Acute/subacute toxicity of nano calcium

Eun Young Jung, Hyung Joo Suh

Research output: Contribution to journalArticle

Abstract

The objective of this study was to obtain data on the safety-in-use of nano calcium as a dietary supplement by assessing its acute and subacute oral toxicities in female and male Sprague-Dawley rats. A single oral dose of 5,000 mg/kg of nano calcium did not result in mortality or significant changes in the general behavior and gross appearance of the internal organs of rats. For subacute toxicity study, nano calcium was administered orally at a dose of 1,000 mg/kg daily for 14 days. There were no significant differences in organ weights between control and treated groups of both sexes. Hematological analysis and blood chemistry revealed no toxic effects of nano calcium. Pathologically, neither gross abnormalities nor histopathological changes were observed. These results show that nano calcium possesses very low toxicity as indicated in a rat model.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of the Korean Society of Food Science and Nutrition
Volume44
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

subacute toxicity
acute toxicity
Calcium
calcium
drug toxicity
blood chemistry
Organ Size
Poisons
rats
dosage
tissue weight
Dietary Supplements
toxicity testing
Sprague Dawley Rats
dietary supplements
mouth
animal models
toxicity
Safety
Control Groups

Keywords

  • Acute toxicity
  • Egg shell calcium
  • Nano calcium
  • Subacute toxicity

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Food Science

Cite this

Acute/subacute toxicity of nano calcium. / Jung, Eun Young; Suh, Hyung Joo.

In: Journal of the Korean Society of Food Science and Nutrition, Vol. 44, No. 1, 01.01.2015, p. 29-34.

Research output: Contribution to journalArticle

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