Adherence with electronic monitoring and symptoms in children with attention deficit hyperactivity disorder

Jaewon Yang, Byung Moon Yoon, Moon-Soo Lee, Sook Haeng Joe, In Kwa Jung, Seung Hyun Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective The primary aim of this study was to compare electronic monitoring with other measures of adherence to Osmotic-controlled Release Oral delivery System methylphenidate in children with attention-deficit hyperactivity disorder (ADHD). The secondary aim was to analyze the relationships between adherence and clinical factors, including ADHD symptoms. Methods Thirty-nine children diagnosed with ADHD were monitored for adherence to medication over the course of eight weeks. Medication adherence was assessed using the Medication Event Monitoring System (MEMS), which is a bottle cap with a microprocessor that records all instances and times that the bottle is opened; patient self-report; clinician rating; and pill count. Information, including demographic and clinical characteristics, symptom rating scale, and psychological test results, were also collected. The relationships between adherence and clinical factors, including ADHD rating scores of baseline and of the changes, were assessed. Results The rate of non-adherence measured by the MEMS was found to be 46.2%, which was considerably higher than those of the patient self-report (17.9%), clinician rating (31.7%), and pill count (12.8%) of non-adherence. The rate of adherence measured by the MEMS was not significantly associated with baseline symptom severity or symptom changes over the eight weeks, although non-adherent group showed more severe baseline symptoms and inferior improvement. Conclusion Adherence as measured by the MEMS showed a discrepancy with other measures of adherence in patients with ADHD. The symptom severity and level of improvement were not related to adherence with MEMS. Further studies are needed to evaluate the variables that may impact medication adherence in children with ADHD.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalPsychiatry Investigation
Volume9
Issue number3
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Medication Adherence
Attention Deficit Disorder with Hyperactivity
Self Report
Psychological Tests
Methylphenidate
Microcomputers
Patient Compliance
Demography

Keywords

  • Adherence
  • Attention-deficit hyperactivity disorder
  • Medication event monitoring system
  • Symptoms

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Adherence with electronic monitoring and symptoms in children with attention deficit hyperactivity disorder. / Yang, Jaewon; Yoon, Byung Moon; Lee, Moon-Soo; Joe, Sook Haeng; Jung, In Kwa; Kim, Seung Hyun.

In: Psychiatry Investigation, Vol. 9, No. 3, 01.10.2012, p. 263-268.

Research output: Contribution to journalArticle

Yang, Jaewon ; Yoon, Byung Moon ; Lee, Moon-Soo ; Joe, Sook Haeng ; Jung, In Kwa ; Kim, Seung Hyun. / Adherence with electronic monitoring and symptoms in children with attention deficit hyperactivity disorder. In: Psychiatry Investigation. 2012 ; Vol. 9, No. 3. pp. 263-268.
@article{51e47c9218b34c0ea3c4efc1fb4e168f,
title = "Adherence with electronic monitoring and symptoms in children with attention deficit hyperactivity disorder",
abstract = "Objective The primary aim of this study was to compare electronic monitoring with other measures of adherence to Osmotic-controlled Release Oral delivery System methylphenidate in children with attention-deficit hyperactivity disorder (ADHD). The secondary aim was to analyze the relationships between adherence and clinical factors, including ADHD symptoms. Methods Thirty-nine children diagnosed with ADHD were monitored for adherence to medication over the course of eight weeks. Medication adherence was assessed using the Medication Event Monitoring System (MEMS), which is a bottle cap with a microprocessor that records all instances and times that the bottle is opened; patient self-report; clinician rating; and pill count. Information, including demographic and clinical characteristics, symptom rating scale, and psychological test results, were also collected. The relationships between adherence and clinical factors, including ADHD rating scores of baseline and of the changes, were assessed. Results The rate of non-adherence measured by the MEMS was found to be 46.2{\%}, which was considerably higher than those of the patient self-report (17.9{\%}), clinician rating (31.7{\%}), and pill count (12.8{\%}) of non-adherence. The rate of adherence measured by the MEMS was not significantly associated with baseline symptom severity or symptom changes over the eight weeks, although non-adherent group showed more severe baseline symptoms and inferior improvement. Conclusion Adherence as measured by the MEMS showed a discrepancy with other measures of adherence in patients with ADHD. The symptom severity and level of improvement were not related to adherence with MEMS. Further studies are needed to evaluate the variables that may impact medication adherence in children with ADHD.",
keywords = "Adherence, Attention-deficit hyperactivity disorder, Medication event monitoring system, Symptoms",
author = "Jaewon Yang and Yoon, {Byung Moon} and Moon-Soo Lee and Joe, {Sook Haeng} and Jung, {In Kwa} and Kim, {Seung Hyun}",
year = "2012",
month = "10",
day = "1",
doi = "10.4306/pi.2012.9.3.263",
language = "English",
volume = "9",
pages = "263--268",
journal = "Psychiatry Investigation",
issn = "1738-3684",
publisher = "Korean Neuropsychiatric Association",
number = "3",

