Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings

Ji Ung Park, Jiyeon Ham, Sukwha Kim, Ji-Hun Seo, Sang Hyon Kim, Seonju Lee, Hye Jeong Min, Sunghyun Choi, Ra Mi Choi, Heejin Kim, Sohee Oh, Ji An Hur, Tae Hyun Choi, Yan Lee

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17 Citations (Scopus)


Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture - an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in α-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation-related cells, myeloperoxidase and transforming growth factor-β resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications.

Original languageEnglish
Pages (from-to)4217-4225
Number of pages9
JournalActa Biomaterialia
Issue number10
Publication statusPublished - 2014 Oct 1
Externally publishedYes



  • Capsular contracture
  • Foreign body reaction
  • Phosphorylcholine
  • Silicone
  • Surface modification

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Park, J. U., Ham, J., Kim, S., Seo, J-H., Kim, S. H., Lee, S., Min, H. J., Choi, S., Choi, R. M., Kim, H., Oh, S., Hur, J. A., Choi, T. H., & Lee, Y. (2014). Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings. Acta Biomaterialia, 10(10), 4217-4225.