All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping

Jung Min Lee; Dingchang Lin; Ha Reem Kim; Young Woo Pyo; Guosong Hong; Charles M. Lieber; Hong Gyu Park

doi:10.1021/acs.nanolett.1c00425

All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping

Jung Min Lee, Dingchang Lin, Ha Reem Kim, Young Woo Pyo, Guosong Hong, Charles M. Lieber, Hong Gyu Park

Department of Physics

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The development of a multifunctional device that achieves optogenetic neuromodulation and extracellular neural mapping is crucial for understanding neural circuits and treating brain disorders. Although various devices have been explored for this purpose, it is challenging to develop biocompatible optogenetic devices that can seamlessly interface with the brain. Herein, we present a tissue-like optoelectronic mesh with a compact interface that enables not only high spatial and temporal resolutions of optical stimulation but also the sampling of optically evoked neural activities. An in vitro experiment in hydrogel showed efficient light propagation through a freestanding SU-8 waveguide that was integrated with flexible mesh electronics. Additionally, an in vivo implantation of the tissue-like optoelectronic mesh in the brain of a live transgenic mouse enabled the sampling of optically evoked neural signals. Therefore, this multifunctional device can aid the chronic modulation of neural circuits and behavior studies for developing biological and therapeutic applications.

Original language	English
Pages (from-to)	3184-3190
Number of pages	7
Journal	Nano Letters
Volume	21
Issue number	7
DOIs	https://doi.org/10.1021/acs.nanolett.1c00425
Publication status	Published - 2021 Apr 14

Keywords

biocompatible optogenetic probes
chronic neural interface
flexible waveguide
injectable mesh electronics
optogenetics

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/acs.nanolett.1c00425

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title = "All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping",

abstract = "The development of a multifunctional device that achieves optogenetic neuromodulation and extracellular neural mapping is crucial for understanding neural circuits and treating brain disorders. Although various devices have been explored for this purpose, it is challenging to develop biocompatible optogenetic devices that can seamlessly interface with the brain. Herein, we present a tissue-like optoelectronic mesh with a compact interface that enables not only high spatial and temporal resolutions of optical stimulation but also the sampling of optically evoked neural activities. An in vitro experiment in hydrogel showed efficient light propagation through a freestanding SU-8 waveguide that was integrated with flexible mesh electronics. Additionally, an in vivo implantation of the tissue-like optoelectronic mesh in the brain of a live transgenic mouse enabled the sampling of optically evoked neural signals. Therefore, this multifunctional device can aid the chronic modulation of neural circuits and behavior studies for developing biological and therapeutic applications.",

keywords = "biocompatible optogenetic probes, chronic neural interface, flexible waveguide, injectable mesh electronics, optogenetics",

author = "Lee, {Jung Min} and Dingchang Lin and Kim, {Ha Reem} and Pyo, {Young Woo} and Guosong Hong and Lieber, {Charles M.} and Park, {Hong Gyu}",

note = "Funding Information: H.-G.P. acknowledges the support from the Samsung Research Funding and Incubation Center of Samsung Electronics (SRFC-MA2001-01) and IBS-R023-D1. G.H. acknowledges the support from the Wu Tsai Neurosciences Institute of Stanford University. C.M.L. acknowledges partial support of this work by the Air Force Office of Scientific Research (FA9550-14-1-0136). Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

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doi = "10.1021/acs.nanolett.1c00425",

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AU - Lee, Jung Min

AU - Lin, Dingchang

AU - Kim, Ha Reem

AU - Pyo, Young Woo

AU - Hong, Guosong

AU - Lieber, Charles M.

AU - Park, Hong Gyu

N1 - Funding Information: H.-G.P. acknowledges the support from the Samsung Research Funding and Incubation Center of Samsung Electronics (SRFC-MA2001-01) and IBS-R023-D1. G.H. acknowledges the support from the Wu Tsai Neurosciences Institute of Stanford University. C.M.L. acknowledges partial support of this work by the Air Force Office of Scientific Research (FA9550-14-1-0136). Publisher Copyright: © 2021 American Chemical Society.

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N2 - The development of a multifunctional device that achieves optogenetic neuromodulation and extracellular neural mapping is crucial for understanding neural circuits and treating brain disorders. Although various devices have been explored for this purpose, it is challenging to develop biocompatible optogenetic devices that can seamlessly interface with the brain. Herein, we present a tissue-like optoelectronic mesh with a compact interface that enables not only high spatial and temporal resolutions of optical stimulation but also the sampling of optically evoked neural activities. An in vitro experiment in hydrogel showed efficient light propagation through a freestanding SU-8 waveguide that was integrated with flexible mesh electronics. Additionally, an in vivo implantation of the tissue-like optoelectronic mesh in the brain of a live transgenic mouse enabled the sampling of optically evoked neural signals. Therefore, this multifunctional device can aid the chronic modulation of neural circuits and behavior studies for developing biological and therapeutic applications.

AB - The development of a multifunctional device that achieves optogenetic neuromodulation and extracellular neural mapping is crucial for understanding neural circuits and treating brain disorders. Although various devices have been explored for this purpose, it is challenging to develop biocompatible optogenetic devices that can seamlessly interface with the brain. Herein, we present a tissue-like optoelectronic mesh with a compact interface that enables not only high spatial and temporal resolutions of optical stimulation but also the sampling of optically evoked neural activities. An in vitro experiment in hydrogel showed efficient light propagation through a freestanding SU-8 waveguide that was integrated with flexible mesh electronics. Additionally, an in vivo implantation of the tissue-like optoelectronic mesh in the brain of a live transgenic mouse enabled the sampling of optically evoked neural signals. Therefore, this multifunctional device can aid the chronic modulation of neural circuits and behavior studies for developing biological and therapeutic applications.

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All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping

Abstract

Keywords

ASJC Scopus subject areas

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