Age-dependent prognostic value of body mass index for non-metastatic clear cell renal cell carcinoma: A large multicenter retrospective analysis

Seok Soo Byun, Eu C. Hwang, Seok Ho Kang, Sung Hoo Hong, Jinsoo Chung, Tae G. Kwon, Hyeon H. Kim, Cheol Kwak, Yong June Kim, Won K. Lee

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Background and Objectives: The prognostic value of obesity is unestablished for renal cell carcinoma. We assessed the age-dependent prognostic value of body mass index (BMI) in a large multicenter cohort of patients with non-metastatic clear cell renal cell carcinoma (nm-cRCC). Methods: This study evaluated 2092 patients with nm-cRCC who underwent surgery with curative intent at five Korean institutions between 2001 and 2014. Results: There was no significant difference in BMI between the young (<45 years) and older patients (≥45 years) (P = 0.398). Among older patients, high BMI (≥25 kg/m2) was associated with better 5-year rates of recurrence-free survival (RFS) and cancer-specific survival (CSS) (P = 0.003 and 0.004, respectively), and multivariate analysis confirmed that high BMI was independently associated with better RFS and CSS (RFS hazard ratio [HR]: 0.617, P = 0.005; CSS HR: 0.588, P = 0.024). However, among young patients, there were no significant BMI-related differences in the 5-year RFS and CSS rates (P = 0.457 and 0.420, respectively), and high BMI was not independently associated with RFS or CSS (P = 0.822 and 0.749, respectively). Conclusions: Among patients with nm-cRCC, high BMI was associated with a favorable prognosis among older patients but not among young patients. Therefore, the relationship between obesity and nm-cRCC prognosis might vary according to age.

Original languageEnglish
Pages (from-to)199-205
Number of pages7
JournalJournal of Surgical Oncology
Issue number1
Publication statusPublished - 2018 Jul 1



  • age
  • body mass index
  • obesity
  • renal cell carcinoma
  • survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

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