Alteration of red blood cell aggregation during blood storage

Hyun Jung Lim, Jeong Hun Nam, Byoung Kwon Lee, Jang Soo Suh, Sehyun Shin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Even though the trade-off between the benefits and risks of blood transfusion has been discussed for the last several decades, it requires further understanding of the rheological changes in stored blood that include the alteration of red blood cell (RBC) aggregation. The RBC aggregation of stored blood in its autologous plasma was monitored through the storage period (35 days). The critical shear stress, as a measure of RBC aggregation, was determined by using a microfluidic aggregometer. Blood was processed into a blood bag containing the anticoagulant CPDA1 and stored at 4°C. It was subjected to assays after zero, seven, 14, and 35 days. The critical shear stress for stored blood did not change up to 14 days of storage but exhibited a significant decrease after 35 days of storage. These results were identical to those of the conventional aggregation index (AI). Also, in the alteration of RBC aggregation for blood storage, the effect of the plasma factor was slightly stronger than that of the cellular factor. Through the present study, the critical shear stress as a new measure of RBC aggregation may help to monitor and control the quality of blood storage.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalKorea Australia Rheology Journal
Volume23
Issue number2
DOIs
Publication statusPublished - 2011 Jun 1

Fingerprint

erythrocytes
blood
Blood
Agglomeration
Cells
critical loading
shear stress
Shear stress
anticoagulants
transfusion
bags
Plasmas
Microfluidics
Anticoagulants
Assays

Keywords

  • Aggregation
  • Blood
  • Critical shear stress
  • RBC
  • Storage

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Materials Science(all)

Cite this

Alteration of red blood cell aggregation during blood storage. / Lim, Hyun Jung; Nam, Jeong Hun; Lee, Byoung Kwon; Suh, Jang Soo; Shin, Sehyun.

In: Korea Australia Rheology Journal, Vol. 23, No. 2, 01.06.2011, p. 67-70.

Research output: Contribution to journalArticle

Lim, Hyun Jung ; Nam, Jeong Hun ; Lee, Byoung Kwon ; Suh, Jang Soo ; Shin, Sehyun. / Alteration of red blood cell aggregation during blood storage. In: Korea Australia Rheology Journal. 2011 ; Vol. 23, No. 2. pp. 67-70.
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