Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men

Samar R. El Khoudary, Emma Barinas-Mitchell, Jessica White, Kim Sutton-Tyrrell, Lewis H. Kuller, J. David Curb, Chol Shin, Hirotsugu Ueshima, Kamal Masaki, Rhobert W. Evans, Katsuyuki Miura, Daniel Edmundowicz, Akira Sekikawa

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: Limited data are available about risk factors for the progression of aortic stiffness in healthy population. We examined several risk factors as possible independent predictors of aortic stiffness progression among a population-based sample of US men. Methods: A total of 240 men (40-49 years) free of CVD at baseline from the Pittsburgh site of the ERA JUMP study were evaluated. Aortic stiffness was measured as carotid-femoral pulse wave velocity at baseline and after 4.6 ± 0.2 (mean ± SD) years of follow-up. Progression of aortic stiffness was evaluated as relative annual change in carotid-femoral pulse wave velocity (% change/year). Using linear regression, both baseline potential risk factors and their annual changes were evaluated as possible risk factors for aortic stiffness progression. Baseline age, follow-up time, race, heart rate, and medications use were forced in all models. Results: During follow-up, relative to baseline level, aortic stiffness increased 0.3% ± 5.3% per year. In final models, the independent predictors of degree of aortic stiffness progression were lower levels of adiponectin (P = 0.03), higher levels of systolic blood pressure (P = 0.03), greater annual change in systolic blood pressure (P = 0.04), and alcohol consumption ≥ 2 times/week (P = 0.02). Adiponectin levels within the third (9.8 μg/Ml ≤ adiponectin < 13.0 μg/mL) and the fourth (adiponectin ≥ 13.0 μg/mL) quartiles were associated with an improvement in relative annual aortic stiffness progression (P = 0.02, P = 0.01, respectively) compared to levels within the first quartile (adiponectin ≤ 7.0 μg/mL). Conclusion: Among apparently healthy men, lower levels of baseline adiponectin could be a novel marker for greater risk of aortic stiffness progression. Longitudinal research is required to evaluate whether adiponectin change over time would have similar association with aortic stiffness progression.

Original languageEnglish
Pages (from-to)475-480
Number of pages6
JournalAtherosclerosis
Volume225
Issue number2
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Vascular Stiffness
Adiponectin
Alcohol Drinking
Blood Pressure
Pulse Wave Analysis
Thigh
Population
Linear Models
Heart Rate

Keywords

  • Arteriosclerosis
  • Hypertension
  • Pulse wave velocity
  • Risk factors
  • Stiffness

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

El Khoudary, S. R., Barinas-Mitchell, E., White, J., Sutton-Tyrrell, K., Kuller, L. H., Curb, J. D., ... Sekikawa, A. (2012). Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men. Atherosclerosis, 225(2), 475-480. https://doi.org/10.1016/j.atherosclerosis.2012.09.015

Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men. / El Khoudary, Samar R.; Barinas-Mitchell, Emma; White, Jessica; Sutton-Tyrrell, Kim; Kuller, Lewis H.; Curb, J. David; Shin, Chol; Ueshima, Hirotsugu; Masaki, Kamal; Evans, Rhobert W.; Miura, Katsuyuki; Edmundowicz, Daniel; Sekikawa, Akira.

In: Atherosclerosis, Vol. 225, No. 2, 01.12.2012, p. 475-480.

Research output: Contribution to journalArticle

El Khoudary, SR, Barinas-Mitchell, E, White, J, Sutton-Tyrrell, K, Kuller, LH, Curb, JD, Shin, C, Ueshima, H, Masaki, K, Evans, RW, Miura, K, Edmundowicz, D & Sekikawa, A 2012, 'Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men', Atherosclerosis, vol. 225, no. 2, pp. 475-480. https://doi.org/10.1016/j.atherosclerosis.2012.09.015
El Khoudary, Samar R. ; Barinas-Mitchell, Emma ; White, Jessica ; Sutton-Tyrrell, Kim ; Kuller, Lewis H. ; Curb, J. David ; Shin, Chol ; Ueshima, Hirotsugu ; Masaki, Kamal ; Evans, Rhobert W. ; Miura, Katsuyuki ; Edmundowicz, Daniel ; Sekikawa, Akira. / Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men. In: Atherosclerosis. 2012 ; Vol. 225, No. 2. pp. 475-480.
@article{9c70b6bd7dec40feb08eb0aaf8c82ff7,
title = "Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men",
abstract = "Objective: Limited data are available about risk factors for the progression of aortic stiffness in healthy population. We examined several risk factors as possible independent predictors of aortic stiffness progression among a population-based sample of US men. Methods: A total of 240 men (40-49 years) free of CVD at baseline from the Pittsburgh site of the ERA JUMP study were evaluated. Aortic stiffness was measured as carotid-femoral pulse wave velocity at baseline and after 4.6 ± 0.2 (mean ± SD) years of follow-up. Progression of aortic stiffness was evaluated as relative annual change in carotid-femoral pulse wave velocity ({\%} change/year). Using linear regression, both baseline potential risk factors and their annual changes were evaluated as possible risk factors for aortic stiffness progression. Baseline age, follow-up time, race, heart rate, and medications use were forced in all models. Results: During follow-up, relative to baseline level, aortic stiffness increased 0.3{\%} ± 5.3{\%} per year. In final models, the independent predictors of degree of aortic stiffness progression were lower levels of adiponectin (P = 0.03), higher levels of systolic blood pressure (P = 0.03), greater annual change in systolic blood pressure (P = 0.04), and alcohol consumption ≥ 2 times/week (P = 0.02). Adiponectin levels within the third (9.8 μg/Ml ≤ adiponectin < 13.0 μg/mL) and the fourth (adiponectin ≥ 13.0 μg/mL) quartiles were associated with an improvement in relative annual aortic stiffness progression (P = 0.02, P = 0.01, respectively) compared to levels within the first quartile (adiponectin ≤ 7.0 μg/mL). Conclusion: Among apparently healthy men, lower levels of baseline adiponectin could be a novel marker for greater risk of aortic stiffness progression. Longitudinal research is required to evaluate whether adiponectin change over time would have similar association with aortic stiffness progression.",
keywords = "Arteriosclerosis, Hypertension, Pulse wave velocity, Risk factors, Stiffness",
author = "{El Khoudary}, {Samar R.} and Emma Barinas-Mitchell and Jessica White and Kim Sutton-Tyrrell and Kuller, {Lewis H.} and Curb, {J. David} and Chol Shin and Hirotsugu Ueshima and Kamal Masaki and Evans, {Rhobert W.} and Katsuyuki Miura and Daniel Edmundowicz and Akira Sekikawa",
year = "2012",
month = "12",
day = "1",
doi = "10.1016/j.atherosclerosis.2012.09.015",
language = "English",
volume = "225",
pages = "475--480",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Adiponectin, systolic blood pressure, and alcohol consumption are associated with more aortic stiffness progression among apparently healthy men

