Abstract
Environmental air pollution encompasses various particulate matters (PMs). The increased ambient PM from industrialization and urbanization is highly associated with morbidity and mortality worldwide, presenting one of the most severe environmental pollution problems. This article focuses on the correlation between PM and skin diseases, along with related immunological mechanisms. Recent epidemiological studies on the cutaneous impacts of PM showed that PM affects the development and exacerbation of skin diseases. PM induces oxidative stress via production of reactive oxygen species and secretion of pro-inflammatory cytokines such as TNF-α, IL-1α, and IL-8. In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. These processes lead to the increased inflammatory skin diseases and skin aging. In addition, environmental cigarette smoke, which is well known as an oxidizing agent, is closely related with androgenetic alopecia (AGA). Also, ultrafine particles (UFPs) including black carbon and polycyclic aromatic hydrocarbons (PAHs) enhance the incidence of skin cancer. Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines. Therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 126-134 |
| Number of pages | 9 |
| Journal | Life Sciences |
| Volume | 152 |
| DOIs | |
| Publication status | Published - 2016 May 1 |
| Externally published | Yes |
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Keywords
- Aging
- Alopecia
- Oxidative stress
- Particulate matter Inflammatory skin diseases
- Pro-inflammatory cytokine
- Skin cancer
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Air pollution and skin diseases : Adverse effects of airborne particulate matter on various skin diseases. / Kim, Kyung Eun; Cho, Dae Ho; Park, Hyun Jeong.
In: Life Sciences, Vol. 152, 01.05.2016, p. 126-134.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Air pollution and skin diseases
T2 - Adverse effects of airborne particulate matter on various skin diseases
AU - Kim, Kyung Eun
AU - Cho, Dae Ho
AU - Park, Hyun Jeong
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Environmental air pollution encompasses various particulate matters (PMs). The increased ambient PM from industrialization and urbanization is highly associated with morbidity and mortality worldwide, presenting one of the most severe environmental pollution problems. This article focuses on the correlation between PM and skin diseases, along with related immunological mechanisms. Recent epidemiological studies on the cutaneous impacts of PM showed that PM affects the development and exacerbation of skin diseases. PM induces oxidative stress via production of reactive oxygen species and secretion of pro-inflammatory cytokines such as TNF-α, IL-1α, and IL-8. In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. These processes lead to the increased inflammatory skin diseases and skin aging. In addition, environmental cigarette smoke, which is well known as an oxidizing agent, is closely related with androgenetic alopecia (AGA). Also, ultrafine particles (UFPs) including black carbon and polycyclic aromatic hydrocarbons (PAHs) enhance the incidence of skin cancer. Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines. Therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.
AB - Environmental air pollution encompasses various particulate matters (PMs). The increased ambient PM from industrialization and urbanization is highly associated with morbidity and mortality worldwide, presenting one of the most severe environmental pollution problems. This article focuses on the correlation between PM and skin diseases, along with related immunological mechanisms. Recent epidemiological studies on the cutaneous impacts of PM showed that PM affects the development and exacerbation of skin diseases. PM induces oxidative stress via production of reactive oxygen species and secretion of pro-inflammatory cytokines such as TNF-α, IL-1α, and IL-8. In addition, the increased production of ROS such as superoxide and hydroxyl radical by PM exposure increases MMPs including MMP-1, MMP-2, and MMP-9, resulting in the degradation of collagen. These processes lead to the increased inflammatory skin diseases and skin aging. In addition, environmental cigarette smoke, which is well known as an oxidizing agent, is closely related with androgenetic alopecia (AGA). Also, ultrafine particles (UFPs) including black carbon and polycyclic aromatic hydrocarbons (PAHs) enhance the incidence of skin cancer. Overall, increased PM levels are highly associated with the development of various skin diseases via the regulation of oxidative stress and inflammatory cytokines. Therefore, anti-oxidant and anti-inflammatory drugs may be useful for treating PM-induced skin diseases.
KW - Aging
KW - Alopecia
KW - Oxidative stress
KW - Particulate matter Inflammatory skin diseases
KW - Pro-inflammatory cytokine
KW - Skin cancer
UR - http://www.scopus.com/inward/record.url?scp=84962892909&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962892909&partnerID=8YFLogxK
U2 - 10.1016/j.lfs.2016.03.039
DO - 10.1016/j.lfs.2016.03.039
M3 - Review article
C2 - 27018067
AN - SCOPUS:84962892909
VL - 152
SP - 126
EP - 134
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
ER -