Adrenal peripheral oscillator in generating the circadian glucocorticoid rhythm

Sooyoung Chung, Gi Hoon Son, Kyungjin Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The mammalian circadian timing system is organized into hierarchical structures with a central clock in the suprachiasmatic nucleus (SCN) and subsidiary peripheral oscillators. After the discovery of the local clockwork in peripheral organs and tissues, which have a molecular makeup similar to the central pacemaker SCN, uncovering the roles of the peripheral clock in the rhythmic physiology has been an emerging goal in chronobiology. Glucocorticoid (GC) is a multifunctional adrenal steroid hormone that shows a robust circadian rhythm. The daily GC rhythm has long been thought to be governed by the SCN via the hypothalamus-pituitary-adrenal neuroendocrine axis. Recent findings, however, indicate that multiple regulatory mechanisms, including the adrenal intrinsic mechanism by the peripheral clock, are also involved. GC regulates diverse physiological processes and acts as a signal for resetting peripheral clocks, which suggests the importance of the GC rhythm in harmonizing overall circadian physiology and behavior. Therefore, in this review, we will discuss the important role of the adrenal peripheral clockwork in the circadian regulation of GC and its physiological relevance in the circadian timing system.

Original languageEnglish
Pages (from-to)71-81
Number of pages11
JournalAnnals of the New York Academy of Sciences
Volume1220
Issue number1
DOIs
Publication statusPublished - 2011 Mar 1
Externally publishedYes

Fingerprint

Circadian Rhythm
Glucocorticoids
Suprachiasmatic Nucleus
Clocks
Circadian Clocks
Physiology
Steroid hormones
Physiological Phenomena
Pacemakers
Hypothalamus
Steroids
Clock
Hormones
Tissue
Nucleus
Rhythm

Keywords

  • Adrenal peripheral clock
  • Biological clock
  • Circadian rhythm
  • Glucocorticoid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Adrenal peripheral oscillator in generating the circadian glucocorticoid rhythm. / Chung, Sooyoung; Son, Gi Hoon; Kim, Kyungjin.

In: Annals of the New York Academy of Sciences, Vol. 1220, No. 1, 01.03.2011, p. 71-81.

Research output: Contribution to journalArticle

@article{3cf88f61e01a4568b6b28d4d2b73f0ca,
title = "Adrenal peripheral oscillator in generating the circadian glucocorticoid rhythm",
abstract = "The mammalian circadian timing system is organized into hierarchical structures with a central clock in the suprachiasmatic nucleus (SCN) and subsidiary peripheral oscillators. After the discovery of the local clockwork in peripheral organs and tissues, which have a molecular makeup similar to the central pacemaker SCN, uncovering the roles of the peripheral clock in the rhythmic physiology has been an emerging goal in chronobiology. Glucocorticoid (GC) is a multifunctional adrenal steroid hormone that shows a robust circadian rhythm. The daily GC rhythm has long been thought to be governed by the SCN via the hypothalamus-pituitary-adrenal neuroendocrine axis. Recent findings, however, indicate that multiple regulatory mechanisms, including the adrenal intrinsic mechanism by the peripheral clock, are also involved. GC regulates diverse physiological processes and acts as a signal for resetting peripheral clocks, which suggests the importance of the GC rhythm in harmonizing overall circadian physiology and behavior. Therefore, in this review, we will discuss the important role of the adrenal peripheral clockwork in the circadian regulation of GC and its physiological relevance in the circadian timing system.",
keywords = "Adrenal peripheral clock, Biological clock, Circadian rhythm, Glucocorticoid",
author = "Sooyoung Chung and Son, {Gi Hoon} and Kyungjin Kim",
year = "2011",
month = "3",
day = "1",
doi = "10.1111/j.1749-6632.2010.05923.x",
language = "English",
volume = "1220",
pages = "71--81",
journal = "Annals of The Lyceum of Natural History of New York",
issn = "0890-6564",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Adrenal peripheral oscillator in generating the circadian glucocorticoid rhythm

AU - Chung, Sooyoung

AU - Son, Gi Hoon

AU - Kim, Kyungjin

PY - 2011/3/1

Y1 - 2011/3/1

N2 - The mammalian circadian timing system is organized into hierarchical structures with a central clock in the suprachiasmatic nucleus (SCN) and subsidiary peripheral oscillators. After the discovery of the local clockwork in peripheral organs and tissues, which have a molecular makeup similar to the central pacemaker SCN, uncovering the roles of the peripheral clock in the rhythmic physiology has been an emerging goal in chronobiology. Glucocorticoid (GC) is a multifunctional adrenal steroid hormone that shows a robust circadian rhythm. The daily GC rhythm has long been thought to be governed by the SCN via the hypothalamus-pituitary-adrenal neuroendocrine axis. Recent findings, however, indicate that multiple regulatory mechanisms, including the adrenal intrinsic mechanism by the peripheral clock, are also involved. GC regulates diverse physiological processes and acts as a signal for resetting peripheral clocks, which suggests the importance of the GC rhythm in harmonizing overall circadian physiology and behavior. Therefore, in this review, we will discuss the important role of the adrenal peripheral clockwork in the circadian regulation of GC and its physiological relevance in the circadian timing system.

AB - The mammalian circadian timing system is organized into hierarchical structures with a central clock in the suprachiasmatic nucleus (SCN) and subsidiary peripheral oscillators. After the discovery of the local clockwork in peripheral organs and tissues, which have a molecular makeup similar to the central pacemaker SCN, uncovering the roles of the peripheral clock in the rhythmic physiology has been an emerging goal in chronobiology. Glucocorticoid (GC) is a multifunctional adrenal steroid hormone that shows a robust circadian rhythm. The daily GC rhythm has long been thought to be governed by the SCN via the hypothalamus-pituitary-adrenal neuroendocrine axis. Recent findings, however, indicate that multiple regulatory mechanisms, including the adrenal intrinsic mechanism by the peripheral clock, are also involved. GC regulates diverse physiological processes and acts as a signal for resetting peripheral clocks, which suggests the importance of the GC rhythm in harmonizing overall circadian physiology and behavior. Therefore, in this review, we will discuss the important role of the adrenal peripheral clockwork in the circadian regulation of GC and its physiological relevance in the circadian timing system.

KW - Adrenal peripheral clock

KW - Biological clock

KW - Circadian rhythm

KW - Glucocorticoid

UR - http://www.scopus.com/inward/record.url?scp=79952480945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952480945&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2010.05923.x

DO - 10.1111/j.1749-6632.2010.05923.x

M3 - Article

C2 - 21388405

AN - SCOPUS:79952480945

VL - 1220

SP - 71

EP - 81

JO - Annals of The Lyceum of Natural History of New York

JF - Annals of The Lyceum of Natural History of New York

SN - 0890-6564

IS - 1

ER -