Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings

Ji Ung Park, Jiyeon Ham, Sukwha Kim, Ji-Hun Seo, Sang Hyon Kim, Seonju Lee, Hye Jeong Min, Sunghyun Choi, Ra Mi Choi, Heejin Kim, Sohee Oh, Ji An Hur, Tae Hyun Choi, Yan Lee

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture - an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in α-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation-related cells, myeloperoxidase and transforming growth factor-β resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications.

Original languageEnglish
Pages (from-to)4217-4225
Number of pages9
JournalActa Biomaterialia
Volume10
Issue number10
DOIs
Publication statusPublished - 2014 Oct 1
Externally publishedYes

Fingerprint

Silicones
Rats
Coatings
Contracture
Collagen
Capsules
Inflammation
Foreign-Body Reaction
Mammaplasty
Transforming Growth Factors
Biocompatible Materials
Fibroblasts
Biocompatibility
Biomaterials
Surgery
Peroxidase
Adsorption
Smooth Muscle
Muscle
Actins

Keywords

  • Capsular contracture
  • Foreign body reaction
  • Phosphorylcholine
  • Silicone
  • Surface modification

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings. / Park, Ji Ung; Ham, Jiyeon; Kim, Sukwha; Seo, Ji-Hun; Kim, Sang Hyon; Lee, Seonju; Min, Hye Jeong; Choi, Sunghyun; Choi, Ra Mi; Kim, Heejin; Oh, Sohee; Hur, Ji An; Choi, Tae Hyun; Lee, Yan.

In: Acta Biomaterialia, Vol. 10, No. 10, 01.10.2014, p. 4217-4225.

Research output: Contribution to journalArticle

Park, JU, Ham, J, Kim, S, Seo, J-H, Kim, SH, Lee, S, Min, HJ, Choi, S, Choi, RM, Kim, H, Oh, S, Hur, JA, Choi, TH & Lee, Y 2014, 'Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings', Acta Biomaterialia, vol. 10, no. 10, pp. 4217-4225. https://doi.org/10.1016/j.actbio.2014.07.007
Park, Ji Ung ; Ham, Jiyeon ; Kim, Sukwha ; Seo, Ji-Hun ; Kim, Sang Hyon ; Lee, Seonju ; Min, Hye Jeong ; Choi, Sunghyun ; Choi, Ra Mi ; Kim, Heejin ; Oh, Sohee ; Hur, Ji An ; Choi, Tae Hyun ; Lee, Yan. / Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings. In: Acta Biomaterialia. 2014 ; Vol. 10, No. 10. pp. 4217-4225.
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