Additional amplifications of SERS via an optofluidic CD-based platform

Dukhyun Choi, Taewook Kang, Hansang Cho, Yeonho Choi, Luke P. Lee

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

In this paper, signal amplifications of surface-enhanced Raman scattering (SERS) are realized by an optofluidic compact disc (CD)-based preconcentration method for effective label-free environmental and biomolecular detections. The preconcentration of target molecules is accomplished through the accumulation of adsorbed molecules on SERS-active sites by repeating a 'filling-drying' cycle of the assay solution in the optofluidic CD platform. After 30 cycles, the clear and high SERS signal of rhodamine 6G of 1 nM is readily detected. In addition to the preconcentration-based signal amplification by the optofluidic SERS system on the CD platform, we introduce a controlled precipitation of gold nanoparticles by CuSO 4 for SERS substrates. This method provides high-throughput, high-sensitive and large-area uniform SERS substrates on the optofluidic CD platform. The uniform SERS signals from different positions in spots of 3 mm 2 on the different CDs gives us confidence in the reliability and stability of our SERS substrates.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalLab on a Chip - Miniaturisation for Chemistry and Biology
Volume9
Issue number2
DOIs
Publication statusPublished - 2009 Aug 10
Externally publishedYes

Fingerprint

Raman Spectrum Analysis
Amplification
Raman scattering
Substrates
Molecules
Gold
Nanoparticles
Labels
Assays
Catalytic Domain
Drying
Throughput

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Biomedical Engineering

Cite this

Additional amplifications of SERS via an optofluidic CD-based platform. / Choi, Dukhyun; Kang, Taewook; Cho, Hansang; Choi, Yeonho; Lee, Luke P.

In: Lab on a Chip - Miniaturisation for Chemistry and Biology, Vol. 9, No. 2, 10.08.2009, p. 239-243.

Research output: Contribution to journalArticle

Choi, Dukhyun ; Kang, Taewook ; Cho, Hansang ; Choi, Yeonho ; Lee, Luke P. / Additional amplifications of SERS via an optofluidic CD-based platform. In: Lab on a Chip - Miniaturisation for Chemistry and Biology. 2009 ; Vol. 9, No. 2. pp. 239-243.
@article{e48b536034a545de9613304e7329500b,
title = "Additional amplifications of SERS via an optofluidic CD-based platform",
abstract = "In this paper, signal amplifications of surface-enhanced Raman scattering (SERS) are realized by an optofluidic compact disc (CD)-based preconcentration method for effective label-free environmental and biomolecular detections. The preconcentration of target molecules is accomplished through the accumulation of adsorbed molecules on SERS-active sites by repeating a 'filling-drying' cycle of the assay solution in the optofluidic CD platform. After 30 cycles, the clear and high SERS signal of rhodamine 6G of 1 nM is readily detected. In addition to the preconcentration-based signal amplification by the optofluidic SERS system on the CD platform, we introduce a controlled precipitation of gold nanoparticles by CuSO 4 for SERS substrates. This method provides high-throughput, high-sensitive and large-area uniform SERS substrates on the optofluidic CD platform. The uniform SERS signals from different positions in spots of 3 mm 2 on the different CDs gives us confidence in the reliability and stability of our SERS substrates.",
author = "Dukhyun Choi and Taewook Kang and Hansang Cho and Yeonho Choi and Lee, {Luke P.}",
year = "2009",
month = "8",
day = "10",
doi = "10.1039/b812067f",
language = "English",
volume = "9",
pages = "239--243",
journal = "Lab on a Chip - Miniaturisation for Chemistry and Biology",
issn = "1473-0197",
publisher = "Royal Society of Chemistry",
number = "2",

}

TY - JOUR

T1 - Additional amplifications of SERS via an optofluidic CD-based platform

AU - Choi, Dukhyun

AU - Kang, Taewook

AU - Cho, Hansang

AU - Choi, Yeonho

AU - Lee, Luke P.

PY - 2009/8/10

Y1 - 2009/8/10

N2 - In this paper, signal amplifications of surface-enhanced Raman scattering (SERS) are realized by an optofluidic compact disc (CD)-based preconcentration method for effective label-free environmental and biomolecular detections. The preconcentration of target molecules is accomplished through the accumulation of adsorbed molecules on SERS-active sites by repeating a 'filling-drying' cycle of the assay solution in the optofluidic CD platform. After 30 cycles, the clear and high SERS signal of rhodamine 6G of 1 nM is readily detected. In addition to the preconcentration-based signal amplification by the optofluidic SERS system on the CD platform, we introduce a controlled precipitation of gold nanoparticles by CuSO 4 for SERS substrates. This method provides high-throughput, high-sensitive and large-area uniform SERS substrates on the optofluidic CD platform. The uniform SERS signals from different positions in spots of 3 mm 2 on the different CDs gives us confidence in the reliability and stability of our SERS substrates.

AB - In this paper, signal amplifications of surface-enhanced Raman scattering (SERS) are realized by an optofluidic compact disc (CD)-based preconcentration method for effective label-free environmental and biomolecular detections. The preconcentration of target molecules is accomplished through the accumulation of adsorbed molecules on SERS-active sites by repeating a 'filling-drying' cycle of the assay solution in the optofluidic CD platform. After 30 cycles, the clear and high SERS signal of rhodamine 6G of 1 nM is readily detected. In addition to the preconcentration-based signal amplification by the optofluidic SERS system on the CD platform, we introduce a controlled precipitation of gold nanoparticles by CuSO 4 for SERS substrates. This method provides high-throughput, high-sensitive and large-area uniform SERS substrates on the optofluidic CD platform. The uniform SERS signals from different positions in spots of 3 mm 2 on the different CDs gives us confidence in the reliability and stability of our SERS substrates.

UR - http://www.scopus.com/inward/record.url?scp=62749191526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=62749191526&partnerID=8YFLogxK

U2 - 10.1039/b812067f

DO - 10.1039/b812067f

M3 - Article

C2 - 19107279

AN - SCOPUS:62749191526

VL - 9

SP - 239

EP - 243

JO - Lab on a Chip - Miniaturisation for Chemistry and Biology

JF - Lab on a Chip - Miniaturisation for Chemistry and Biology

SN - 1473-0197

IS - 2

ER -