Adherence to guidelines for antithrombotic therapy in patients with atrial fibrillation according to CHADS2 score before and after stroke: A multicenter observational study from Korea

Wook Joo Kim, Jong Moo Park, Kyusik Kang, Yong Jin Cho, Keun Sik Hong, Soo Joo Lee, Youngchai Ko, Kyung Bok Lee, Tai Hwan Park, Jun Lee, Jae Kwan Cha, Dae Hyun Kim, Kyung Ho Yu, Byung Chul Lee, Mi Sun Oh, Juneyoung Lee, Jisung Lee, Myung Suk Jang, Moon Ku Han, Hee Joon Bae

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9 Citations (Scopus)

Abstract

Background and PurposezzA substantial proportion of patients with atrial fibrillation (AF) are not treated optimally; however, the inappropriateness of drug therapy has never been evaluated before or after a stroke event. We investigated the adherence to guidelines for ther- apy in AF patients hospitalized with acute ischemic stroke (AIS) before stroke onset and at discharge, with the aim of identifying the factors associated with inappropriate therapy. MethodszzAIS patients with AF hospitalized within 7 days of onset were identified from a prospective nine-center stroke registry database. Two cohorts were defined: patients diag- nosed with AF prior to the stroke event (admission cohort) and patients diagnosed with AF at discharge from hospital (discharge cohort). Any of the following conditions were regarded as nonadherence to guidelines in this study: use of anticoagulant or nonuse of antithrombot- ics with CHADS2 score=0, nonuse of antithrombotics with CHADS2 score=1, or nonuse of anticoagulant with CHADS2 score ≥2. ResultszzOverall, 406 patients were enrolled in the admission cohort and 518 in the dis- charge cohort. The rates of nonadherence before a stroke event and at discharge were 77.8% and 33.3%, respectively. These rates varied widely for both cohorts, with interhospital differ- ences being statistically significant. Multivariable analysis revealed that old age, stroke histo- ry, and congestive heart failure were associated with nonadherence before stroke. At dis- charge, males, coronary heart disease, inappropriate antithrombotic use before stroke, and functional disability at discharge were associated with nonadherence. ConclusionszzThis study shows that antithrombotic use in AIS patients with AF might be not optimal before and after stroke in Korea.

Original languageEnglish
Pages (from-to)34-41
Number of pages8
JournalJournal of Clinical Neurology (Korea)
Volume12
Issue number1
DOIs
Publication statusPublished - 2016 Jan

Keywords

  • Atrial fibrillation
  • Cerebral infarction
  • Drug utilization review
  • Guideline adherence

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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