ALBI versus Child-Pugh grading systems for liver function in patients with hepatocellular carcinoma

Seong K. Na, Sun Y. Yim, Sang J. Suh, Young K. Jung, Ji H. Kim, Yeon S. Seo, Hyung J. Yim, Jong E. Yeon, Kwan S. Byun, Soon H. Um

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    23 Citations (Scopus)

    Abstract

    Background: The prognostic performance of the albumin-bilirubin (ALBI) grade in hepatocellular carcinoma (HCC) as an objective method of assessing liver function was investigated. Methods: Data from 2099 patients with HCC in Korea were collected and analyzed retrospectively. The discriminative performance of ALBI grade was compared with Child-Pugh (C-P) grade for different stages or treatments. Results: The median follow up duration was 16.2 months (range: 1.0-124.9). The median survival times were 49.7 months for C-P grade A (65.8%), 12.4 months for C-P grade B (25.5%), and 4.2 months for C-P grade C (8.6%) (P < 0.001). The median survival times were 84.2 months for ALBI grade 1 (32.8%), 25.5 months for ALBI grade 2 (53.5%), and 7.7 months for ALBI grade 3 (13.7%) (P < 0.001). In early UICC stages, ALBI grade showed better discriminative performance than C-P grade. In curative treatments, ALBI grade also showed better discriminative performance than C-P grade (Harrell's C: 0.624 (C-P grade) vs 0.667 [ALBI grade]). Conclusions: ALBI grade provided better prognostic performance in survival analysis and better distribution of the grades than C-P grade in HCC, suggesting that ALBI grade could be a good alternative grading system for liver function in patients with HCC.

    Original languageEnglish
    Pages (from-to)912-921
    Number of pages10
    JournalJournal of Surgical Oncology
    Volume117
    Issue number5
    DOIs
    Publication statusPublished - 2018 Apr 1

    Keywords

    • ALBI grade
    • Child-Pugh grade
    • hepatocellular carcinoma
    • prognosis
    • survival

    ASJC Scopus subject areas

    • Surgery
    • Oncology

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