}

TY - JOUR

T1 - Adherence with electronic monitoring and symptoms in children with attention deficit hyperactivity disorder

AU - Yang, Jaewon

AU - Yoon, Byung Moon

AU - Lee, Moon-Soo

AU - Joe, Sook Haeng

AU - Jung, In Kwa

AU - Kim, Seung Hyun

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Objective The primary aim of this study was to compare electronic monitoring with other measures of adherence to Osmotic-controlled Release Oral delivery System methylphenidate in children with attention-deficit hyperactivity disorder (ADHD). The secondary aim was to analyze the relationships between adherence and clinical factors, including ADHD symptoms. Methods Thirty-nine children diagnosed with ADHD were monitored for adherence to medication over the course of eight weeks. Medication adherence was assessed using the Medication Event Monitoring System (MEMS), which is a bottle cap with a microprocessor that records all instances and times that the bottle is opened; patient self-report; clinician rating; and pill count. Information, including demographic and clinical characteristics, symptom rating scale, and psychological test results, were also collected. The relationships between adherence and clinical factors, including ADHD rating scores of baseline and of the changes, were assessed. Results The rate of non-adherence measured by the MEMS was found to be 46.2%, which was considerably higher than those of the patient self-report (17.9%), clinician rating (31.7%), and pill count (12.8%) of non-adherence. The rate of adherence measured by the MEMS was not significantly associated with baseline symptom severity or symptom changes over the eight weeks, although non-adherent group showed more severe baseline symptoms and inferior improvement. Conclusion Adherence as measured by the MEMS showed a discrepancy with other measures of adherence in patients with ADHD. The symptom severity and level of improvement were not related to adherence with MEMS. Further studies are needed to evaluate the variables that may impact medication adherence in children with ADHD.

AB - Objective The primary aim of this study was to compare electronic monitoring with other measures of adherence to Osmotic-controlled Release Oral delivery System methylphenidate in children with attention-deficit hyperactivity disorder (ADHD). The secondary aim was to analyze the relationships between adherence and clinical factors, including ADHD symptoms. Methods Thirty-nine children diagnosed with ADHD were monitored for adherence to medication over the course of eight weeks. Medication adherence was assessed using the Medication Event Monitoring System (MEMS), which is a bottle cap with a microprocessor that records all instances and times that the bottle is opened; patient self-report; clinician rating; and pill count. Information, including demographic and clinical characteristics, symptom rating scale, and psychological test results, were also collected. The relationships between adherence and clinical factors, including ADHD rating scores of baseline and of the changes, were assessed. Results The rate of non-adherence measured by the MEMS was found to be 46.2%, which was considerably higher than those of the patient self-report (17.9%), clinician rating (31.7%), and pill count (12.8%) of non-adherence. The rate of adherence measured by the MEMS was not significantly associated with baseline symptom severity or symptom changes over the eight weeks, although non-adherent group showed more severe baseline symptoms and inferior improvement. Conclusion Adherence as measured by the MEMS showed a discrepancy with other measures of adherence in patients with ADHD. The symptom severity and level of improvement were not related to adherence with MEMS. Further studies are needed to evaluate the variables that may impact medication adherence in children with ADHD.

KW - Adherence

KW - Attention-deficit hyperactivity disorder

KW - Medication event monitoring system

KW - Symptoms

UR - http://www.scopus.com/inward/record.url?scp=84866714914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866714914&partnerID=8YFLogxK

U2 - 10.4306/pi.2012.9.3.263

DO - 10.4306/pi.2012.9.3.263

M3 - Article

VL - 9

SP - 263

EP - 268

JO - Psychiatry Investigation

JF - Psychiatry Investigation

SN - 1738-3684

IS - 3

ER -