AU - El Khoudary, Samar R.

AU - Barinas-Mitchell, Emma

AU - White, Jessica

AU - Sutton-Tyrrell, Kim

AU - Kuller, Lewis H.

AU - Curb, J. David

AU - Shin, Chol

AU - Ueshima, Hirotsugu

AU - Masaki, Kamal

AU - Evans, Rhobert W.

AU - Miura, Katsuyuki

AU - Edmundowicz, Daniel

AU - Sekikawa, Akira

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Objective: Limited data are available about risk factors for the progression of aortic stiffness in healthy population. We examined several risk factors as possible independent predictors of aortic stiffness progression among a population-based sample of US men. Methods: A total of 240 men (40-49 years) free of CVD at baseline from the Pittsburgh site of the ERA JUMP study were evaluated. Aortic stiffness was measured as carotid-femoral pulse wave velocity at baseline and after 4.6 ± 0.2 (mean ± SD) years of follow-up. Progression of aortic stiffness was evaluated as relative annual change in carotid-femoral pulse wave velocity (% change/year). Using linear regression, both baseline potential risk factors and their annual changes were evaluated as possible risk factors for aortic stiffness progression. Baseline age, follow-up time, race, heart rate, and medications use were forced in all models. Results: During follow-up, relative to baseline level, aortic stiffness increased 0.3% ± 5.3% per year. In final models, the independent predictors of degree of aortic stiffness progression were lower levels of adiponectin (P = 0.03), higher levels of systolic blood pressure (P = 0.03), greater annual change in systolic blood pressure (P = 0.04), and alcohol consumption ≥ 2 times/week (P = 0.02). Adiponectin levels within the third (9.8 μg/Ml ≤ adiponectin < 13.0 μg/mL) and the fourth (adiponectin ≥ 13.0 μg/mL) quartiles were associated with an improvement in relative annual aortic stiffness progression (P = 0.02, P = 0.01, respectively) compared to levels within the first quartile (adiponectin ≤ 7.0 μg/mL). Conclusion: Among apparently healthy men, lower levels of baseline adiponectin could be a novel marker for greater risk of aortic stiffness progression. Longitudinal research is required to evaluate whether adiponectin change over time would have similar association with aortic stiffness progression.

AB - Objective: Limited data are available about risk factors for the progression of aortic stiffness in healthy population. We examined several risk factors as possible independent predictors of aortic stiffness progression among a population-based sample of US men. Methods: A total of 240 men (40-49 years) free of CVD at baseline from the Pittsburgh site of the ERA JUMP study were evaluated. Aortic stiffness was measured as carotid-femoral pulse wave velocity at baseline and after 4.6 ± 0.2 (mean ± SD) years of follow-up. Progression of aortic stiffness was evaluated as relative annual change in carotid-femoral pulse wave velocity (% change/year). Using linear regression, both baseline potential risk factors and their annual changes were evaluated as possible risk factors for aortic stiffness progression. Baseline age, follow-up time, race, heart rate, and medications use were forced in all models. Results: During follow-up, relative to baseline level, aortic stiffness increased 0.3% ± 5.3% per year. In final models, the independent predictors of degree of aortic stiffness progression were lower levels of adiponectin (P = 0.03), higher levels of systolic blood pressure (P = 0.03), greater annual change in systolic blood pressure (P = 0.04), and alcohol consumption ≥ 2 times/week (P = 0.02). Adiponectin levels within the third (9.8 μg/Ml ≤ adiponectin < 13.0 μg/mL) and the fourth (adiponectin ≥ 13.0 μg/mL) quartiles were associated with an improvement in relative annual aortic stiffness progression (P = 0.02, P = 0.01, respectively) compared to levels within the first quartile (adiponectin ≤ 7.0 μg/mL). Conclusion: Among apparently healthy men, lower levels of baseline adiponectin could be a novel marker for greater risk of aortic stiffness progression. Longitudinal research is required to evaluate whether adiponectin change over time would have similar association with aortic stiffness progression.

KW - Arteriosclerosis

KW - Hypertension

KW - Pulse wave velocity

KW - Risk factors

KW - Stiffness

UR - http://www.scopus.com/inward/record.url?scp=84869502868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869502868&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2012.09.015

DO - 10.1016/j.atherosclerosis.2012.09.015

M3 - Article

C2 - 23040831

AN - SCOPUS:84869502868

VL - 225

SP - 475

EP - 480

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -