Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice

Tae Soo Kim, Dong Hee Han, Yeon Ju Lee, Gi Hoon Son, Kyungjin Kim, Chang Ju Kim, Sehyung Cho

Research output: Contribution to journalArticlepeer-review

Abstract

We recently established an adrenal clock-disrupted transgenic mouse line (BMAS) that exhibits a dampened rhythm of corticosterone secretion and reduced amplitude of day/night activity. Here, we observe that voluntary wheel running increases the robustness and amplitude of both body temperature and home cage activity (HCA) rhythms in wild-type, but not in BMAS mice, but without affecting estrous cycle. Surprisingly, wheel running alters the HCA waveform of BMAS females in a way that preferentially increases the late nighttime (ZT21-ZT24) HCA. These results indicate that adrenal clock disruption causes the animals to respond differently to the voluntary exercise cue in middle-aged female mice.

Original languageEnglish
Pages (from-to)397-405
Number of pages9
JournalAnimal Cells and Systems
Volume17
Issue number6
DOIs
Publication statusPublished - 2013

Keywords

  • adrenal clock
  • biological rhythm
  • body temperature
  • exercise
  • home cage activity
  • middle-aged female mouse

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice'. Together they form a unique fingerprint.

Cite this