Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population

Heon-Jeong Lee, Hong Seock Lee, Yong Ku Kim, Seung Hyun Kim, Leen Kim, Min-Soo Lee, Sook Haeng Joe, In Kwa Jung, Kwang Yoon Suh, Sangduk Kim

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39 Citations (Scopus)


Polymorphism in exon III of the dopamine D4 receptor (DRD4) gene has been implicated to be associated with the human personality trait of novelty seeking (NS). For this study, we have investigated the possible association between 48-bp VNTR in exon III and -521 C/T SNP of the DRD4 and personality traits among young (≈14 years of age) Korean female population. We found that the interaction between the two alleles of DRD4 polymorphism, 48-bp VNTR and -521 C/T, were significantly high on NS (F = 4.88, P = 0.029) and persistence (P) (F = 5.05, P = 0.027) personality scores, suggesting that the variants of DRD4 gene influence the NS and P (persistent) personality traits. When analyzed independently, however, the two different alleles of DRD4 polymorphisms, 48-bp VNTR and - 521 C/T, there was no direct correlation with the personality traits.

Original languageEnglish
Pages (from-to)76-80
Number of pages5
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume118 B
Issue number1
Publication statusPublished - 2003 Apr 1



  • DRD4
  • Novelty seeking
  • Persistence
  • Polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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