 49 (73.1%) were prescribed anti-tuberculosis medication within 3 days of hospital admission. On the day of ARDS diagnosis (10.0 ± 3.7 vs. 7.4 ± 3.5, P = 0.005), non-survivors had a significantly higher Sequential Organ Failure Assessment (SOFA) score than survivors. Multivariate analysis showed that SOFA score on the day of ARDS diagnosis was a significant predictor of survival (OR 0.809, 95%CI 0.691-0.946, P = 0.008). It was difficult to determine the efficacy of systemic corticosteroids on patient survival. CONCLUSION: ARDS caused by miliary TB was associated with a high in-hospital mortality rate, with SOFA score on the day of ARDS diagnosis being a valuable prognostic indicator.

Original languageEnglish
Pages (from-to)1099-1103
Number of pages5
JournalInternational Journal of Tuberculosis and Lung Disease
Volume15
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1

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Miliary Tuberculosis
Republic of Korea
Adult Respiratory Distress Syndrome
Organ Dysfunction Scores
Intensive Care Units
Survival
Mortality
Hospital Mortality
Survivors
Surveys and Questionnaires
Adrenal Cortex Hormones
Tuberculosis
Multivariate Analysis

Keywords

  • Acute respiratory distress syndrome
  • Miliary tuberculosis
  • South Korea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Acute respiratory distress syndrome caused by miliary tuberculosis : A multicentre survey in South Korea. / Lee, K.; Kim, Je Hyeong; Lee, J. H.; Lee, W. Y.; Park, M. S.; Kim, J. Y.; Kim, K. C.; Lee, M. G.; Jung, K. S.; Kim, Y. S.; Shin, Y. M.; Koh, Younsuck.

In: International Journal of Tuberculosis and Lung Disease, Vol. 15, No. 8, 01.08.2011, p. 1099-1103.

Research output: Contribution to journalArticle

Lee, K, Kim, JH, Lee, JH, Lee, WY, Park, MS, Kim, JY, Kim, KC, Lee, MG, Jung, KS, Kim, YS, Shin, YM & Koh, Y 2011, 'Acute respiratory distress syndrome caused by miliary tuberculosis: A multicentre survey in South Korea', International Journal of Tuberculosis and Lung Disease, vol. 15, no. 8, pp. 1099-1103. https://doi.org/10.5588/ijtld.10.0557
Lee, K. ; Kim, Je Hyeong ; Lee, J. H. ; Lee, W. Y. ; Park, M. S. ; Kim, J. Y. ; Kim, K. C. ; Lee, M. G. ; Jung, K. S. ; Kim, Y. S. ; Shin, Y. M. ; Koh, Younsuck. / Acute respiratory distress syndrome caused by miliary tuberculosis : A multicentre survey in South Korea. In: International Journal of Tuberculosis and Lung Disease. 2011 ; Vol. 15, No. 8. pp. 1099-1103.
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abstract = "BACKGROUND: Miliary tuberculosis (TB) is an unusual cause of acute respiratory distress syndrome (ARDS). OBJECTIVE: To evaluate the clinical characteristics and outcomes of patients with ARDS caused by miliary TB admitted to the intensive care unit (ICU). DESIGN: A total of 67 patients were enrolled during the period 1999-2008. RESULTS: The median age of the patients was 56 years (range 17-81), 19 (28.4{\%}) were aged >71 years, and 38 (56.7{\%}) were male. All-cause mortality in the ICU and hospital were respectively 58.2{\%} and 61.2{\%}. Of the total number of enrolled patients, 49 (73.1{\%}) were prescribed anti-tuberculosis medication within 3 days of hospital admission. On the day of ARDS diagnosis (10.0 ± 3.7 vs. 7.4 ± 3.5, P = 0.005), non-survivors had a significantly higher Sequential Organ Failure Assessment (SOFA) score than survivors. Multivariate analysis showed that SOFA score on the day of ARDS diagnosis was a significant predictor of survival (OR 0.809, 95{\%}CI 0.691-0.946, P = 0.008). It was difficult to determine the efficacy of systemic corticosteroids on patient survival. CONCLUSION: ARDS caused by miliary TB was associated with a high in-hospital mortality rate, with SOFA score on the day of ARDS diagnosis being a valuable prognostic indicator.",
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