Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis

A birth cohort study (COCOA)

So Yeon Lee, Jinho Yu, Kang Mo Ahn, Kyung Won Kim, Youn Ho Shin, Kyung Shin Lee, Seo Ah Hong, Young Ho Jung, Eun Lee, Song I. Yang, Ju Hee Seo, Ji Won Kwon, Byoung Ju Kim, Hyo Bin Kim, Woo Kyung Kim, Dae-Jin Song, Gwang Cheon Jang, Jung Yeon Shim, Soo Young Lee, Ja Young Kwon & 8 others Suk Joo Choi, Kyung Ju Lee, Hee Jin Park, Hye Sung Won, Ho Sung Yoo, Mi Jin Kang, Hyung Young Kim, Soo Jong Hong

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. Methods: The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. Results: The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19-27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05). Conclusion: Cesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.

Original languageEnglish
Article numbere96603
JournalPLoS One
Volume9
Issue number5
DOIs
Publication statusPublished - 2014 May 21

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atopic dermatitis
Interleukin-13
cesarean section
Atopic Dermatitis
Polymorphism
cohort studies
additive effect
Cesarean Section
Cohort Studies
antibiotics
genetic polymorphism
Parturition
Anti-Bacterial Agents
Genotype
infancy
genotype
Microbiota
Pediatrics
Genetic Predisposition to Disease
interleukin-13

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis : A birth cohort study (COCOA). / Lee, So Yeon; Yu, Jinho; Ahn, Kang Mo; Kim, Kyung Won; Shin, Youn Ho; Lee, Kyung Shin; Hong, Seo Ah; Jung, Young Ho; Lee, Eun; Yang, Song I.; Seo, Ju Hee; Kwon, Ji Won; Kim, Byoung Ju; Kim, Hyo Bin; Kim, Woo Kyung; Song, Dae-Jin; Jang, Gwang Cheon; Shim, Jung Yeon; Lee, Soo Young; Kwon, Ja Young; Choi, Suk Joo; Lee, Kyung Ju; Park, Hee Jin; Won, Hye Sung; Yoo, Ho Sung; Kang, Mi Jin; Kim, Hyung Young; Hong, Soo Jong.

In: PLoS One, Vol. 9, No. 5, e96603, 21.05.2014.

Research output: Contribution to journalArticle

Lee, SY, Yu, J, Ahn, KM, Kim, KW, Shin, YH, Lee, KS, Hong, SA, Jung, YH, Lee, E, Yang, SI, Seo, JH, Kwon, JW, Kim, BJ, Kim, HB, Kim, WK, Song, D-J, Jang, GC, Shim, JY, Lee, SY, Kwon, JY, Choi, SJ, Lee, KJ, Park, HJ, Won, HS, Yoo, HS, Kang, MJ, Kim, HY & Hong, SJ 2014, 'Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis: A birth cohort study (COCOA)', PLoS One, vol. 9, no. 5, e96603. https://doi.org/10.1371/journal.pone.0096603
Lee, So Yeon ; Yu, Jinho ; Ahn, Kang Mo ; Kim, Kyung Won ; Shin, Youn Ho ; Lee, Kyung Shin ; Hong, Seo Ah ; Jung, Young Ho ; Lee, Eun ; Yang, Song I. ; Seo, Ju Hee ; Kwon, Ji Won ; Kim, Byoung Ju ; Kim, Hyo Bin ; Kim, Woo Kyung ; Song, Dae-Jin ; Jang, Gwang Cheon ; Shim, Jung Yeon ; Lee, Soo Young ; Kwon, Ja Young ; Choi, Suk Joo ; Lee, Kyung Ju ; Park, Hee Jin ; Won, Hye Sung ; Yoo, Ho Sung ; Kang, Mi Jin ; Kim, Hyung Young ; Hong, Soo Jong. / Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis : A birth cohort study (COCOA). In: PLoS One. 2014 ; Vol. 9, No. 5.
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abstract = "Background: Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. Methods: The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. Results: The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95{\%} CI, 1.19-27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05). Conclusion: Cesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.",
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T1 - Additive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis

T2 - A birth cohort study (COCOA)

AU - Lee, So Yeon

AU - Yu, Jinho

AU - Ahn, Kang Mo

AU - Kim, Kyung Won

AU - Shin, Youn Ho

AU - Lee, Kyung Shin

AU - Hong, Seo Ah

AU - Jung, Young Ho

AU - Lee, Eun

AU - Yang, Song I.

AU - Seo, Ju Hee

AU - Kwon, Ji Won

AU - Kim, Byoung Ju

AU - Kim, Hyo Bin

AU - Kim, Woo Kyung

AU - Song, Dae-Jin

AU - Jang, Gwang Cheon

AU - Shim, Jung Yeon

AU - Lee, Soo Young

AU - Kwon, Ja Young

AU - Choi, Suk Joo

AU - Lee, Kyung Ju

AU - Park, Hee Jin

AU - Won, Hye Sung

AU - Yoo, Ho Sung

AU - Kang, Mi Jin

AU - Kim, Hyung Young

AU - Hong, Soo Jong

PY - 2014/5/21

Y1 - 2014/5/21

N2 - Background: Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. Methods: The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. Results: The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19-27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05). Conclusion: Cesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.

AB - Background: Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. Methods: The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. Results: The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19-27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05). Conclusion: Cesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.

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