Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction

Ju Yeon Park, Sang Hak Lee, Min-Jeong Shin, Geum Sook Hwang

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood.We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls. Lysophosphatidylcholine (lysoPC) and lysophosphatidylethanolamine (lysoPE) species containing unsaturated fatty acids and free fatty acids were associated with an increased risk of CAD, whereas species of lysoPC and lyso-alkyl PC containing saturated fatty acids were associated with a decreased risk. Additionally, PC species containing palmitic acid, diacylglycerol, sphingomyelin, and ceramide were associated with an increased risk of MI, whereas PEplasmalogen and phosphatidylinositol species were associated with a decreased risk. In MI patients, we found strong positive correlation between lipid metabolites related to the sphingolipid pathway, sphingomyelin, and ceramide and acute inflammatory markers (high-sensitivity C-reactive protein). The results of this study demonstrate altered signatures in lipid metabolism in patients with angina or MI. Lipidomic profiling could provide the information to identity the specific lipid metabolites under the presence of disturbed metabolic pathways in patients with CAD.

Original languageEnglish
Article numbere0135228
JournalPLoS One
Volume10
Issue number8
DOIs
Publication statusPublished - 2015 Aug 10

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myocardial infarction
Angina Pectoris
Lipid Metabolism
lipid metabolism
Myocardial Infarction
Metabolites
Lipids
Coronary Artery Disease
lipids
Lysophosphatidylcholines
metabolites
Sphingomyelins
Ceramides
lysophosphatidylcholine
sphingomyelins
ceramides
risk reduction
multivariate analysis
Multivariate Analysis
Sphingolipids

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction. / Park, Ju Yeon; Lee, Sang Hak; Shin, Min-Jeong; Hwang, Geum Sook.

In: PLoS One, Vol. 10, No. 8, e0135228, 10.08.2015.

Research output: Contribution to journalArticle

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