Alkoholkonsum und Risiko der rheumatoiden Arthritis: eine Mendel-Randomisierungsstudie

Translated title of the contribution: Alcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study

S. ‑.C. Bae, Young Ho Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To examine whether alcohol intake is causally associated with rheumatoid arthritis (RA). Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and a GWAS meta-analysis of 5539 autoantibody-positive RA patients and 20,169 controls as the outcome. Results: We selected 24 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables (IVs) to improve inference, 16 of which were inversely associated with RA. The IVW method showed no evidence of a causal association between alcohol intake and RA (beta = 0.218, SE = 0.213, p = 0.306). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (intercept = 0.027, p = 0.292). The MR-Egger analysis and the weighted median approach showed no causal association between alcohol intake and RA (beta = −0.778, SE = 0.947, p = 0.420 and beta = −0.286, SE = 0.302, p = 0.344, respectively). Cochran’s Q test did not indicate heterogeneity between IV estimates based on the individual variants, and results from a “leave-one-out” analysis demonstrated that no single SNP was driving the IVW point estimate. Conclusion: The MR analysis does not support a causal inverse association between alcohol intake and RA occurrence.

Original languageGerman
JournalZeitschrift fur Rheumatologie
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Random Allocation
Mendelian Randomization Analysis
Rheumatoid Arthritis
Alcohols
Nucleotides
Genome-Wide Association Study
Meta-Analysis
Genome

Keywords

  • Alcohol intake
  • Genetic predisposition to disease
  • Genome-wide association study
  • Mendelian randomization
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Alkoholkonsum und Risiko der rheumatoiden Arthritis : eine Mendel-Randomisierungsstudie. / Bae, S. ‑.C.; Lee, Young Ho.

In: Zeitschrift fur Rheumatologie, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Objective: To examine whether alcohol intake is causally associated with rheumatoid arthritis (RA). Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and a GWAS meta-analysis of 5539 autoantibody-positive RA patients and 20,169 controls as the outcome. Results: We selected 24 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables (IVs) to improve inference, 16 of which were inversely associated with RA. The IVW method showed no evidence of a causal association between alcohol intake and RA (beta = 0.218, SE = 0.213, p = 0.306). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (intercept = 0.027, p = 0.292). The MR-Egger analysis and the weighted median approach showed no causal association between alcohol intake and RA (beta = −0.778, SE = 0.947, p = 0.420 and beta = −0.286, SE = 0.302, p = 0.344, respectively). Cochran’s Q test did not indicate heterogeneity between IV estimates based on the individual variants, and results from a “leave-one-out” analysis demonstrated that no single SNP was driving the IVW point estimate. Conclusion: The MR analysis does not support a causal inverse association between alcohol intake and RA occurrence.",
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N2 - Objective: To examine whether alcohol intake is causally associated with rheumatoid arthritis (RA). Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and a GWAS meta-analysis of 5539 autoantibody-positive RA patients and 20,169 controls as the outcome. Results: We selected 24 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables (IVs) to improve inference, 16 of which were inversely associated with RA. The IVW method showed no evidence of a causal association between alcohol intake and RA (beta = 0.218, SE = 0.213, p = 0.306). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (intercept = 0.027, p = 0.292). The MR-Egger analysis and the weighted median approach showed no causal association between alcohol intake and RA (beta = −0.778, SE = 0.947, p = 0.420 and beta = −0.286, SE = 0.302, p = 0.344, respectively). Cochran’s Q test did not indicate heterogeneity between IV estimates based on the individual variants, and results from a “leave-one-out” analysis demonstrated that no single SNP was driving the IVW point estimate. Conclusion: The MR analysis does not support a causal inverse association between alcohol intake and RA occurrence.

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KW - Genome-wide association study

KW - Mendelian randomization

KW - Rheumatoid arthritis

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