Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly

Beom Joon Kim, Seung Hoon Lee, Chi Kyung Kim, Wi Sun Ryu, Hyung Min Kwon, Su Yeon Choi, Byung Woo Yoon

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Coronary artery calcification (CAC) scores are widely accepted to predict risk of coronary heart diseases and are associated with atherosclerosis in other vasculatures. Cerebral small vessel diseases (SVDs), including white matter lesions (WML), silent lacunar infarction (SLI) and cerebral microbleeds (CMB), are considered to develop in conjunction with pro-atherogenic conditions, measured by CAC scores. Methods and Results: Of 672 individuals aged ≥65 years that underwent health screening, 312 subjects with brain magnetic resonance imagings (MRIs) were enrolled in this study. The distribution of baseline characteristics among individuals with or without MRIs was not different. Clinical and laboratory information was collected and CAC scores were measured using multi-detector computed tomography. Cerebral SVD were independently assessed by 2 raters who were unaware of the CAC scores. The prevalence of CAC (CAC >0) was 71.7% in men and 50.0% in women. The associations between moderate-to-extensive CAC (CAC score ≥100) and WML (adjusted odds ratio and 95% confidence interval, 4.99 and 1.33-18.73), SLI (5.04 and 1.86-13.63) and CMB (6.07 and 1.54-23.94) remained significant after adjusting for relevant confounders. Conclusions: This study documents significant associations between CAC and cerebral SVDs. The findings suggest that SVDs in the brain and CAC in the heart may develop under similar systemic pathogenic processes.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalCirculation Journal
Volume75
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1
Externally publishedYes

Fingerprint

Cerebral Small Vessel Diseases
Coronary Vessels
Lacunar Stroke
Magnetic Resonance Imaging
Brain Diseases
Coronary Disease
Atherosclerosis

Keywords

  • Cerebral microbleeds
  • Cerebral small vessel disease
  • Coronary artery calcification
  • Silent lacunar infarction
  • White matter lesion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly. / Kim, Beom Joon; Lee, Seung Hoon; Kim, Chi Kyung; Ryu, Wi Sun; Kwon, Hyung Min; Choi, Su Yeon; Yoon, Byung Woo.

In: Circulation Journal, Vol. 75, No. 2, 01.02.2011, p. 451-456.

Research output: Contribution to journalArticle

Kim, Beom Joon ; Lee, Seung Hoon ; Kim, Chi Kyung ; Ryu, Wi Sun ; Kwon, Hyung Min ; Choi, Su Yeon ; Yoon, Byung Woo. / Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly. In: Circulation Journal. 2011 ; Vol. 75, No. 2. pp. 451-456.
@article{9e3ebf49b064439f94216c812079b8b4,
title = "Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly",
abstract = "Background: Coronary artery calcification (CAC) scores are widely accepted to predict risk of coronary heart diseases and are associated with atherosclerosis in other vasculatures. Cerebral small vessel diseases (SVDs), including white matter lesions (WML), silent lacunar infarction (SLI) and cerebral microbleeds (CMB), are considered to develop in conjunction with pro-atherogenic conditions, measured by CAC scores. Methods and Results: Of 672 individuals aged ≥65 years that underwent health screening, 312 subjects with brain magnetic resonance imagings (MRIs) were enrolled in this study. The distribution of baseline characteristics among individuals with or without MRIs was not different. Clinical and laboratory information was collected and CAC scores were measured using multi-detector computed tomography. Cerebral SVD were independently assessed by 2 raters who were unaware of the CAC scores. The prevalence of CAC (CAC >0) was 71.7{\%} in men and 50.0{\%} in women. The associations between moderate-to-extensive CAC (CAC score ≥100) and WML (adjusted odds ratio and 95{\%} confidence interval, 4.99 and 1.33-18.73), SLI (5.04 and 1.86-13.63) and CMB (6.07 and 1.54-23.94) remained significant after adjusting for relevant confounders. Conclusions: This study documents significant associations between CAC and cerebral SVDs. The findings suggest that SVDs in the brain and CAC in the heart may develop under similar systemic pathogenic processes.",
keywords = "Cerebral microbleeds, Cerebral small vessel disease, Coronary artery calcification, Silent lacunar infarction, White matter lesion",
author = "Kim, {Beom Joon} and Lee, {Seung Hoon} and Kim, {Chi Kyung} and Ryu, {Wi Sun} and Kwon, {Hyung Min} and Choi, {Su Yeon} and Yoon, {Byung Woo}",
year = "2011",
month = "2",
day = "1",
doi = "10.1253/circj.CJ-10-0762",
language = "English",
volume = "75",
pages = "451--456",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "2",

