Alteration of CD4+CD25+Foxp3+ T cell level in Kawasaki disease

Su Ye Sohn, Young Wooh Song, Yun Ku Yeo, Kyung Kim, Giyoung Jang, Chan Wook Woo, Jung Hwa Lee, Kwang Chul Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: Exaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD. We investigated the profiles of T regulatory cells and their correlation with the clinical course of KD. Methods: Peripheral blood mononuclear cells were collected from 17 KD patients during acute febrile and subacute afebrile phases. T cells expressing CD4, CD25, and Foxp3 were analyzed using flow cytometry, and the results were correlated with the clinical course of KD. Results: The percentage of circulating CD4+CD25highFoxp3+ T cells among CD4+ T cells was significantly higher during the subacute afebrile phase than during the acute febrile phase (1.10%±1.22% vs. 0.55%±0.53%, P=0.049). Although levels of CD4+CD25lowFoxp3+ T cells and CD4+CD25. +Foxp3+ T cells were only slightly altered, the percentage of CD4+CD25-Foxp3+ T cells among CD4+ T cells was significantly lower during the subacute afebrile phase than during the acute febrile phase (2.96%±1.95% vs. 5.64%±5.69%, P=0.036). Consequently, the ratio of CD25highFoxp3+ T cells to CD25+Foxp3+ T cells was higher during the subacute afebrile phase than during the acute febrile phase (0.45%±0.57% vs. 0.13%±0.13%, P=0.038). Conclusion: Decreased CD4+CD25highFoxp3+ T cells and/or an imbalanced ratio of CD4+CD25highFoxp3+ T cells to CD4+CD25+ Foxp3+ T cells might play a role in KD development. Considering that all KD patients were treated with intravenous immunoglobulin (IVIG), recovery of CD4+CD25highFoxp3+ T cells during the subacute afebrile phase could be a mechanism of IVIG.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalKorean Journal of Pediatrics
Volume54
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1

Keywords

  • Kawasaki disease
  • Regulatory T cell

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

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