ALBI versus Child-Pugh grading systems for liver function in patients with hepatocellular carcinoma

Seong K. Na, Sun Y. Yim, Sang J. Suh, Young Kul Jung, Ji Hoon Kim, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun, Soon-Ho Um

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14 Citations (Scopus)

Abstract

Background: The prognostic performance of the albumin-bilirubin (ALBI) grade in hepatocellular carcinoma (HCC) as an objective method of assessing liver function was investigated. Methods: Data from 2099 patients with HCC in Korea were collected and analyzed retrospectively. The discriminative performance of ALBI grade was compared with Child-Pugh (C-P) grade for different stages or treatments. Results: The median follow up duration was 16.2 months (range: 1.0-124.9). The median survival times were 49.7 months for C-P grade A (65.8%), 12.4 months for C-P grade B (25.5%), and 4.2 months for C-P grade C (8.6%) (P < 0.001). The median survival times were 84.2 months for ALBI grade 1 (32.8%), 25.5 months for ALBI grade 2 (53.5%), and 7.7 months for ALBI grade 3 (13.7%) (P < 0.001). In early UICC stages, ALBI grade showed better discriminative performance than C-P grade. In curative treatments, ALBI grade also showed better discriminative performance than C-P grade (Harrell's C: 0.624 (C-P grade) vs 0.667 [ALBI grade]). Conclusions: ALBI grade provided better prognostic performance in survival analysis and better distribution of the grades than C-P grade in HCC, suggesting that ALBI grade could be a good alternative grading system for liver function in patients with HCC.

Original languageEnglish
Pages (from-to)912-921
Number of pages10
JournalJournal of Surgical Oncology
Volume117
Issue number5
DOIs
Publication statusPublished - 2018 Apr 1

Keywords

  • ALBI grade
  • Child-Pugh grade
  • hepatocellular carcinoma
  • prognosis
  • survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Na, S. K., Yim, S. Y., Suh, S. J., Jung, Y. K., Kim, J. H., Seo, Y. S., Yim, H. J., Yeon, J. E., Byun, K. S., & Um, S-H. (2018). ALBI versus Child-Pugh grading systems for liver function in patients with hepatocellular carcinoma. Journal of Surgical Oncology, 117(5), 912-921. https://doi.org/10.1002/jso.24992