Adenosine generation and signaling during acute kidney injury

Jessica D. Bauerle, Almut Grenz, Jae Hwan Kim, H. Thomas Lee, Holger K. Eltzschig

    Research output: Contribution to journalShort surveypeer-review

    94 Citations (Scopus)

    Abstract

    Acute kidney injury (AKI) is among the leading causes of morbidity and mortality in hospitalized patients. Particularly in the perioperative period, the most common cause of AKI is renal ischemia. At present, therapeutic modalities to prevent or treat AKI are extremely limited and the search for novel therapeutic interventions for ischemic AKI is an area of intense investigation. Recent studies implicate the endogenous signaling molecule, adenosine, in kidney protection from ischemia. As such, enzymatic production of adenosine from its precursor molecules ATP and AMP, and signaling events through adenosine receptors, play a critical role in attenuating renal inflammation and preserving kidney function during episodes of renal ischemia. Utilizing genetic mouse models with defects in adenosine generation or signaling provide strong evidence for the key role of extracellular adenosine in adapting renal tissues to limited oxygen availability and attenuating hypoxiadriven inflammation of the kidneys. Moreover, experimental therapeutics targeting individual adenosine receptors demonstrate strong prophylactic or therapeutic effects during murine AKI. If these experimental strategies can be translated into a clinical setting, adenosine receptor therapeutics may become an integral part in the prevention or treatment of AKI from renal ischemia.

    Original languageEnglish
    Pages (from-to)14-20
    Number of pages7
    JournalJournal of the American Society of Nephrology
    Volume22
    Issue number1
    DOIs
    Publication statusPublished - 2011 Jan

    ASJC Scopus subject areas

    • Nephrology

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