Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell

Hyun Kang Jee, Young Lee Yoon, Yeon Yu Byung, Beom Seok Yang, Kyung Hwan Cho, Kyoung Yoon Do, Kyun Roh Yong

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Recently, it was reported that reduction in serum adiponectin levels is correlated with the incidence of breast cancer. As an effort to explain this, we screened various human breast cancer cell lines to identify those in which proliferation is directly controlled by adiponectin. Among the five tested cell lines, proliferation of MDA-MB-231 cancer cell was significantly suppressed by adiponectin within the range of physiological concentration. Furthermore, prolonged adiponectin treatment caused cell growth arrest and even apoptosis of MDA-MB-231. This result is the first to show that adiponectin can directly control cancer cell growth and provides a rationale for the theory that reduction in plasma adiponectin levels could be a risk factor for breast cancer.

Original languageEnglish
Pages (from-to)1263-1269
Number of pages7
JournalArchives of pharmacal research
Volume28
Issue number11
DOIs
Publication statusPublished - 2005 Nov

Keywords

  • Adiponectin
  • Apoptosis
  • Breast cancer
  • Growth arrest
  • MDA-MB-231

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Jee, H. K., Yoon, Y. L., Byung, Y. Y., Yang, B. S., Cho, K. H., Do, K. Y., & Yong, K. R. (2005). Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell. Archives of pharmacal research, 28(11), 1263-1269. https://doi.org/10.1007/bf02978210