Abstract
Objective: This study was designed to compare three different measures of the elderly human brain; the magnetization transfer ratio (MTR) histogram, the percentage of brain parenchymal volume, and the volume of T2 hyperintense areas in terms of correlations with the study subjects neurocognitive performance. Materials and Methods: Thirty-five healthy community-dwelling elderly volunteers aged 60-82 years underwent dual fast spin-echo (FSE) imaging and magnetization transfer imaging. A semi-automated technique was used to generate the MTR histogram, the brain parenchymal volume, and the T2 lesion volume. The subjects' neurocognitive performance was assessed by using the Korean-Mini Mental State Examination (K-MMSE) and additional tests. The peak height of the MTR (PHMTR), the percentage of brain parenchymal volume (PBV), and the normalized T2 lesion volume (T2LV) were compared between the normal group (Z score on the K-MMSE ≥ -2, n = 23) and the mild cognitive impairment group (Z score on the K-MMSE < -2, n = 12), and these parameters were correlated with age and various neurocognitive performance scores. Results: The PHMTR was significantly lower in the cognitively impaired subjects than the PHMTR in the normal subjects (p = 0.005). The PBV scores were lower in the cognitively impaired subjects than in the normal subjects (p = 0.02). The T2LV scores were significantly higher in the cognitively impaired subjects (p = 0.01). An inverse correlation was found between the PHMTR and T2LV (r = -0.747, p < 0.001), and also between the PBV and T2LV (r = -0.823, p < 0.001). A positive correlation was observed between the PHMTR and the PBV (r = 0.846, p < 0.001). Scores on the various neurocognitive tests were positively correlated with the PHMTR (6 of 7 items) and the PBV (5 of 7 items), and they were negatively correlated with the T2LV (5 of 7 items). Conclusion: Our findings of a correlation among the PBV, the T2LV, and the PHMTR suggest that MTR histograms and the PBV and T2LV can be used as a reliable method and valid statistical tool, respectively, for quantifying the total lesion burden in an aging brain.
| Original language | English |
|---|---|
| Pages (from-to) | 96-101 |
| Number of pages | 6 |
| Journal | Korean journal of radiology |
| Volume | 5 |
| Issue number | 2 |
| Publication status | Published - 2004 Apr 1 |
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Keywords
- Brain, MRI
- Magnetic resonance (MR), magnetization transfer
- Neuropsychology
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Age-related changes in conventional and magnetization transfer MR imaging in elderly people : Comparison with neurocognitive performance. / Lee, Ki Yeol; Kim, Taik Kun; Park, Minkyu; Ko, Sungyu; In, Chan Song; Cho, Ik Hwan.
In: Korean journal of radiology, Vol. 5, No. 2, 01.04.2004, p. 96-101.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-related changes in conventional and magnetization transfer MR imaging in elderly people
T2 - Comparison with neurocognitive performance
AU - Lee, Ki Yeol
AU - Kim, Taik Kun
AU - Park, Minkyu
AU - Ko, Sungyu
AU - In, Chan Song
AU - Cho, Ik Hwan
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Objective: This study was designed to compare three different measures of the elderly human brain; the magnetization transfer ratio (MTR) histogram, the percentage of brain parenchymal volume, and the volume of T2 hyperintense areas in terms of correlations with the study subjects neurocognitive performance. Materials and Methods: Thirty-five healthy community-dwelling elderly volunteers aged 60-82 years underwent dual fast spin-echo (FSE) imaging and magnetization transfer imaging. A semi-automated technique was used to generate the MTR histogram, the brain parenchymal volume, and the T2 lesion volume. The subjects' neurocognitive performance was assessed by using the Korean-Mini Mental State Examination (K-MMSE) and additional tests. The peak height of the MTR (PHMTR), the percentage of brain parenchymal volume (PBV), and the normalized T2 lesion volume (T2LV) were compared between the normal group (Z score on the K-MMSE ≥ -2, n = 23) and the mild cognitive impairment group (Z score on the K-MMSE < -2, n = 12), and these parameters were correlated with age and various neurocognitive performance scores. Results: The PHMTR was significantly lower in the cognitively impaired subjects than the PHMTR in the normal subjects (p = 0.005). The PBV scores were lower in the cognitively impaired subjects than in the normal subjects (p = 0.02). The T2LV scores were significantly higher in the cognitively impaired subjects (p = 0.01). An inverse correlation was found between the PHMTR and T2LV (r = -0.747, p < 0.001), and also between the PBV and T2LV (r = -0.823, p < 0.001). A positive correlation was observed between the PHMTR and the PBV (r = 0.846, p < 0.001). Scores on the various neurocognitive tests were positively correlated with the PHMTR (6 of 7 items) and the PBV (5 of 7 items), and they were negatively correlated with the T2LV (5 of 7 items). Conclusion: Our findings of a correlation among the PBV, the T2LV, and the PHMTR suggest that MTR histograms and the PBV and T2LV can be used as a reliable method and valid statistical tool, respectively, for quantifying the total lesion burden in an aging brain.
AB - Objective: This study was designed to compare three different measures of the elderly human brain; the magnetization transfer ratio (MTR) histogram, the percentage of brain parenchymal volume, and the volume of T2 hyperintense areas in terms of correlations with the study subjects neurocognitive performance. Materials and Methods: Thirty-five healthy community-dwelling elderly volunteers aged 60-82 years underwent dual fast spin-echo (FSE) imaging and magnetization transfer imaging. A semi-automated technique was used to generate the MTR histogram, the brain parenchymal volume, and the T2 lesion volume. The subjects' neurocognitive performance was assessed by using the Korean-Mini Mental State Examination (K-MMSE) and additional tests. The peak height of the MTR (PHMTR), the percentage of brain parenchymal volume (PBV), and the normalized T2 lesion volume (T2LV) were compared between the normal group (Z score on the K-MMSE ≥ -2, n = 23) and the mild cognitive impairment group (Z score on the K-MMSE < -2, n = 12), and these parameters were correlated with age and various neurocognitive performance scores. Results: The PHMTR was significantly lower in the cognitively impaired subjects than the PHMTR in the normal subjects (p = 0.005). The PBV scores were lower in the cognitively impaired subjects than in the normal subjects (p = 0.02). The T2LV scores were significantly higher in the cognitively impaired subjects (p = 0.01). An inverse correlation was found between the PHMTR and T2LV (r = -0.747, p < 0.001), and also between the PBV and T2LV (r = -0.823, p < 0.001). A positive correlation was observed between the PHMTR and the PBV (r = 0.846, p < 0.001). Scores on the various neurocognitive tests were positively correlated with the PHMTR (6 of 7 items) and the PBV (5 of 7 items), and they were negatively correlated with the T2LV (5 of 7 items). Conclusion: Our findings of a correlation among the PBV, the T2LV, and the PHMTR suggest that MTR histograms and the PBV and T2LV can be used as a reliable method and valid statistical tool, respectively, for quantifying the total lesion burden in an aging brain.
KW - Brain, MRI
KW - Magnetic resonance (MR), magnetization transfer
KW - Neuropsychology
UR - http://www.scopus.com/inward/record.url?scp=3242676373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3242676373&partnerID=8YFLogxK
M3 - Article
C2 - 15235233
AN - SCOPUS:3242676373
VL - 5
SP - 96
EP - 101
JO - Korean Journal of Radiology
JF - Korean Journal of Radiology
SN - 1229-6929
IS - 2
ER -