Advanced glycation endproduct-induced diabetic complications

Hyun Sun Lee, Chung Oui Hong, Kwang Won Lee

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Diabetic complications are a leading cause of blindness, renal failure, and nerve damage. Additionally, diabetesaccelerated atherosclerosis leads to increased risk of myocardial infarction, stroke, and limb amputation. At the present time, 4 main molecular mechanisms have been implicated in hyperglyceamia-mediated vascular damage. In particular, advanced glycation endproducts (AGE), which are formed by complex, heterogeneous, sugar-derived protein modifications, have been implicated as a major pathogenic process for diabetic complications. Recently, AGE inhibitors such as aminoguanidin, ALT-946, and pyridoxamine have been reported. Such an integrating paradigm provides a new conceptual framework for future research on diabetes complications and on discovering drugs to prevent the progression of AGE-induced maladies.

Original languageEnglish
Pages (from-to)1131-1138
Number of pages8
JournalFood Science and Biotechnology
Volume17
Issue number6
Publication statusPublished - 2008

Keywords

  • Advanced glycation endproduct
  • Diabetes mellitus
  • Diabetic complication
  • Inhibitor
  • Reactive oxygen species (ros)

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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