Alterations in arterial function after high-voltage electrical injury

Kyoung Ha Park, Woo J. Park, Min Kyu Kim, Hyun Sook Kim, Seong Hwan Kim, Goo Yeong Cho, Young Jin Choi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: The aim of this study was to evaluate the functional changes of the arterial endothelium and smooth muscle after a high-voltage electrical injury (HVEI), using flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD).Methods: Twenty-five male patients injured in the upper extremities by current due to contact with more than 20,000 volts were enrolled in the study. FMD and NMD were measured on the brachial artery within 48 hours after HVEI, and follow-up FMD and NMD were evaluated six weeks later. In addition, we enrolled an age, sex and body mass index matched healthy control group consisting of 25 individuals. Including FMD and NMD, all the variables of the control group were investigated one time and compared with the initial and six week follow-up data of the HVEI group.Results: A significantly lower initial FMD was seen in the HVEI group compared with the control group (2.1 ± 1.2% versus 13.6 ± 3.4%, P < 0.01). At the six week follow-up, the FMD of the HVEI group had significantly improved compared to the initial FMD (2.1 ± 1.2% versus 5.1 ± 2.1%, P < 0.01), but it was still lower than the FMD of the control group (5.1 ± 2.1% versus 13.6 ± 3.4%, P < 0.01). A significantly lower NMD was seen both initially and at the six week follow-up compared with the NMD of the control group (7.3 ± 4.7% versus 20.4 ± 4.1%, P < 0.01 and 11.4 ± 6.7% versus 20.4 ± 4.1%, P < 0.01, respectively). The FMD study of the contralateral arm which was uninjured by HVEI was available in six patients. In those patients, the six week follow-up FMD was significantly improved in the HVEI arm compared with the initial FMD (1.8 ± 0.6% versus 4.4 ± 1.6%, P < 0.01). However, in the contralateral uninjured arm, there was no difference between the initial and the six week follow-up FMDs (5.5 ± 1.4% versus 6.9 ± 2.2%, P = 0.26).Conclusions: After HVEI, the endothelial and smooth muscle functions of the brachial artery were significantly decreased for at least six weeks. Long term cautious care might be needed for all victims of HVEI, because there is a chance of increased risk of thrombosis or stenosis in the injured arm.

Original languageEnglish
Article numberR25
JournalCritical Care
Volume16
Issue number1
DOIs
Publication statusPublished - 2012 Feb 12

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Dilatation
Wounds and Injuries
Nitrates
Control Groups
Brachial Artery
Smooth Muscle
Arm Injuries
Long-Term Care
Upper Extremity
Endothelium
Pathologic Constriction
Body Mass Index
Thrombosis
Arm

Keywords

  • Arterial function
  • Endothelium
  • Flow-mediated dilation
  • High-voltage electrical injury
  • Nitrate-mediated dilation
  • Smooth muscle

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Park, K. H., Park, W. J., Kim, M. K., Kim, H. S., Kim, S. H., Cho, G. Y., & Choi, Y. J. (2012). Alterations in arterial function after high-voltage electrical injury. Critical Care, 16(1), [R25]. https://doi.org/10.1186/cc11190

Alterations in arterial function after high-voltage electrical injury. / Park, Kyoung Ha; Park, Woo J.; Kim, Min Kyu; Kim, Hyun Sook; Kim, Seong Hwan; Cho, Goo Yeong; Choi, Young Jin.

In: Critical Care, Vol. 16, No. 1, R25, 12.02.2012.

Research output: Contribution to journalArticle

Park, KH, Park, WJ, Kim, MK, Kim, HS, Kim, SH, Cho, GY & Choi, YJ 2012, 'Alterations in arterial function after high-voltage electrical injury', Critical Care, vol. 16, no. 1, R25. https://doi.org/10.1186/cc11190
Park, Kyoung Ha ; Park, Woo J. ; Kim, Min Kyu ; Kim, Hyun Sook ; Kim, Seong Hwan ; Cho, Goo Yeong ; Choi, Young Jin. / Alterations in arterial function after high-voltage electrical injury. In: Critical Care. 2012 ; Vol. 16, No. 1.
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abstract = "Introduction: The aim of this study was to evaluate the functional changes of the arterial endothelium and smooth muscle after a high-voltage electrical injury (HVEI), using flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD).Methods: Twenty-five male patients injured in the upper extremities by current due to contact with more than 20,000 volts were enrolled in the study. FMD and NMD were measured on the brachial artery within 48 hours after HVEI, and follow-up FMD and NMD were evaluated six weeks later. In addition, we enrolled an age, sex and body mass index matched healthy control group consisting of 25 individuals. Including FMD and NMD, all the variables of the control group were investigated one time and compared with the initial and six week follow-up data of the HVEI group.Results: A significantly lower initial FMD was seen in the HVEI group compared with the control group (2.1 ± 1.2{\%} versus 13.6 ± 3.4{\%}, P < 0.01). At the six week follow-up, the FMD of the HVEI group had significantly improved compared to the initial FMD (2.1 ± 1.2{\%} versus 5.1 ± 2.1{\%}, P < 0.01), but it was still lower than the FMD of the control group (5.1 ± 2.1{\%} versus 13.6 ± 3.4{\%}, P < 0.01). A significantly lower NMD was seen both initially and at the six week follow-up compared with the NMD of the control group (7.3 ± 4.7{\%} versus 20.4 ± 4.1{\%}, P < 0.01 and 11.4 ± 6.7{\%} versus 20.4 ± 4.1{\%}, P < 0.01, respectively). The FMD study of the contralateral arm which was uninjured by HVEI was available in six patients. In those patients, the six week follow-up FMD was significantly improved in the HVEI arm compared with the initial FMD (1.8 ± 0.6{\%} versus 4.4 ± 1.6{\%}, P < 0.01). However, in the contralateral uninjured arm, there was no difference between the initial and the six week follow-up FMDs (5.5 ± 1.4{\%} versus 6.9 ± 2.2{\%}, P = 0.26).Conclusions: After HVEI, the endothelial and smooth muscle functions of the brachial artery were significantly decreased for at least six weeks. Long term cautious care might be needed for all victims of HVEI, because there is a chance of increased risk of thrombosis or stenosis in the injured arm.",
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AU - Park, Kyoung Ha

