Abstract
BACKGROUND: Miliary tuberculosis (TB) is an unusual cause of acute respiratory distress syndrome (ARDS). OBJECTIVE: To evaluate the clinical characteristics and outcomes of patients with ARDS caused by miliary TB admitted to the intensive care unit (ICU). DESIGN: A total of 67 patients were enrolled during the period 1999-2008. RESULTS: The median age of the patients was 56 years (range 17-81), 19 (28.4%) were aged >71 years, and 38 (56.7%) were male. All-cause mortality in the ICU and hospital were respectively 58.2% and 61.2%. Of the total number of enrolled patients, 49 (73.1%) were prescribed anti-tuberculosis medication within 3 days of hospital admission. On the day of ARDS diagnosis (10.0 ± 3.7 vs. 7.4 ± 3.5, P = 0.005), non-survivors had a significantly higher Sequential Organ Failure Assessment (SOFA) score than survivors. Multivariate analysis showed that SOFA score on the day of ARDS diagnosis was a significant predictor of survival (OR 0.809, 95%CI 0.691-0.946, P = 0.008). It was difficult to determine the efficacy of systemic corticosteroids on patient survival. CONCLUSION: ARDS caused by miliary TB was associated with a high in-hospital mortality rate, with SOFA score on the day of ARDS diagnosis being a valuable prognostic indicator.
| Original language | English |
|---|---|
| Pages (from-to) | 1099-1103 |
| Number of pages | 5 |
| Journal | International Journal of Tuberculosis and Lung Disease |
| Volume | 15 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2011 Aug 1 |
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Keywords
- Acute respiratory distress syndrome
- Miliary tuberculosis
- South Korea
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Infectious Diseases
Cite this
Acute respiratory distress syndrome caused by miliary tuberculosis : A multicentre survey in South Korea. / Lee, K.; Kim, Je Hyeong; Lee, J. H.; Lee, W. Y.; Park, M. S.; Kim, J. Y.; Kim, K. C.; Lee, M. G.; Jung, K. S.; Kim, Y. S.; Shin, Y. M.; Koh, Younsuck.
In: International Journal of Tuberculosis and Lung Disease, Vol. 15, No. 8, 01.08.2011, p. 1099-1103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute respiratory distress syndrome caused by miliary tuberculosis
T2 - A multicentre survey in South Korea
AU - Lee, K.
AU - Kim, Je Hyeong
AU - Lee, J. H.
AU - Lee, W. Y.
AU - Park, M. S.
AU - Kim, J. Y.
AU - Kim, K. C.
AU - Lee, M. G.
AU - Jung, K. S.
AU - Kim, Y. S.
AU - Shin, Y. M.
AU - Koh, Younsuck
PY - 2011/8/1
Y1 - 2011/8/1
N2 - BACKGROUND: Miliary tuberculosis (TB) is an unusual cause of acute respiratory distress syndrome (ARDS). OBJECTIVE: To evaluate the clinical characteristics and outcomes of patients with ARDS caused by miliary TB admitted to the intensive care unit (ICU). DESIGN: A total of 67 patients were enrolled during the period 1999-2008. RESULTS: The median age of the patients was 56 years (range 17-81), 19 (28.4%) were aged >71 years, and 38 (56.7%) were male. All-cause mortality in the ICU and hospital were respectively 58.2% and 61.2%. Of the total number of enrolled patients, 49 (73.1%) were prescribed anti-tuberculosis medication within 3 days of hospital admission. On the day of ARDS diagnosis (10.0 ± 3.7 vs. 7.4 ± 3.5, P = 0.005), non-survivors had a significantly higher Sequential Organ Failure Assessment (SOFA) score than survivors. Multivariate analysis showed that SOFA score on the day of ARDS diagnosis was a significant predictor of survival (OR 0.809, 95%CI 0.691-0.946, P = 0.008). It was difficult to determine the efficacy of systemic corticosteroids on patient survival. CONCLUSION: ARDS caused by miliary TB was associated with a high in-hospital mortality rate, with SOFA score on the day of ARDS diagnosis being a valuable prognostic indicator.
AB - BACKGROUND: Miliary tuberculosis (TB) is an unusual cause of acute respiratory distress syndrome (ARDS). OBJECTIVE: To evaluate the clinical characteristics and outcomes of patients with ARDS caused by miliary TB admitted to the intensive care unit (ICU). DESIGN: A total of 67 patients were enrolled during the period 1999-2008. RESULTS: The median age of the patients was 56 years (range 17-81), 19 (28.4%) were aged >71 years, and 38 (56.7%) were male. All-cause mortality in the ICU and hospital were respectively 58.2% and 61.2%. Of the total number of enrolled patients, 49 (73.1%) were prescribed anti-tuberculosis medication within 3 days of hospital admission. On the day of ARDS diagnosis (10.0 ± 3.7 vs. 7.4 ± 3.5, P = 0.005), non-survivors had a significantly higher Sequential Organ Failure Assessment (SOFA) score than survivors. Multivariate analysis showed that SOFA score on the day of ARDS diagnosis was a significant predictor of survival (OR 0.809, 95%CI 0.691-0.946, P = 0.008). It was difficult to determine the efficacy of systemic corticosteroids on patient survival. CONCLUSION: ARDS caused by miliary TB was associated with a high in-hospital mortality rate, with SOFA score on the day of ARDS diagnosis being a valuable prognostic indicator.
KW - Acute respiratory distress syndrome
KW - Miliary tuberculosis
KW - South Korea
UR - http://www.scopus.com/inward/record.url?scp=79960400912&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960400912&partnerID=8YFLogxK
U2 - 10.5588/ijtld.10.0557
DO - 10.5588/ijtld.10.0557
M3 - Article
VL - 15
SP - 1099
EP - 1103
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
SN - 1027-3719
IS - 8
ER -