Air pollution and skin diseases: Adverse effects of airborne particulate matter on various skin diseases

Kyung Eun Kim, Dae Ho Cho, Hyun Jeong Park

Research output: Contribution to journalReview article

99 Citations (Scopus)

Abstract

Environmental air pollution encompasses various particulate matters (PMs). The increased ambient PM from industrialization and urbanization is highly associated with morbidity and mortality worldwide, presenting one of the most severe environmental pollution problems. This article focuses on the correlation between PM and skin diseases, along with related immunological mechanisms. Recent epidemiological studies on the cutaneous impacts of PM showed that PM affects the development and exacerbation of skin diseases. PM induces oxidative stress via production of reactive oxygen species and secretion of pro-inflammatory cytokines such as TNF-α, IL-1α, and IL-8. In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. These processes lead to the increased inflammatory skin diseases and skin aging. In addition, environmental cigarette smoke, which is well known as an oxidizing agent, is closely related with androgenetic alopecia (AGA). Also, ultrafine particles (UFPs) including black carbon and polycyclic aromatic hydrocarbons (PAHs) enhance the incidence of skin cancer. Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines. Therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.

Original languageEnglish
Pages (from-to)126-134
Number of pages9
JournalLife Sciences
Volume152
DOIs
Publication statusPublished - 2016 May 1
Externally publishedYes

Fingerprint

Particulate Matter
Air Pollution
Air pollution
Skin Diseases
Skin
Matrix Metalloproteinases
Environmental Pollution
Oxidative stress
Oxidants
Oxidative Stress
Cytokines
Soot
Skin Aging
Urbanization
Polycyclic Aromatic Hydrocarbons
Alopecia
Skin Neoplasms
Interleukin-8
Interleukin-1
Smoke

Keywords

  • Aging
  • Alopecia
  • Oxidative stress
  • Particulate matter Inflammatory skin diseases
  • Pro-inflammatory cytokine
  • Skin cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Air pollution and skin diseases : Adverse effects of airborne particulate matter on various skin diseases. / Kim, Kyung Eun; Cho, Dae Ho; Park, Hyun Jeong.

In: Life Sciences, Vol. 152, 01.05.2016, p. 126-134.

Research output: Contribution to journalReview article

@article{3d8332ae18c74ee4a61659eebbc71fb5,
title = "Air pollution and skin diseases: Adverse effects of airborne particulate matter on various skin diseases",
abstract = "Environmental air pollution encompasses various particulate matters (PMs). The increased ambient PM from industrialization and urbanization is highly associated with morbidity and mortality worldwide, presenting one of the most severe environmental pollution problems. This article focuses on the correlation between PM and skin diseases, along with related immunological mechanisms. Recent epidemiological studies on the cutaneous impacts of PM showed that PM affects the development and exacerbation of skin diseases. PM induces oxidative stress via production of reactive oxygen species and secretion of pro-inflammatory cytokines such as TNF-α, IL-1α, and IL-8. In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. These processes lead to the increased inflammatory skin diseases and skin aging. In addition, environmental cigarette smoke, which is well known as an oxidizing agent, is closely related with androgenetic alopecia (AGA). Also, ultrafine particles (UFPs) including black carbon and polycyclic aromatic hydrocarbons (PAHs) enhance the incidence of skin cancer. Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines. Therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.",
keywords = "Aging, Alopecia, Oxidative stress, Particulate matter Inflammatory skin diseases, Pro-inflammatory cytokine, Skin cancer",
author = "Kim, {Kyung Eun} and Cho, {Dae Ho} and Park, {Hyun Jeong}",
year = "2016",
month = "5",
day = "1",
doi = "10.1016/j.lfs.2016.03.039",
language = "English",
volume = "152",
pages = "126--134",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Air pollution and skin diseases

T2 - Adverse effects of airborne particulate matter on various skin diseases

AU - Kim, Kyung Eun

AU - Cho, Dae Ho

AU - Park, Hyun Jeong

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Environmental air pollution encompasses various particulate matters (PMs). The increased ambient PM from industrialization and urbanization is highly associated with morbidity and mortality worldwide, presenting one of the most severe environmental pollution problems. This article focuses on the correlation between PM and skin diseases, along with related immunological mechanisms. Recent epidemiological studies on the cutaneous impacts of PM showed that PM affects the development and exacerbation of skin diseases. PM induces oxidative stress via production of reactive oxygen species and secretion of pro-inflammatory cytokines such as TNF-α, IL-1α, and IL-8. In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. These processes lead to the increased inflammatory skin diseases and skin aging. In addition, environmental cigarette smoke, which is well known as an oxidizing agent, is closely related with androgenetic alopecia (AGA). Also, ultrafine particles (UFPs) including black carbon and polycyclic aromatic hydrocarbons (PAHs) enhance the incidence of skin cancer. Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines. Therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.

AB - Environmental air pollution encompasses various particulate matters (PMs). The increased ambient PM from industrialization and urbanization is highly associated with morbidity and mortality worldwide, presenting one of the most severe environmental pollution problems. This article focuses on the correlation between PM and skin diseases, along with related immunological mechanisms. Recent epidemiological studies on the cutaneous impacts of PM showed that PM affects the development and exacerbation of skin diseases. PM induces oxidative stress via production of reactive oxygen species and secretion of pro-inflammatory cytokines such as TNF-α, IL-1α, and IL-8. In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. These processes lead to the increased inflammatory skin diseases and skin aging. In addition, environmental cigarette smoke, which is well known as an oxidizing agent, is closely related with androgenetic alopecia (AGA). Also, ultrafine particles (UFPs) including black carbon and polycyclic aromatic hydrocarbons (PAHs) enhance the incidence of skin cancer. Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines. Therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.

KW - Aging

KW - Alopecia

KW - Oxidative stress

KW - Particulate matter Inflammatory skin diseases

KW - Pro-inflammatory cytokine

KW - Skin cancer

UR - http://www.scopus.com/inward/record.url?scp=84962892909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962892909&partnerID=8YFLogxK

U2 - 10.1016/j.lfs.2016.03.039

DO - 10.1016/j.lfs.2016.03.039

M3 - Review article

C2 - 27018067

AN - SCOPUS:84962892909

VL - 152

SP - 126

EP - 134

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

ER -