Alcohol intake and risk of systemic lupus erythematosus: a Mendelian randomization study

S. C. Bae, Young Ho Lee

Research output: Contribution to journalArticle

Abstract

Objectives: This study aimed to examine whether alcohol intake is causally associated with systemic lupus erythematosus (SLE). Methods: We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and an SLE GWAS consisting of 1311 SLE and 1783 control subjects of European descent as the outcome. Results: We selected 20 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables to improve inference. The IVW method found no evidence to support a causal association between alcohol intake and SLE (beta = –0.413, SE = 0.513, p = 0.421). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (intercept = 0.031, p = 0.582). The MR-Egger analysis found no causal association between alcohol intake and SLE (beta = –1.494, SE = 1.996, p = 0.464). Likewise, the weighted median approach also did not provide evidence of a causal association between alcohol intake and SLE (beta = –0.538, SE = 0.574, p = 0.349). The MR estimates determined using the IVW, weighted median, and MR-Egger regression methods were consistent and results from a “leave-one-out” analysis demonstrated that no single SNP was driving the IVW point estimate. Conclusions: The results of MR analysis do not support a causal inverse association between alcohol intake and SLE occurrence.

Original languageEnglish
Pages (from-to)174-180
Number of pages7
JournalLupus
Volume28
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1

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Random Allocation
Systemic Lupus Erythematosus
Mendelian Randomization Analysis
Alcohols
Genome-Wide Association Study
Single Nucleotide Polymorphism
Genome

Keywords

  • Alcohol intake
  • Mendelian randomization
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Alcohol intake and risk of systemic lupus erythematosus : a Mendelian randomization study. / Bae, S. C.; Lee, Young Ho.

In: Lupus, Vol. 28, No. 2, 01.02.2019, p. 174-180.

Research output: Contribution to journalArticle

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