Albumin versus normal saline for dehydrated term infants with metabolic acidosis due to acute diarrhea

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5 Citations (Scopus)

Abstract

Objective: To compare the efficacy of albumin to normal saline (NS) for initial hydration therapy for dehydrated term infants with severe metabolic acidosis due to acute diarrhea. Study Design: We randomized 33 infants presenting with moderate-to-severe dehydration and metabolic acidosis (pH < 7.25 or base excess (BE) <-15) into two groups, an albumin group (n = 15) and a NS group (n = 18). For initial hydration treatment, the albumin group received 5% albumin (10mlkg-1), whereas the NS group received NS (10 ml kg-1). Result: After 3h of treatment, both groups improved. However, the magnitude of improvement in the pH, BE and HCO3- levels were not different in comparisons between these two groups. In addition, there were no differences either in the body weight and weight gain 4 days after treatment or in the length of hospital stay. Conclusion: Albumin was not more effective than NS for initial hydration treatment of dehydrated term infants with metabolic acidosis due to acute diarrhea.

Original languageEnglish
Pages (from-to)444-447
Number of pages4
JournalJournal of Perinatology
Volume29
Issue number6
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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