}

TY - JOUR

T1 - Advanced coronary artery calcification and cerebral small vessel diseases in the healthy elderly

AU - Kim, Beom Joon

AU - Lee, Seung Hoon

AU - Kim, Chi Kyung

AU - Ryu, Wi Sun

AU - Kwon, Hyung Min

AU - Choi, Su Yeon

AU - Yoon, Byung Woo

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background: Coronary artery calcification (CAC) scores are widely accepted to predict risk of coronary heart diseases and are associated with atherosclerosis in other vasculatures. Cerebral small vessel diseases (SVDs), including white matter lesions (WML), silent lacunar infarction (SLI) and cerebral microbleeds (CMB), are considered to develop in conjunction with pro-atherogenic conditions, measured by CAC scores. Methods and Results: Of 672 individuals aged ≥65 years that underwent health screening, 312 subjects with brain magnetic resonance imagings (MRIs) were enrolled in this study. The distribution of baseline characteristics among individuals with or without MRIs was not different. Clinical and laboratory information was collected and CAC scores were measured using multi-detector computed tomography. Cerebral SVD were independently assessed by 2 raters who were unaware of the CAC scores. The prevalence of CAC (CAC >0) was 71.7% in men and 50.0% in women. The associations between moderate-to-extensive CAC (CAC score ≥100) and WML (adjusted odds ratio and 95% confidence interval, 4.99 and 1.33-18.73), SLI (5.04 and 1.86-13.63) and CMB (6.07 and 1.54-23.94) remained significant after adjusting for relevant confounders. Conclusions: This study documents significant associations between CAC and cerebral SVDs. The findings suggest that SVDs in the brain and CAC in the heart may develop under similar systemic pathogenic processes.

AB - Background: Coronary artery calcification (CAC) scores are widely accepted to predict risk of coronary heart diseases and are associated with atherosclerosis in other vasculatures. Cerebral small vessel diseases (SVDs), including white matter lesions (WML), silent lacunar infarction (SLI) and cerebral microbleeds (CMB), are considered to develop in conjunction with pro-atherogenic conditions, measured by CAC scores. Methods and Results: Of 672 individuals aged ≥65 years that underwent health screening, 312 subjects with brain magnetic resonance imagings (MRIs) were enrolled in this study. The distribution of baseline characteristics among individuals with or without MRIs was not different. Clinical and laboratory information was collected and CAC scores were measured using multi-detector computed tomography. Cerebral SVD were independently assessed by 2 raters who were unaware of the CAC scores. The prevalence of CAC (CAC >0) was 71.7% in men and 50.0% in women. The associations between moderate-to-extensive CAC (CAC score ≥100) and WML (adjusted odds ratio and 95% confidence interval, 4.99 and 1.33-18.73), SLI (5.04 and 1.86-13.63) and CMB (6.07 and 1.54-23.94) remained significant after adjusting for relevant confounders. Conclusions: This study documents significant associations between CAC and cerebral SVDs. The findings suggest that SVDs in the brain and CAC in the heart may develop under similar systemic pathogenic processes.

KW - Cerebral microbleeds

KW - Cerebral small vessel disease

KW - Coronary artery calcification

KW - Silent lacunar infarction

KW - White matter lesion

UR - http://www.scopus.com/inward/record.url?scp=79251567382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251567382&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-10-0762

DO - 10.1253/circj.CJ-10-0762

M3 - Article

C2 - 21157110

AN - SCOPUS:79251567382

VL - 75

SP - 451

EP - 456

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 2

ER -