Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.

Garry Whitehead, Jihoon Jo, Ellen L. Hogg, Thomas Piers, Dong Hyun Kim, Gillian Seaton, Heon Seok, Gilles Bru-Mercier, Gi Hoon Son, Philip Regan, Lars Hildebrandt, Eleanor Waite, Byeong Chae Kim, Talitha L. Kerrigan, Kyungjin Kim, Daniel J. Whitcomb, Graham L. Collingridge, Stafford L. Lightman, Kwangwook Cho

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The neuroendocrine response to episodes of acute stress is crucial for survival whereas the prolonged response to chronic stress can be detrimental. Learning and memory are particularly susceptible to stress with cognitive deficits being well characterized consequences of chronic stress. Although there is good evidence that acute stress can enhance cognitive performance, the mechanism(s) for this are unclear. We find that hippocampal slices, either prepared from rats following 30 min restraint stress or directly exposed to glucocorticoids, exhibit an N-methyl-d-aspartic acid receptor-independent form of long-term potentiation. We demonstrate that the mechanism involves an NMDA receptor and PKA-dependent insertion of Ca2+ -permeable AMPA receptors into synapses. These then trigger the additional NMDA receptor-independent form of LTP during high frequency stimulation.

Original languageEnglish
Pages (from-to)3753-3765
Number of pages13
JournalBrain : a journal of neurology
Volume136
Issue numberPt 12
Publication statusPublished - 2013 Dec 1

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AMPA Receptors
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
Hippocampus
Synapses
Glucocorticoids
Learning
aspartic acid receptor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Whitehead, G., Jo, J., Hogg, E. L., Piers, T., Kim, D. H., Seaton, G., ... Cho, K. (2013). Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus. Brain : a journal of neurology, 136(Pt 12), 3753-3765.

Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus. / Whitehead, Garry; Jo, Jihoon; Hogg, Ellen L.; Piers, Thomas; Kim, Dong Hyun; Seaton, Gillian; Seok, Heon; Bru-Mercier, Gilles; Son, Gi Hoon; Regan, Philip; Hildebrandt, Lars; Waite, Eleanor; Kim, Byeong Chae; Kerrigan, Talitha L.; Kim, Kyungjin; Whitcomb, Daniel J.; Collingridge, Graham L.; Lightman, Stafford L.; Cho, Kwangwook.

In: Brain : a journal of neurology, Vol. 136, No. Pt 12, 01.12.2013, p. 3753-3765.

Research output: Contribution to journalArticle

Whitehead, G, Jo, J, Hogg, EL, Piers, T, Kim, DH, Seaton, G, Seok, H, Bru-Mercier, G, Son, GH, Regan, P, Hildebrandt, L, Waite, E, Kim, BC, Kerrigan, TL, Kim, K, Whitcomb, DJ, Collingridge, GL, Lightman, SL & Cho, K 2013, 'Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.', Brain : a journal of neurology, vol. 136, no. Pt 12, pp. 3753-3765.
Whitehead, Garry ; Jo, Jihoon ; Hogg, Ellen L. ; Piers, Thomas ; Kim, Dong Hyun ; Seaton, Gillian ; Seok, Heon ; Bru-Mercier, Gilles ; Son, Gi Hoon ; Regan, Philip ; Hildebrandt, Lars ; Waite, Eleanor ; Kim, Byeong Chae ; Kerrigan, Talitha L. ; Kim, Kyungjin ; Whitcomb, Daniel J. ; Collingridge, Graham L. ; Lightman, Stafford L. ; Cho, Kwangwook. / Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus. In: Brain : a journal of neurology. 2013 ; Vol. 136, No. Pt 12. pp. 3753-3765.
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