Advanced glycation endproduct-induced diabetic complications

Hyun S. Lee, Chung O. Hong, Kwang Won Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Diabetic complications are a leading cause of blindness, renal failure, and nerve damage. Additionally, diabetesaccelerated atherosclerosis leads to increased risk of myocardial infarction, stroke, and limb amputation. At the present time, 4 main molecular mechanisms have been implicated in hyperglyceamia-mediated vascular damage. In particular, advanced glycation endproducts (AGE), which are formed by complex, heterogeneous, sugar-derived protein modifications, have been implicated as a major pathogenic process for diabetic complications. Recently, AGE inhibitors such as aminoguanidin, ALT-946, and pyridoxamine have been reported. Such an integrating paradigm provides a new conceptual framework for future research on diabetes complications and on discovering drugs to prevent the progression of AGE-induced maladies.

Original languageEnglish
Pages (from-to)1131-1138
Number of pages8
JournalFood Science and Biotechnology
Volume17
Issue number6
Publication statusPublished - 2008 Dec 1

Fingerprint

Diabetes Complications
Pyridoxamine
pyridoxamine
amputation
blindness
myocardial infarction
renal failure
Blindness
atherosclerosis
limbs (animal)
stroke
Amputation
blood vessels
Renal Insufficiency
Blood Vessels
diabetes
Atherosclerosis
nerve tissue
Extremities
Stroke

Keywords

  • Advanced glycation endproduct
  • Diabetes mellitus
  • Diabetic complication
  • Inhibitor
  • Reactive oxygen species (ros)

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Advanced glycation endproduct-induced diabetic complications. / Lee, Hyun S.; Hong, Chung O.; Lee, Kwang Won.

In: Food Science and Biotechnology, Vol. 17, No. 6, 01.12.2008, p. 1131-1138.

Research output: Contribution to journalArticle

Lee, Hyun S. ; Hong, Chung O. ; Lee, Kwang Won. / Advanced glycation endproduct-induced diabetic complications. In: Food Science and Biotechnology. 2008 ; Vol. 17, No. 6. pp. 1131-1138.
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