Air pollution: A new risk factor in ischemic stroke mortality

Yun Chul Hong, Jong-Tae Lee, Ho Kim, Ho Jang Kwon

Research output: Contribution to journalArticle

180 Citations (Scopus)

Abstract

Background and Purpose - Air pollution is known to be associated with cardiovascular disease, but little is known about the occurrence of stroke in relation to air pollution. We investigated the association between acute stroke mortality and air pollution over a 7-year period (January 1991 through December 1997) in Seoul, Korea. Methods - A generalized additive model was used to regress daily stroke death counts for each air pollutant, controlling for time trends, day of the week, and meteorological influences such as temperature, relative humidity, and atmospheric pressure. Ischemic and hemorrhagic stroke deaths were examined separately. Results - The effects of air pollutants on ischemic stroke mortality were statistically significant, whereas this was not the case for hemorrhagic stroke mortality. We observed estimated relative risks of 1.03 (95% CI, 1.00 to 1.06) and 1.04 (95% CI, 1.01 to 1.08) for ischemic stroke mortality for each interquartile range increase in total suspended particulates and sulfur dioxide concentrations on the same day. We also found significantly increased relative risks of 1.04 (95% CI, 1.01 to 1.07) for nitrogen dioxide with a 1-day lag, of 1.06 (95% CI, 1.02 to 1.09) for carbon monoxide with a 1-day lag, and of 1.06 (95% CI, 1.02 to 1.10) for ozone with a 3-day lag for each interquartile range increase. Conclusions - These findings indicate that air pollutants are significantly associated with ischemic stroke mortality, which suggests an acute pathogenetic process in the cerebrovascular system induced by air pollution.

Original languageEnglish
Pages (from-to)2165-2169
Number of pages5
JournalStroke
Volume33
Issue number9
DOIs
Publication statusPublished - 2002 Sep 1
Externally publishedYes

Fingerprint

Air Pollution
Stroke
Mortality
Air Pollutants
Nitrogen Dioxide
Sulfur Dioxide
Atmospheric Pressure
Ozone
Carbon Monoxide
Korea
Humidity
Cardiovascular Diseases
Temperature

Keywords

  • Air pollution
  • Mortality
  • Stroke, hemorrhagic
  • Stroke, ischemic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Air pollution : A new risk factor in ischemic stroke mortality. / Hong, Yun Chul; Lee, Jong-Tae; Kim, Ho; Kwon, Ho Jang.

In: Stroke, Vol. 33, No. 9, 01.09.2002, p. 2165-2169.

Research output: Contribution to journalArticle

Hong, Yun Chul ; Lee, Jong-Tae ; Kim, Ho ; Kwon, Ho Jang. / Air pollution : A new risk factor in ischemic stroke mortality. In: Stroke. 2002 ; Vol. 33, No. 9. pp. 2165-2169.
@article{5ae20d707a234f2992a0c2588168c4eb,
title = "Air pollution: A new risk factor in ischemic stroke mortality",
abstract = "Background and Purpose - Air pollution is known to be associated with cardiovascular disease, but little is known about the occurrence of stroke in relation to air pollution. We investigated the association between acute stroke mortality and air pollution over a 7-year period (January 1991 through December 1997) in Seoul, Korea. Methods - A generalized additive model was used to regress daily stroke death counts for each air pollutant, controlling for time trends, day of the week, and meteorological influences such as temperature, relative humidity, and atmospheric pressure. Ischemic and hemorrhagic stroke deaths were examined separately. Results - The effects of air pollutants on ischemic stroke mortality were statistically significant, whereas this was not the case for hemorrhagic stroke mortality. We observed estimated relative risks of 1.03 (95{\%} CI, 1.00 to 1.06) and 1.04 (95{\%} CI, 1.01 to 1.08) for ischemic stroke mortality for each interquartile range increase in total suspended particulates and sulfur dioxide concentrations on the same day. We also found significantly increased relative risks of 1.04 (95{\%} CI, 1.01 to 1.07) for nitrogen dioxide with a 1-day lag, of 1.06 (95{\%} CI, 1.02 to 1.09) for carbon monoxide with a 1-day lag, and of 1.06 (95{\%} CI, 1.02 to 1.10) for ozone with a 3-day lag for each interquartile range increase. Conclusions - These findings indicate that air pollutants are significantly associated with ischemic stroke mortality, which suggests an acute pathogenetic process in the cerebrovascular system induced by air pollution.",
keywords = "Air pollution, Mortality, Stroke, hemorrhagic, Stroke, ischemic",
author = "Hong, {Yun Chul} and Jong-Tae Lee and Ho Kim and Kwon, {Ho Jang}",
year = "2002",
month = "9",
day = "1",
doi = "10.1161/01.STR.0000026865.52610.5B",
language = "English",
volume = "33",
pages = "2165--2169",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Air pollution

