Abstract
Aldosterone synthase gene (CYP11B2) -344C/T polymorphism has been reported to be associated with serum aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. The aim of this study was to evaluate the relation between CYP11B2 polymorphism and end-stage renal disease (ESRD) in the Korean population and the association with CYP11B2 polymorphism and cardiovascular morbidity in ESRD patients on hemodialysis. Genotyping was performed in 134 control subjects and 271 ESRD patients for CYP11B2 polymorphism using polymerase chain reaction through subsequent cleavage with restriction enzyme. Also current blood pressure, demographic, anthropometric and biochemical variables were investigated. The genotype distribution did not differ between ESRD patients and controls and there were no significant differences in blood pressure, use of antihypertensive medication, left ventricular hypertrophy and cardiovascular disease among the three genotypes in ESRD patients on hemodialysis. Our findings do not support the hypothesis that CYP11B2 polymorphism may be associated with prevalence of ESRD and suggest that CYP11B2 polymorphism may not be a genetic marker for cardiovascular morbidity in Korean ESRD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 67-72 |
| Number of pages | 6 |
| Journal | Electrolyte and Blood Pressure |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 Dec 1 |
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Keywords
- Aldosterone synthase
- Polymorphism, genetic
- Renal dialysis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Internal Medicine
- Physiology
Cite this
Aldosterone synthase gene (CYP11B2) polymorphism in Korean end-stage renal disease patients on hemodialysis. / Ji, Eun Lee; So, Yon Bae; Jeong-Yup, Kim; Heui, Jung Pyo; Kwon, Young-Joo.
In: Electrolyte and Blood Pressure, Vol. 7, No. 2, 01.12.2009, p. 67-72.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aldosterone synthase gene (CYP11B2) polymorphism in Korean end-stage renal disease patients on hemodialysis
AU - Ji, Eun Lee
AU - So, Yon Bae
AU - Jeong-Yup, Kim
AU - Heui, Jung Pyo
AU - Kwon, Young-Joo
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Aldosterone synthase gene (CYP11B2) -344C/T polymorphism has been reported to be associated with serum aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. The aim of this study was to evaluate the relation between CYP11B2 polymorphism and end-stage renal disease (ESRD) in the Korean population and the association with CYP11B2 polymorphism and cardiovascular morbidity in ESRD patients on hemodialysis. Genotyping was performed in 134 control subjects and 271 ESRD patients for CYP11B2 polymorphism using polymerase chain reaction through subsequent cleavage with restriction enzyme. Also current blood pressure, demographic, anthropometric and biochemical variables were investigated. The genotype distribution did not differ between ESRD patients and controls and there were no significant differences in blood pressure, use of antihypertensive medication, left ventricular hypertrophy and cardiovascular disease among the three genotypes in ESRD patients on hemodialysis. Our findings do not support the hypothesis that CYP11B2 polymorphism may be associated with prevalence of ESRD and suggest that CYP11B2 polymorphism may not be a genetic marker for cardiovascular morbidity in Korean ESRD patients.
AB - Aldosterone synthase gene (CYP11B2) -344C/T polymorphism has been reported to be associated with serum aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. The aim of this study was to evaluate the relation between CYP11B2 polymorphism and end-stage renal disease (ESRD) in the Korean population and the association with CYP11B2 polymorphism and cardiovascular morbidity in ESRD patients on hemodialysis. Genotyping was performed in 134 control subjects and 271 ESRD patients for CYP11B2 polymorphism using polymerase chain reaction through subsequent cleavage with restriction enzyme. Also current blood pressure, demographic, anthropometric and biochemical variables were investigated. The genotype distribution did not differ between ESRD patients and controls and there were no significant differences in blood pressure, use of antihypertensive medication, left ventricular hypertrophy and cardiovascular disease among the three genotypes in ESRD patients on hemodialysis. Our findings do not support the hypothesis that CYP11B2 polymorphism may be associated with prevalence of ESRD and suggest that CYP11B2 polymorphism may not be a genetic marker for cardiovascular morbidity in Korean ESRD patients.
KW - Aldosterone synthase
KW - Polymorphism, genetic
KW - Renal dialysis
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U2 - 10.5049/EBP.2009.7.2.67
DO - 10.5049/EBP.2009.7.2.67
M3 - Article
VL - 7
SP - 67
EP - 72
JO - Electrolyte and Blood Pressure
JF - Electrolyte and Blood Pressure
SN - 1738-5997
IS - 2
ER -