Aging exacerbates intracerebral hemorrhage-induced brain injury

Jae Chul Lee, Geum Sil Cho, Byung Ok Choi, Hyoung Chun Kim, Won Ki Kim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aging may be an important factor affecting brain injury by intracerebral hemorrhage (ICH). In the present study, we investigated the responses of glial cells and monocytes to intracerebral hemorrhage in normal and aged rats. ICH was induced by microinjecting autologous whole blood (15μL) into the striatum of young (4 month old) and aged (24 month old) Sprague-Dawley rats. Age-dependent relations of brain tissue damage with glial and macrophageal responses were evaluated. Three days after ICH, activated microglia/macrophages with OX42-positive processes and swollen cytoplasm were more abundantly distributed around and inside the hemorrhagic lesions. These were more dramatic in aged versus the young rats. Western blot and immunohistochemistry analyses showed that the expression of interleukin-1β protein after ICH was greater in aged rats, whereas the expression of GFAP and ciliary neurotrophic factor protein after ICH was significantly lower in aged rats. These results suggest that ICH causes more severe brain injury in aged rats most likely due to overactivation of microglia/macrophages and concomitant repression of reactive astrocytes.

Original languageEnglish
Pages (from-to)1567-1576
Number of pages10
JournalJournal of Neurotrauma
Volume26
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1

Keywords

  • Aging
  • Inflammation
  • Intracerebral hemorrhage
  • Macrophages
  • Microglia

ASJC Scopus subject areas

  • Clinical Neurology

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