Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia

Hawk Kim, Kyoo Hyung Lee, Sung Soo Yoon, Sang Kyun Sohn, Young Don Joo, Sung Hyun Kim, Byung Soo Kim, Jung Hye Choi, Jae Youg Kwak, Myung Soo Hyun, Sung Hwa Bae, Ho Jin Shin, Jong Ho Won, Sukjoong Oh, Won Sik Lee, Jae Hoo Park, Chul Won Jung

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14 Citations (Scopus)

Abstract

Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age. We retrospectively analyzed the impact of older age on transplantation outcomes and survival in a total of 225 adult patients with AA who underwent allo-HSCT: 57 patients >40 years old (older patient group [OPG]) and 168 patients ≤40 years old (younger patient group [YPG]). Age at allo-HSCT ≤40 years, time from diagnosis to allo-HSCT ≤6 months, and matched related donor (MRD) were favorable prognostic factors in all study patients. Risk analysis of survival in the OPG showed that age >50 years was the only poor prognostic factor. Survival did not differ significantly between the YPG and patients <50 years old in the OPG. In conclusion, patients between the ages of 41 and 50 years with severe AA and MRDs should undergo allo-HSCT as early as possible to optimize survival.

Original languageEnglish
Pages (from-to)1500-1508
Number of pages9
JournalBiology of Blood and Marrow Transplantation
Volume18
Issue number10
DOIs
Publication statusPublished - 2012 Oct 1

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Aplastic anemia
  • Elderly

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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    Kim, H., Lee, K. H., Yoon, S. S., Sohn, S. K., Joo, Y. D., Kim, S. H., Kim, B. S., Choi, J. H., Kwak, J. Y., Hyun, M. S., Bae, S. H., Shin, H. J., Won, J. H., Oh, S., Lee, W. S., Park, J. H., & Jung, C. W. (2012). Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia. Biology of Blood and Marrow Transplantation, 18(10), 1500-1508. https://doi.org/10.1016/j.bbmt.2012.03.015