Agreement and Reproducibility of Proton Density Fat Fraction Measurements Using Commercial MR Sequences Across Different Platforms: A Multivendor, Multi-Institutional Phantom Experiment

Jong Keon Jang, Seung Soo Lee, Bohyun Kim, Eun Suk Cho, Yeong Jae Kim, Jae Ho Byun, Beomjin Park, So Yeon Kim, Jin Hee Kim

Research output: Contribution to journalArticle

Abstract

Objectives The aim of this study was to evaluate the agreement and reproducibility of proton density fat fraction (PDFF) measurements using commercial magnetic resonance (MR) sequences across different imagers, vendors, and field strengths via a phantom experiment. Materials and Methods Eleven fat-water emulsion phantoms of varying fat proportions (ie, 0-50 weight%) were constructed. Phantom PDFFs were estimated using commercial chemical shift-based MR imaging sequences with Siemens 1.5 T and 3.0 T, Philips 3.0 T, and GE 1.5 T and 3.0 T imagers, and MR spectroscopic sequences (HISTO) with Siemens 1.5 T and 3.0 T imagers. Agreement among the estimated PDFF values between commercial sequences was evaluated using Bland-Altman analysis. Reproducibility of the PDFF measurements across commercial sequences was evaluated using the reproducibility coefficient. The test-retest repeatability of the PDFF measurements was evaluated using the repeatability coefficient. Results The repeatability coefficient of the PDFF measurements was 0.31% to 1.58% for the absolute PDFF value for commercial sequences. Statistically significant biases in the estimated PDFF were noted in 19 of 21 pairwise comparisons of commercial sequences (range of mean biases, -4.48% to 8.15% for the absolute PDFF value). The reproducibility coefficient of PDFF measurements was 9.0% for the absolute PDFF value over all commercial sequences and 10.6% for the absolute PDFF value over all chemical shift-based MR imaging sequences. Conclusions The measurement of the PDFF is highly repeatable with commercial MR sequences but is not reproducible across different sequences, imager vendors, and field strengths. The use of the same sequence and imager is therefore recommended for the longitudinal follow-up of hepatic steatosis using commercial MR sequences for PDFF measurements.

Original languageEnglish
Pages (from-to)517-523
Number of pages7
JournalInvestigative radiology
Volume54
Issue number8
DOIs
Publication statusPublished - 2019 Aug 1

Fingerprint

Protons
Magnetic Resonance Spectroscopy
Fats
Magnetic Resonance Imaging
Emulsions

Keywords

  • commercial MR sequence
  • CS-MRI
  • hepatic steatosis
  • HISTO
  • PDFF
  • phantom study
  • reproducibility

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Agreement and Reproducibility of Proton Density Fat Fraction Measurements Using Commercial MR Sequences Across Different Platforms : A Multivendor, Multi-Institutional Phantom Experiment. / Jang, Jong Keon; Lee, Seung Soo; Kim, Bohyun; Cho, Eun Suk; Kim, Yeong Jae; Byun, Jae Ho; Park, Beomjin; Kim, So Yeon; Kim, Jin Hee.

In: Investigative radiology, Vol. 54, No. 8, 01.08.2019, p. 517-523.

Research output: Contribution to journalArticle

Jang, Jong Keon ; Lee, Seung Soo ; Kim, Bohyun ; Cho, Eun Suk ; Kim, Yeong Jae ; Byun, Jae Ho ; Park, Beomjin ; Kim, So Yeon ; Kim, Jin Hee. / Agreement and Reproducibility of Proton Density Fat Fraction Measurements Using Commercial MR Sequences Across Different Platforms : A Multivendor, Multi-Institutional Phantom Experiment. In: Investigative radiology. 2019 ; Vol. 54, No. 8. pp. 517-523.
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abstract = "Objectives The aim of this study was to evaluate the agreement and reproducibility of proton density fat fraction (PDFF) measurements using commercial magnetic resonance (MR) sequences across different imagers, vendors, and field strengths via a phantom experiment. Materials and Methods Eleven fat-water emulsion phantoms of varying fat proportions (ie, 0-50 weight{\%}) were constructed. Phantom PDFFs were estimated using commercial chemical shift-based MR imaging sequences with Siemens 1.5 T and 3.0 T, Philips 3.0 T, and GE 1.5 T and 3.0 T imagers, and MR spectroscopic sequences (HISTO) with Siemens 1.5 T and 3.0 T imagers. Agreement among the estimated PDFF values between commercial sequences was evaluated using Bland-Altman analysis. Reproducibility of the PDFF measurements across commercial sequences was evaluated using the reproducibility coefficient. The test-retest repeatability of the PDFF measurements was evaluated using the repeatability coefficient. Results The repeatability coefficient of the PDFF measurements was 0.31{\%} to 1.58{\%} for the absolute PDFF value for commercial sequences. Statistically significant biases in the estimated PDFF were noted in 19 of 21 pairwise comparisons of commercial sequences (range of mean biases, -4.48{\%} to 8.15{\%} for the absolute PDFF value). The reproducibility coefficient of PDFF measurements was 9.0{\%} for the absolute PDFF value over all commercial sequences and 10.6{\%} for the absolute PDFF value over all chemical shift-based MR imaging sequences. Conclusions The measurement of the PDFF is highly repeatable with commercial MR sequences but is not reproducible across different sequences, imager vendors, and field strengths. The use of the same sequence and imager is therefore recommended for the longitudinal follow-up of hepatic steatosis using commercial MR sequences for PDFF measurements.",
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T1 - Agreement and Reproducibility of Proton Density Fat Fraction Measurements Using Commercial MR Sequences Across Different Platforms

