Alachlor use and cancer incidence in the agricultural health study: An updated analysis

Catherine C. Lerro, Gabriella Andreotti, Stella Koutros, Won Jin Lee, Jonathan N. Hofmann, Dale P. Sandler, Christine G. Parks, Aaron Blair, Jay H. Lubin, Laura E. Beane Freeman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The herbicide alachlor has been widely used in US agriculture since its introduction in 1969. Experimental animal studies show that alachlor causes tumors in vivo; however, few epidemiologic studies have examined associations with human cancer risk. We evaluated alachlor use and cancer incidence in the Agricultural Health Study, updating an earlier analysis that suggested associations with lymphohematopoietic cancers with an additional 540 142 person-years of follow-up and 5113 cancer cases. Methods: Pesticide applicators in Iowa and North Carolina reported lifetime alachlor use at enrollment (1993 1997) and follow-up (1999 2005). Exposure was characterized by cumulative intensity-weighted days. We estimated relative risks (RRs) and 95% confidence intervals (CIs) using Poisson regression for incident cancers from enrollment through 2012(NC)/2013(IA). Models adjusted for age, tobacco, alcohol, and other pesticides. All statistical tests are two-sided. Results: Among 49 685 applicators, 25 640 (51.6%) used alachlor, with 3534 alachlor-exposed cancers. The relative risks of laryngeal cancer (nexposed 34) increased in the second (RR 4.68, 95% CI 1.95 to 11.23), third (RR 6.04, 95% CI 2.44 to 14.99), and fourth quartiles (RR 7.10, 95% CI 2.58 to 19.53) of intensity-weighted days of use compared with no use (Ptrend .001). Risk of myeloid leukemia was elevated, though not statistically significantly so, in the fourth quartile of intensityweighted days of use (RR 1.82, 95% CI 0.85 to 3.87, Ptrend .17). Conclusions: We observed a strong positive association with use of alachlor and laryngeal cancer and a weaker association with myeloid leukemia. The strength and robustness of the association with laryngeal cancer suggests that long-termoccupational exposure to alachlor may be a risk factor for laryngeal cancer. This first report requires confirmation.

Original languageEnglish
Pages (from-to)950-958
Number of pages9
JournalJournal of the National Cancer Institute
Volume110
Issue number9
DOIs
Publication statusPublished - 2018 Sep 1

Fingerprint

Laryngeal Neoplasms
Incidence
Health
Confidence Intervals
Neoplasms
Myeloid Leukemia
Pesticides
alachlor
Herbicides
Agriculture
Tobacco
Epidemiologic Studies
Alcohols

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lerro, C. C., Andreotti, G., Koutros, S., Lee, W. J., Hofmann, J. N., Sandler, D. P., ... Beane Freeman, L. E. (2018). Alachlor use and cancer incidence in the agricultural health study: An updated analysis. Journal of the National Cancer Institute, 110(9), 950-958. https://doi.org/10.1093/jnci/djy005

Alachlor use and cancer incidence in the agricultural health study : An updated analysis. / Lerro, Catherine C.; Andreotti, Gabriella; Koutros, Stella; Lee, Won Jin; Hofmann, Jonathan N.; Sandler, Dale P.; Parks, Christine G.; Blair, Aaron; Lubin, Jay H.; Beane Freeman, Laura E.

In: Journal of the National Cancer Institute, Vol. 110, No. 9, 01.09.2018, p. 950-958.

Research output: Contribution to journalArticle

Lerro, CC, Andreotti, G, Koutros, S, Lee, WJ, Hofmann, JN, Sandler, DP, Parks, CG, Blair, A, Lubin, JH & Beane Freeman, LE 2018, 'Alachlor use and cancer incidence in the agricultural health study: An updated analysis', Journal of the National Cancer Institute, vol. 110, no. 9, pp. 950-958. https://doi.org/10.1093/jnci/djy005
Lerro, Catherine C. ; Andreotti, Gabriella ; Koutros, Stella ; Lee, Won Jin ; Hofmann, Jonathan N. ; Sandler, Dale P. ; Parks, Christine G. ; Blair, Aaron ; Lubin, Jay H. ; Beane Freeman, Laura E. / Alachlor use and cancer incidence in the agricultural health study : An updated analysis. In: Journal of the National Cancer Institute. 2018 ; Vol. 110, No. 9. pp. 950-958.
@article{5c9d30e7bdac490a8d0202012428b8c4,
title = "Alachlor use and cancer incidence in the agricultural health study: An updated analysis",
abstract = "Background: The herbicide alachlor has been widely used in US agriculture since its introduction in 1969. Experimental animal studies show that alachlor causes tumors in vivo; however, few epidemiologic studies have examined associations with human cancer risk. We evaluated alachlor use and cancer incidence in the Agricultural Health Study, updating an earlier analysis that suggested associations with lymphohematopoietic cancers with an additional 540 142 person-years of follow-up and 5113 cancer cases. Methods: Pesticide applicators in Iowa and North Carolina reported lifetime alachlor use at enrollment (1993 1997) and follow-up (1999 2005). Exposure was characterized by cumulative intensity-weighted days. We estimated relative risks (RRs) and 95{\%} confidence intervals (CIs) using Poisson regression for incident cancers from enrollment through 2012(NC)/2013(IA). Models adjusted for age, tobacco, alcohol, and other pesticides. All statistical tests are two-sided. Results: Among 49 685 applicators, 25 640 (51.6{\%}) used alachlor, with 3534 alachlor-exposed cancers. The relative risks of laryngeal cancer (nexposed 34) increased in the second (RR 4.68, 95{\%} CI 1.95 to 11.23), third (RR 6.04, 95{\%} CI 2.44 to 14.99), and fourth quartiles (RR 7.10, 95{\%} CI 2.58 to 19.53) of intensity-weighted days of use compared with no use (Ptrend .001). Risk of myeloid leukemia was elevated, though not statistically significantly so, in the fourth quartile of intensityweighted days of use (RR 1.82, 95{\%} CI 0.85 to 3.87, Ptrend .17). Conclusions: We observed a strong positive association with use of alachlor and laryngeal cancer and a weaker association with myeloid leukemia. The strength and robustness of the association with laryngeal cancer suggests that long-termoccupational exposure to alachlor may be a risk factor for laryngeal cancer. This first report requires confirmation.",
author = "Lerro, {Catherine C.} and Gabriella Andreotti and Stella Koutros and Lee, {Won Jin} and Hofmann, {Jonathan N.} and Sandler, {Dale P.} and Parks, {Christine G.} and Aaron Blair and Lubin, {Jay H.} and {Beane Freeman}, {Laura E.}",
year = "2018",
month = "9",
day = "1",
doi = "10.1093/jnci/djy005",
language = "English",
volume = "110",
pages = "950--958",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Alachlor use and cancer incidence in the agricultural health study

