Alkoholkonsum und Risiko der rheumatoiden Arthritis: eine Mendel-Randomisierungsstudie

Translated title of the contribution: Alcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study

S. ‑.C. Bae, Young Ho Lee

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To examine whether alcohol intake is causally associated with rheumatoid arthritis (RA). Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and a GWAS meta-analysis of 5539 autoantibody-positive RA patients and 20,169 controls as the outcome. Results: We selected 24 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables (IVs) to improve inference, 16 of which were inversely associated with RA. The IVW method showed no evidence of a causal association between alcohol intake and RA (beta = 0.218, SE = 0.213, p = 0.306). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (intercept = 0.027, p = 0.292). The MR-Egger analysis and the weighted median approach showed no causal association between alcohol intake and RA (beta = −0.778, SE = 0.947, p = 0.420 and beta = −0.286, SE = 0.302, p = 0.344, respectively). Cochran’s Q test did not indicate heterogeneity between IV estimates based on the individual variants, and results from a “leave-one-out” analysis demonstrated that no single SNP was driving the IVW point estimate. Conclusion: The MR analysis does not support a causal inverse association between alcohol intake and RA occurrence.

Translated title of the contributionAlcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study
Original languageGerman
JournalZeitschrift fur Rheumatologie
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Keywords

  • Alcohol intake
  • Genetic predisposition to disease
  • Genome-wide association study
  • Mendelian randomization
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Fingerprint Dive into the research topics of 'Alcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study'. Together they form a unique fingerprint.

  • Cite this