T2 - A Multivendor, Multi-Institutional Phantom Experiment

AU - Jang, Jong Keon

AU - Lee, Seung Soo

AU - Kim, Bohyun

AU - Cho, Eun Suk

AU - Kim, Yeong Jae

AU - Byun, Jae Ho

AU - Park, Beomjin

AU - Kim, So Yeon

AU - Kim, Jin Hee

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Objectives The aim of this study was to evaluate the agreement and reproducibility of proton density fat fraction (PDFF) measurements using commercial magnetic resonance (MR) sequences across different imagers, vendors, and field strengths via a phantom experiment. Materials and Methods Eleven fat-water emulsion phantoms of varying fat proportions (ie, 0-50 weight%) were constructed. Phantom PDFFs were estimated using commercial chemical shift-based MR imaging sequences with Siemens 1.5 T and 3.0 T, Philips 3.0 T, and GE 1.5 T and 3.0 T imagers, and MR spectroscopic sequences (HISTO) with Siemens 1.5 T and 3.0 T imagers. Agreement among the estimated PDFF values between commercial sequences was evaluated using Bland-Altman analysis. Reproducibility of the PDFF measurements across commercial sequences was evaluated using the reproducibility coefficient. The test-retest repeatability of the PDFF measurements was evaluated using the repeatability coefficient. Results The repeatability coefficient of the PDFF measurements was 0.31% to 1.58% for the absolute PDFF value for commercial sequences. Statistically significant biases in the estimated PDFF were noted in 19 of 21 pairwise comparisons of commercial sequences (range of mean biases, -4.48% to 8.15% for the absolute PDFF value). The reproducibility coefficient of PDFF measurements was 9.0% for the absolute PDFF value over all commercial sequences and 10.6% for the absolute PDFF value over all chemical shift-based MR imaging sequences. Conclusions The measurement of the PDFF is highly repeatable with commercial MR sequences but is not reproducible across different sequences, imager vendors, and field strengths. The use of the same sequence and imager is therefore recommended for the longitudinal follow-up of hepatic steatosis using commercial MR sequences for PDFF measurements.

AB - Objectives The aim of this study was to evaluate the agreement and reproducibility of proton density fat fraction (PDFF) measurements using commercial magnetic resonance (MR) sequences across different imagers, vendors, and field strengths via a phantom experiment. Materials and Methods Eleven fat-water emulsion phantoms of varying fat proportions (ie, 0-50 weight%) were constructed. Phantom PDFFs were estimated using commercial chemical shift-based MR imaging sequences with Siemens 1.5 T and 3.0 T, Philips 3.0 T, and GE 1.5 T and 3.0 T imagers, and MR spectroscopic sequences (HISTO) with Siemens 1.5 T and 3.0 T imagers. Agreement among the estimated PDFF values between commercial sequences was evaluated using Bland-Altman analysis. Reproducibility of the PDFF measurements across commercial sequences was evaluated using the reproducibility coefficient. The test-retest repeatability of the PDFF measurements was evaluated using the repeatability coefficient. Results The repeatability coefficient of the PDFF measurements was 0.31% to 1.58% for the absolute PDFF value for commercial sequences. Statistically significant biases in the estimated PDFF were noted in 19 of 21 pairwise comparisons of commercial sequences (range of mean biases, -4.48% to 8.15% for the absolute PDFF value). The reproducibility coefficient of PDFF measurements was 9.0% for the absolute PDFF value over all commercial sequences and 10.6% for the absolute PDFF value over all chemical shift-based MR imaging sequences. Conclusions The measurement of the PDFF is highly repeatable with commercial MR sequences but is not reproducible across different sequences, imager vendors, and field strengths. The use of the same sequence and imager is therefore recommended for the longitudinal follow-up of hepatic steatosis using commercial MR sequences for PDFF measurements.

KW - commercial MR sequence

KW - CS-MRI

KW - hepatic steatosis

KW - HISTO

KW - PDFF

KW - phantom study

KW - reproducibility

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