Advanced biotechnology-Assisted precise sonodynamic therapy

Yi Zhang, Xiangqian Zhang, Huocheng Yang, Le Yu, Yunjie Xu, Amit Sharma, Peng Yin, Xiangyang Li, Jong Seung Kim, Yao Sun

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)


Despite significant advances, the therapeutic impact of photodynamic therapy is still substantially hampered by the restricted penetration depth of light and the reactive oxygen species (ROS)-mediated toxicity, which is impeded by the shorter effective half-life and radius of ROS produced during treatment. Sonodynamic therapy (SDT), on the other hand, provides unrivalled benefits in deep-seated tumour ablation due to its deep penetration depth and not totally ROS-dependent toxicity, exhibiting enormous preclinical and clinical potential. In this tutorial review, we highlight imaging-guided precise SDT, which allows choosing the best treatment option and monitoring the therapy response in real-Time, as well as recent clinical trials based on SDT. Aside from that, the subtle design strategies of sonosensitizers based on tumour environment shaping and rational structure modification, as well as SDT combination treatment (chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, gas therapy and immunotherapy), aimed at a more effective treatment outcome, are summarized. Finally, we discussed the future of SDT for personalized cancer and other disease treatments. This journal is

Original languageEnglish
Pages (from-to)11227-11248
Number of pages22
JournalChemical Society Reviews
Issue number20
Publication statusPublished - 2021 Oct 21

ASJC Scopus subject areas

  • Chemistry(all)


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