Allosteric regulation of phosphate diester transesterification based upon a dinuclear zinc catalyst assembled via the weak-link approach

Jae Yoon Hyo, Jungseok Heo, Chad A. Mirkin

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The design and synthesis of a novel supramolecular allosteric catalyst, assembled via the weak-link approach, is presented. The catalyst shows completely reversible allosteric regulation for the catalytic cleavage of 2-(hydroxypropyl)-p-nitrophenyl phosphate (HPNP), which is an RNA model substrate. The system works under pseudo-aqueous conditions and can be turned completely off due to a bridging acetate ligand in the deactivated state, which inhibits the analogous intermolecular catalytic process.

Original languageEnglish
Pages (from-to)14182-14183
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number46
DOIs
Publication statusPublished - 2007 Nov 21
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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