Adipose tissue-derived stem cells for myocardial regeneration

Hyung Joon Joo; Jong Ho Kim; Soon Jun Hong

doi:10.4070/kcj.2016.0207

Adipose tissue-derived stem cells for myocardial regeneration

Hyung Joon Joo, Jong Ho Kim, Soon Jun Hong

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

Over the past decade, stem cell therapy has been extensively studied for clinical application for heart diseases. Among various stem cells, adipose tissue-derived stem cell (ADSC) is still an attractive stem cell resource due to its abundance and easy accessibility. In vitro studies showed the multipotent differentiation potentials of ADSC, even differentiation into cardiomyocytes. Many pre-clinical animal studies have also demonstrated promising therapeutic results of ADSC. Furthermore, there were several clinical trials showing the positive results in acute myocardial infarction using ADSC. The present article covers the brief introduction, the suggested therapeutic mechanisms, application methods including cell dose and delivery, and human clinical trials of ADSC for myocardial regeneration.

Original language	English
Pages (from-to)	151-159
Number of pages	9
Journal	Korean Circulation Journal
Volume	47
Issue number	2
DOIs	https://doi.org/10.4070/kcj.2016.0207
Publication status	Published - 2017 Mar
Externally published	Yes

Keywords

Adipose tissue
Myocardium
Regeneration
Stem cell

ASJC Scopus subject areas

Internal Medicine
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4070/kcj.2016.0207

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title = "Adipose tissue-derived stem cells for myocardial regeneration",

abstract = "Over the past decade, stem cell therapy has been extensively studied for clinical application for heart diseases. Among various stem cells, adipose tissue-derived stem cell (ADSC) is still an attractive stem cell resource due to its abundance and easy accessibility. In vitro studies showed the multipotent differentiation potentials of ADSC, even differentiation into cardiomyocytes. Many pre-clinical animal studies have also demonstrated promising therapeutic results of ADSC. Furthermore, there were several clinical trials showing the positive results in acute myocardial infarction using ADSC. The present article covers the brief introduction, the suggested therapeutic mechanisms, application methods including cell dose and delivery, and human clinical trials of ADSC for myocardial regeneration.",

keywords = "Adipose tissue, Myocardium, Regeneration, Stem cell",

author = "Joo, {Hyung Joon} and Kim, {Jong Ho} and Hong, {Soon Jun}",

note = "Funding Information: This research was supported by a grant of the Korea Health Technology RandD Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare (Grant number: HI14C0209), and by a grant of the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (No. NRF-2014R1A2A1A11051998), Republic of Korea. Publisher Copyright: Copyright {\textcopyright} 2017 The Korean Society of Cardiology.",

year = "2017",

month = mar,

doi = "10.4070/kcj.2016.0207",

language = "English",

volume = "47",

pages = "151--159",

journal = "Korean Circulation Journal",

issn = "1738-5520",

publisher = "Korean Society of Circulation",

number = "2",

}

TY - JOUR

T1 - Adipose tissue-derived stem cells for myocardial regeneration

AU - Joo, Hyung Joon

AU - Kim, Jong Ho

AU - Hong, Soon Jun

N1 - Funding Information: This research was supported by a grant of the Korea Health Technology RandD Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare (Grant number: HI14C0209), and by a grant of the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (No. NRF-2014R1A2A1A11051998), Republic of Korea. Publisher Copyright: Copyright © 2017 The Korean Society of Cardiology.

PY - 2017/3

Y1 - 2017/3

N2 - Over the past decade, stem cell therapy has been extensively studied for clinical application for heart diseases. Among various stem cells, adipose tissue-derived stem cell (ADSC) is still an attractive stem cell resource due to its abundance and easy accessibility. In vitro studies showed the multipotent differentiation potentials of ADSC, even differentiation into cardiomyocytes. Many pre-clinical animal studies have also demonstrated promising therapeutic results of ADSC. Furthermore, there were several clinical trials showing the positive results in acute myocardial infarction using ADSC. The present article covers the brief introduction, the suggested therapeutic mechanisms, application methods including cell dose and delivery, and human clinical trials of ADSC for myocardial regeneration.

AB - Over the past decade, stem cell therapy has been extensively studied for clinical application for heart diseases. Among various stem cells, adipose tissue-derived stem cell (ADSC) is still an attractive stem cell resource due to its abundance and easy accessibility. In vitro studies showed the multipotent differentiation potentials of ADSC, even differentiation into cardiomyocytes. Many pre-clinical animal studies have also demonstrated promising therapeutic results of ADSC. Furthermore, there were several clinical trials showing the positive results in acute myocardial infarction using ADSC. The present article covers the brief introduction, the suggested therapeutic mechanisms, application methods including cell dose and delivery, and human clinical trials of ADSC for myocardial regeneration.

KW - Adipose tissue

KW - Myocardium

KW - Regeneration

KW - Stem cell

UR - http://www.scopus.com/inward/record.url?scp=85017405118&partnerID=8YFLogxK

U2 - 10.4070/kcj.2016.0207

DO - 10.4070/kcj.2016.0207

M3 - Review article

AN - SCOPUS:85017405118

VL - 47

SP - 151

EP - 159

JO - Korean Circulation Journal

JF - Korean Circulation Journal

SN - 1738-5520

IS - 2

ER -

Adipose tissue-derived stem cells for myocardial regeneration

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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