T2 - An updated analysis

AU - Lerro, Catherine C.

AU - Andreotti, Gabriella

AU - Koutros, Stella

AU - Lee, Won Jin

AU - Hofmann, Jonathan N.

AU - Sandler, Dale P.

AU - Parks, Christine G.

AU - Blair, Aaron

AU - Lubin, Jay H.

AU - Beane Freeman, Laura E.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: The herbicide alachlor has been widely used in US agriculture since its introduction in 1969. Experimental animal studies show that alachlor causes tumors in vivo; however, few epidemiologic studies have examined associations with human cancer risk. We evaluated alachlor use and cancer incidence in the Agricultural Health Study, updating an earlier analysis that suggested associations with lymphohematopoietic cancers with an additional 540 142 person-years of follow-up and 5113 cancer cases. Methods: Pesticide applicators in Iowa and North Carolina reported lifetime alachlor use at enrollment (1993 1997) and follow-up (1999 2005). Exposure was characterized by cumulative intensity-weighted days. We estimated relative risks (RRs) and 95% confidence intervals (CIs) using Poisson regression for incident cancers from enrollment through 2012(NC)/2013(IA). Models adjusted for age, tobacco, alcohol, and other pesticides. All statistical tests are two-sided. Results: Among 49 685 applicators, 25 640 (51.6%) used alachlor, with 3534 alachlor-exposed cancers. The relative risks of laryngeal cancer (nexposed 34) increased in the second (RR 4.68, 95% CI 1.95 to 11.23), third (RR 6.04, 95% CI 2.44 to 14.99), and fourth quartiles (RR 7.10, 95% CI 2.58 to 19.53) of intensity-weighted days of use compared with no use (Ptrend .001). Risk of myeloid leukemia was elevated, though not statistically significantly so, in the fourth quartile of intensityweighted days of use (RR 1.82, 95% CI 0.85 to 3.87, Ptrend .17). Conclusions: We observed a strong positive association with use of alachlor and laryngeal cancer and a weaker association with myeloid leukemia. The strength and robustness of the association with laryngeal cancer suggests that long-termoccupational exposure to alachlor may be a risk factor for laryngeal cancer. This first report requires confirmation.

AB - Background: The herbicide alachlor has been widely used in US agriculture since its introduction in 1969. Experimental animal studies show that alachlor causes tumors in vivo; however, few epidemiologic studies have examined associations with human cancer risk. We evaluated alachlor use and cancer incidence in the Agricultural Health Study, updating an earlier analysis that suggested associations with lymphohematopoietic cancers with an additional 540 142 person-years of follow-up and 5113 cancer cases. Methods: Pesticide applicators in Iowa and North Carolina reported lifetime alachlor use at enrollment (1993 1997) and follow-up (1999 2005). Exposure was characterized by cumulative intensity-weighted days. We estimated relative risks (RRs) and 95% confidence intervals (CIs) using Poisson regression for incident cancers from enrollment through 2012(NC)/2013(IA). Models adjusted for age, tobacco, alcohol, and other pesticides. All statistical tests are two-sided. Results: Among 49 685 applicators, 25 640 (51.6%) used alachlor, with 3534 alachlor-exposed cancers. The relative risks of laryngeal cancer (nexposed 34) increased in the second (RR 4.68, 95% CI 1.95 to 11.23), third (RR 6.04, 95% CI 2.44 to 14.99), and fourth quartiles (RR 7.10, 95% CI 2.58 to 19.53) of intensity-weighted days of use compared with no use (Ptrend .001). Risk of myeloid leukemia was elevated, though not statistically significantly so, in the fourth quartile of intensityweighted days of use (RR 1.82, 95% CI 0.85 to 3.87, Ptrend .17). Conclusions: We observed a strong positive association with use of alachlor and laryngeal cancer and a weaker association with myeloid leukemia. The strength and robustness of the association with laryngeal cancer suggests that long-termoccupational exposure to alachlor may be a risk factor for laryngeal cancer. This first report requires confirmation.

UR - http://www.scopus.com/inward/record.url?scp=85054095121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054095121&partnerID=8YFLogxK

U2 - 10.1093/jnci/djy005

DO - 10.1093/jnci/djy005

M3 - Article

C2 - 29471327

AN - SCOPUS:85054095121

VL - 110

SP - 950

EP - 958

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 9

ER -