Adolescent pregnancy is associated with osteoporosis in postmenopausal women

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: Adolescence is a critical time of life to accumulate bone for peak bone mass. Factors that may interfere with bone mass accrual during this period may increase the risk of osteoporosis. Several studies have reported that pregnancy during adolescence has detrimental effects on bone mass measurements after pregnancy. However, less is known about how adolescent pregnancy affects bone mineral density (BMD) and osteoporosis after menopause. The aim of this study was to evaluate the association between adolescent pregnancy and osteoporosis in postmenopausal Korean women. Methods: We conducted a cross-sectional study of 719 postmenopausal women, all of whom were enrolled in the Korean National Health and Nutrition Examination Survey in 2008. BMD was measured using dual-energy X-ray absorptiometry. Results: Postmenopausal women with histories of adolescent pregnancy had lower BMD of the total hip, femoral neck, and lumbar spine than did women without histories of adolescent pregnancy. Multivariate logistic regression analyses revealed that postmenopausal women with history of adolescent pregnancy were at increased risk of osteoporosis (odds ratio, 2.20; 95% CI, 1.12-4.30) compared with women without history of adolescent pregnancy after adjustments for age, body mass index, marital status, education level, household income, alcohol intake, smoking history, exercise, age at menarche, age at menopause, parity, hormone therapy use, intake of energy and calcium, and vitamin D level. Conclusions: Adolescent pregnancy may be a predictor of osteoporosis in postmenopausal women.

Original languageEnglish
Pages (from-to)456-460
Number of pages5
JournalMenopause
Volume19
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

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Pregnancy in Adolescence
Postmenopausal Osteoporosis
Bone Density
Osteoporosis
Menopause
Bone and Bones
Pregnancy
Menarche
Nutrition Surveys
Femur Neck
Photon Absorptiometry
Marital Status
Parity
Energy Intake
Vitamin D
Hip
Spine
Body Mass Index
Cross-Sectional Studies
Logistic Models

Keywords

  • Adolescence
  • Bone mineral density
  • Osteoporosis
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Adolescent pregnancy is associated with osteoporosis in postmenopausal women. / Cho, Geum-Joon; Shin, Jung-Ho; Yi, Kyong Wook; Park, Hyun-Tae; Kim, Tak; Hur, Jun Young; Kim, Sun Haeng.

In: Menopause, Vol. 19, No. 4, 01.04.2012, p. 456-460.

Research output: Contribution to journalArticle

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abstract = "Objective: Adolescence is a critical time of life to accumulate bone for peak bone mass. Factors that may interfere with bone mass accrual during this period may increase the risk of osteoporosis. Several studies have reported that pregnancy during adolescence has detrimental effects on bone mass measurements after pregnancy. However, less is known about how adolescent pregnancy affects bone mineral density (BMD) and osteoporosis after menopause. The aim of this study was to evaluate the association between adolescent pregnancy and osteoporosis in postmenopausal Korean women. Methods: We conducted a cross-sectional study of 719 postmenopausal women, all of whom were enrolled in the Korean National Health and Nutrition Examination Survey in 2008. BMD was measured using dual-energy X-ray absorptiometry. Results: Postmenopausal women with histories of adolescent pregnancy had lower BMD of the total hip, femoral neck, and lumbar spine than did women without histories of adolescent pregnancy. Multivariate logistic regression analyses revealed that postmenopausal women with history of adolescent pregnancy were at increased risk of osteoporosis (odds ratio, 2.20; 95{\%} CI, 1.12-4.30) compared with women without history of adolescent pregnancy after adjustments for age, body mass index, marital status, education level, household income, alcohol intake, smoking history, exercise, age at menarche, age at menopause, parity, hormone therapy use, intake of energy and calcium, and vitamin D level. Conclusions: Adolescent pregnancy may be a predictor of osteoporosis in postmenopausal women.",
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