Adolescent pregnancy is associated with osteoporosis in postmenopausal women

Geum Joon Cho, Jung Ho Shin, Kyong Wook Yi, Hyun Tae Park, Tak Kim, Jun Young Hur, Sun Haeng Kim

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)

    Abstract

    Objective: Adolescence is a critical time of life to accumulate bone for peak bone mass. Factors that may interfere with bone mass accrual during this period may increase the risk of osteoporosis. Several studies have reported that pregnancy during adolescence has detrimental effects on bone mass measurements after pregnancy. However, less is known about how adolescent pregnancy affects bone mineral density (BMD) and osteoporosis after menopause. The aim of this study was to evaluate the association between adolescent pregnancy and osteoporosis in postmenopausal Korean women. Methods: We conducted a cross-sectional study of 719 postmenopausal women, all of whom were enrolled in the Korean National Health and Nutrition Examination Survey in 2008. BMD was measured using dual-energy X-ray absorptiometry. Results: Postmenopausal women with histories of adolescent pregnancy had lower BMD of the total hip, femoral neck, and lumbar spine than did women without histories of adolescent pregnancy. Multivariate logistic regression analyses revealed that postmenopausal women with history of adolescent pregnancy were at increased risk of osteoporosis (odds ratio, 2.20; 95% CI, 1.12-4.30) compared with women without history of adolescent pregnancy after adjustments for age, body mass index, marital status, education level, household income, alcohol intake, smoking history, exercise, age at menarche, age at menopause, parity, hormone therapy use, intake of energy and calcium, and vitamin D level. Conclusions: Adolescent pregnancy may be a predictor of osteoporosis in postmenopausal women.

    Original languageEnglish
    Pages (from-to)456-460
    Number of pages5
    JournalMenopause
    Volume19
    Issue number4
    DOIs
    Publication statusPublished - 2012 Apr

    Keywords

    • Adolescence
    • Bone mineral density
    • Osteoporosis
    • Pregnancy

    ASJC Scopus subject areas

    • Obstetrics and Gynaecology

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