Advanced coronary artery calcification is associated with ischemic stroke

Beom Joon Kim, Su Yeon Choi, Seung Hoon Lee, Chi Kyung Kim, Wi Sun Ryu, Moon Ku Han, Byung Hee Oh, Hee Joon Bae, Byung Woo Yoon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Coronary artery calcification (CAC) is widely accepted as a quantitative index of subclinical atherosclerosis in the coronary artery, and is utilized as a valuable tool for the global risk assessment of cardiovascular events in individuals at intermediate risk. However, the association between CAC and ischemic stroke has not been evaluated. Methods: CAC scores were measured in 401 consecutive first-ever acute ischemic stroke patients and in 5,420 healthy subjects who underwent detailed medical health screening. The authors randomly matched case:referent sets (1:2) for gender, age, hypertension, diabetes and hyperlipidemia. Accordingly, 290 stroke cases were matched with 580 referent controls. Results: Moderate-to-extensive CAC (CAC ≥100) was detected in 78 (26.9%) of the ischemic stroke cases and in 120 (20.7%) of the referent controls. Conditional logistic regression analysis, which was conducted to investigate the association between categorized CAC scores and ischemic stroke, and adjusted for other relevant confounders, revealed that moderate-to-extensive CAC was associated with the occurrence of ischemic stroke (OR 1.72, 95% CI 1.05-2.80, compared to the subjects with no CAC). The mean ± SE of the AUC-ROC curve for Framingham risk score (FRS) plus CAC score (0.760 ± 0.018) was significantly greater than that of FRS alone (0.748 ± 0.018; p = 0.005). Conclusions: Our results demonstrate that moderate-to-extensive CAC is associated with an increased occurrence of ischemic stroke. In view of the contribution made by CAC to the risk assessment of cardiovascular diseases, the CAC score may be utilized to evaluate the risk of ischemic stroke.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalCerebrovascular Diseases
Volume30
Issue number1
DOIs
Publication statusPublished - 2010 Jun 1
Externally publishedYes

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Coronary Vessels
Stroke
Hyperlipidemias
ROC Curve
Area Under Curve
Atherosclerosis
Healthy Volunteers
Cardiovascular Diseases
Logistic Models
Regression Analysis
Hypertension
Health

Keywords

  • Coronary artery calcification
  • Coronary artery calcification score
  • Framingham risk score
  • Individualized risk assessment
  • Ischemic stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Kim, B. J., Choi, S. Y., Lee, S. H., Kim, C. K., Ryu, W. S., Han, M. K., ... Yoon, B. W. (2010). Advanced coronary artery calcification is associated with ischemic stroke. Cerebrovascular Diseases, 30(1), 93-100. https://doi.org/10.1159/000314711

Advanced coronary artery calcification is associated with ischemic stroke. / Kim, Beom Joon; Choi, Su Yeon; Lee, Seung Hoon; Kim, Chi Kyung; Ryu, Wi Sun; Han, Moon Ku; Oh, Byung Hee; Bae, Hee Joon; Yoon, Byung Woo.

In: Cerebrovascular Diseases, Vol. 30, No. 1, 01.06.2010, p. 93-100.

Research output: Contribution to journalArticle

Kim, BJ, Choi, SY, Lee, SH, Kim, CK, Ryu, WS, Han, MK, Oh, BH, Bae, HJ & Yoon, BW 2010, 'Advanced coronary artery calcification is associated with ischemic stroke', Cerebrovascular Diseases, vol. 30, no. 1, pp. 93-100. https://doi.org/10.1159/000314711
Kim, Beom Joon ; Choi, Su Yeon ; Lee, Seung Hoon ; Kim, Chi Kyung ; Ryu, Wi Sun ; Han, Moon Ku ; Oh, Byung Hee ; Bae, Hee Joon ; Yoon, Byung Woo. / Advanced coronary artery calcification is associated with ischemic stroke. In: Cerebrovascular Diseases. 2010 ; Vol. 30, No. 1. pp. 93-100.
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