Alendronate-eluting biphasic calcium phosphate (BCP) scaffolds stimulate osteogenic differentiation

Sung Eun Kim, Young Pil Yun, Deok Won Lee, Eun Young Kang, Won Jae Jeong, Boram Lee, Myeong Seon Jeong, Hak Jun Kim, Kyeongsoon Park, Hae Ryong Song

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Biphasic calcium phosphate (BCP) scaffolds have been widely used in orthopedic and dental fields as osteoconductive bone substitutes. However, BCP scaffolds are not satisfactory for the stimulation of osteogenic differentiation and maturation. To enhance osteogenic differentiation, we prepared alendronate- (ALN-) eluting BCP scaffolds. The coating of ALN on BCP scaffolds was confirmed by scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR). An in vitro release study showed that release of ALN from ALN-eluting BCP scaffolds was sustained for up to 28 days. In vitro results revealed that MG-63 cells grown on ALN-eluting BCP scaffolds exhibited increased ALP activity and calcium deposition and upregulated gene expression of Runx2, ALP, OCN, and OPN compared with the BCP scaffold alone. Therefore, this study suggests that ALN-eluting BCP scaffolds have the potential to effectively stimulate osteogenic differentiation.

Original languageEnglish
Article number320713
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Alendronate
Scaffolds
X-Ray Emission Spectrometry
Bone Substitutes
Scanning electron microscopy
hydroxyapatite-beta tricalcium phosphate
Orthopedics
Fourier Transform Infrared Spectroscopy
Gene expression
Electron Scanning Microscopy
Energy dispersive spectroscopy
Tooth
Cells
Calcium
Gene Expression
Coatings

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Alendronate-eluting biphasic calcium phosphate (BCP) scaffolds stimulate osteogenic differentiation. / Kim, Sung Eun; Yun, Young Pil; Lee, Deok Won; Kang, Eun Young; Jeong, Won Jae; Lee, Boram; Jeong, Myeong Seon; Kim, Hak Jun; Park, Kyeongsoon; Song, Hae Ryong.

In: BioMed Research International, Vol. 2015, 320713, 2015.

Research output: Contribution to journalArticle

Kim, Sung Eun ; Yun, Young Pil ; Lee, Deok Won ; Kang, Eun Young ; Jeong, Won Jae ; Lee, Boram ; Jeong, Myeong Seon ; Kim, Hak Jun ; Park, Kyeongsoon ; Song, Hae Ryong. / Alendronate-eluting biphasic calcium phosphate (BCP) scaffolds stimulate osteogenic differentiation. In: BioMed Research International. 2015 ; Vol. 2015.
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AU - Jeong, Won Jae

AU - Lee, Boram

AU - Jeong, Myeong Seon

AU - Kim, Hak Jun

AU - Park, Kyeongsoon

AU - Song, Hae Ryong

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