Albumin versus normal saline for dehydrated term infants with metabolic acidosis due to acute diarrhea

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Abstract

Objective: To compare the efficacy of albumin to normal saline (NS) for initial hydration therapy for dehydrated term infants with severe metabolic acidosis due to acute diarrhea. Study Design: We randomized 33 infants presenting with moderate-to-severe dehydration and metabolic acidosis (pH < 7.25 or base excess (BE) <-15) into two groups, an albumin group (n = 15) and a NS group (n = 18). For initial hydration treatment, the albumin group received 5% albumin (10mlkg-1), whereas the NS group received NS (10 ml kg-1). Result: After 3h of treatment, both groups improved. However, the magnitude of improvement in the pH, BE and HCO3- levels were not different in comparisons between these two groups. In addition, there were no differences either in the body weight and weight gain 4 days after treatment or in the length of hospital stay. Conclusion: Albumin was not more effective than NS for initial hydration treatment of dehydrated term infants with metabolic acidosis due to acute diarrhea.

Original languageEnglish
Pages (from-to)444-447
Number of pages4
JournalJournal of Perinatology
Volume29
Issue number6
DOIs
Publication statusPublished - 2009 Jan 23

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Acidosis
Albumins
Diarrhea
Length of Stay
Therapeutics
Dehydration
Weight Gain
Body Weight

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

@article{0ab38ca3525646f3980944e410373e5d,
title = "Albumin versus normal saline for dehydrated term infants with metabolic acidosis due to acute diarrhea",
abstract = "Objective: To compare the efficacy of albumin to normal saline (NS) for initial hydration therapy for dehydrated term infants with severe metabolic acidosis due to acute diarrhea. Study Design: We randomized 33 infants presenting with moderate-to-severe dehydration and metabolic acidosis (pH < 7.25 or base excess (BE) <-15) into two groups, an albumin group (n = 15) and a NS group (n = 18). For initial hydration treatment, the albumin group received 5{\%} albumin (10mlkg-1), whereas the NS group received NS (10 ml kg-1). Result: After 3h of treatment, both groups improved. However, the magnitude of improvement in the pH, BE and HCO3- levels were not different in comparisons between these two groups. In addition, there were no differences either in the body weight and weight gain 4 days after treatment or in the length of hospital stay. Conclusion: Albumin was not more effective than NS for initial hydration treatment of dehydrated term infants with metabolic acidosis due to acute diarrhea.",
author = "Han, {J. J.} and Hyung-Eun Yim and Lee, {Jung Hwa} and Kim, {Yun Kyung} and Giyoung Jang and Choi, {Byung Min} and Yoo, {Kee Hwan} and Hong, {Young Sook}",
year = "2009",
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T1 - Albumin versus normal saline for dehydrated term infants with metabolic acidosis due to acute diarrhea

AU - Han, J. J.

AU - Yim, Hyung-Eun

AU - Lee, Jung Hwa

AU - Kim, Yun Kyung

AU - Jang, Giyoung

AU - Choi, Byung Min

AU - Yoo, Kee Hwan

AU - Hong, Young Sook

PY - 2009/1/23

Y1 - 2009/1/23

N2 - Objective: To compare the efficacy of albumin to normal saline (NS) for initial hydration therapy for dehydrated term infants with severe metabolic acidosis due to acute diarrhea. Study Design: We randomized 33 infants presenting with moderate-to-severe dehydration and metabolic acidosis (pH < 7.25 or base excess (BE) <-15) into two groups, an albumin group (n = 15) and a NS group (n = 18). For initial hydration treatment, the albumin group received 5% albumin (10mlkg-1), whereas the NS group received NS (10 ml kg-1). Result: After 3h of treatment, both groups improved. However, the magnitude of improvement in the pH, BE and HCO3- levels were not different in comparisons between these two groups. In addition, there were no differences either in the body weight and weight gain 4 days after treatment or in the length of hospital stay. Conclusion: Albumin was not more effective than NS for initial hydration treatment of dehydrated term infants with metabolic acidosis due to acute diarrhea.

AB - Objective: To compare the efficacy of albumin to normal saline (NS) for initial hydration therapy for dehydrated term infants with severe metabolic acidosis due to acute diarrhea. Study Design: We randomized 33 infants presenting with moderate-to-severe dehydration and metabolic acidosis (pH < 7.25 or base excess (BE) <-15) into two groups, an albumin group (n = 15) and a NS group (n = 18). For initial hydration treatment, the albumin group received 5% albumin (10mlkg-1), whereas the NS group received NS (10 ml kg-1). Result: After 3h of treatment, both groups improved. However, the magnitude of improvement in the pH, BE and HCO3- levels were not different in comparisons between these two groups. In addition, there were no differences either in the body weight and weight gain 4 days after treatment or in the length of hospital stay. Conclusion: Albumin was not more effective than NS for initial hydration treatment of dehydrated term infants with metabolic acidosis due to acute diarrhea.

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