T2 - A new risk factor in ischemic stroke mortality

AU - Hong, Yun Chul

AU - Lee, Jong-Tae

AU - Kim, Ho

AU - Kwon, Ho Jang

PY - 2002/9/1

Y1 - 2002/9/1

N2 - Background and Purpose - Air pollution is known to be associated with cardiovascular disease, but little is known about the occurrence of stroke in relation to air pollution. We investigated the association between acute stroke mortality and air pollution over a 7-year period (January 1991 through December 1997) in Seoul, Korea. Methods - A generalized additive model was used to regress daily stroke death counts for each air pollutant, controlling for time trends, day of the week, and meteorological influences such as temperature, relative humidity, and atmospheric pressure. Ischemic and hemorrhagic stroke deaths were examined separately. Results - The effects of air pollutants on ischemic stroke mortality were statistically significant, whereas this was not the case for hemorrhagic stroke mortality. We observed estimated relative risks of 1.03 (95% CI, 1.00 to 1.06) and 1.04 (95% CI, 1.01 to 1.08) for ischemic stroke mortality for each interquartile range increase in total suspended particulates and sulfur dioxide concentrations on the same day. We also found significantly increased relative risks of 1.04 (95% CI, 1.01 to 1.07) for nitrogen dioxide with a 1-day lag, of 1.06 (95% CI, 1.02 to 1.09) for carbon monoxide with a 1-day lag, and of 1.06 (95% CI, 1.02 to 1.10) for ozone with a 3-day lag for each interquartile range increase. Conclusions - These findings indicate that air pollutants are significantly associated with ischemic stroke mortality, which suggests an acute pathogenetic process in the cerebrovascular system induced by air pollution.

AB - Background and Purpose - Air pollution is known to be associated with cardiovascular disease, but little is known about the occurrence of stroke in relation to air pollution. We investigated the association between acute stroke mortality and air pollution over a 7-year period (January 1991 through December 1997) in Seoul, Korea. Methods - A generalized additive model was used to regress daily stroke death counts for each air pollutant, controlling for time trends, day of the week, and meteorological influences such as temperature, relative humidity, and atmospheric pressure. Ischemic and hemorrhagic stroke deaths were examined separately. Results - The effects of air pollutants on ischemic stroke mortality were statistically significant, whereas this was not the case for hemorrhagic stroke mortality. We observed estimated relative risks of 1.03 (95% CI, 1.00 to 1.06) and 1.04 (95% CI, 1.01 to 1.08) for ischemic stroke mortality for each interquartile range increase in total suspended particulates and sulfur dioxide concentrations on the same day. We also found significantly increased relative risks of 1.04 (95% CI, 1.01 to 1.07) for nitrogen dioxide with a 1-day lag, of 1.06 (95% CI, 1.02 to 1.09) for carbon monoxide with a 1-day lag, and of 1.06 (95% CI, 1.02 to 1.10) for ozone with a 3-day lag for each interquartile range increase. Conclusions - These findings indicate that air pollutants are significantly associated with ischemic stroke mortality, which suggests an acute pathogenetic process in the cerebrovascular system induced by air pollution.

KW - Air pollution

KW - Mortality

KW - Stroke, hemorrhagic

KW - Stroke, ischemic

UR - http://www.scopus.com/inward/record.url?scp=0036715217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036715217&partnerID=8YFLogxK

U2 - 10.1161/01.STR.0000026865.52610.5B

DO - 10.1161/01.STR.0000026865.52610.5B

M3 - Article

C2 - 12215581

AN - SCOPUS:0036715217

VL - 33

SP - 2165

EP - 2169

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 9

ER -