AU - Park, Woo J.

AU - Kim, Min Kyu

AU - Kim, Hyun Sook

AU - Kim, Seong Hwan

AU - Cho, Goo Yeong

AU - Choi, Young Jin

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N2 - Introduction: The aim of this study was to evaluate the functional changes of the arterial endothelium and smooth muscle after a high-voltage electrical injury (HVEI), using flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD).Methods: Twenty-five male patients injured in the upper extremities by current due to contact with more than 20,000 volts were enrolled in the study. FMD and NMD were measured on the brachial artery within 48 hours after HVEI, and follow-up FMD and NMD were evaluated six weeks later. In addition, we enrolled an age, sex and body mass index matched healthy control group consisting of 25 individuals. Including FMD and NMD, all the variables of the control group were investigated one time and compared with the initial and six week follow-up data of the HVEI group.Results: A significantly lower initial FMD was seen in the HVEI group compared with the control group (2.1 ± 1.2% versus 13.6 ± 3.4%, P < 0.01). At the six week follow-up, the FMD of the HVEI group had significantly improved compared to the initial FMD (2.1 ± 1.2% versus 5.1 ± 2.1%, P < 0.01), but it was still lower than the FMD of the control group (5.1 ± 2.1% versus 13.6 ± 3.4%, P < 0.01). A significantly lower NMD was seen both initially and at the six week follow-up compared with the NMD of the control group (7.3 ± 4.7% versus 20.4 ± 4.1%, P < 0.01 and 11.4 ± 6.7% versus 20.4 ± 4.1%, P < 0.01, respectively). The FMD study of the contralateral arm which was uninjured by HVEI was available in six patients. In those patients, the six week follow-up FMD was significantly improved in the HVEI arm compared with the initial FMD (1.8 ± 0.6% versus 4.4 ± 1.6%, P < 0.01). However, in the contralateral uninjured arm, there was no difference between the initial and the six week follow-up FMDs (5.5 ± 1.4% versus 6.9 ± 2.2%, P = 0.26).Conclusions: After HVEI, the endothelial and smooth muscle functions of the brachial artery were significantly decreased for at least six weeks. Long term cautious care might be needed for all victims of HVEI, because there is a chance of increased risk of thrombosis or stenosis in the injured arm.

AB - Introduction: The aim of this study was to evaluate the functional changes of the arterial endothelium and smooth muscle after a high-voltage electrical injury (HVEI), using flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD).Methods: Twenty-five male patients injured in the upper extremities by current due to contact with more than 20,000 volts were enrolled in the study. FMD and NMD were measured on the brachial artery within 48 hours after HVEI, and follow-up FMD and NMD were evaluated six weeks later. In addition, we enrolled an age, sex and body mass index matched healthy control group consisting of 25 individuals. Including FMD and NMD, all the variables of the control group were investigated one time and compared with the initial and six week follow-up data of the HVEI group.Results: A significantly lower initial FMD was seen in the HVEI group compared with the control group (2.1 ± 1.2% versus 13.6 ± 3.4%, P < 0.01). At the six week follow-up, the FMD of the HVEI group had significantly improved compared to the initial FMD (2.1 ± 1.2% versus 5.1 ± 2.1%, P < 0.01), but it was still lower than the FMD of the control group (5.1 ± 2.1% versus 13.6 ± 3.4%, P < 0.01). A significantly lower NMD was seen both initially and at the six week follow-up compared with the NMD of the control group (7.3 ± 4.7% versus 20.4 ± 4.1%, P < 0.01 and 11.4 ± 6.7% versus 20.4 ± 4.1%, P < 0.01, respectively). The FMD study of the contralateral arm which was uninjured by HVEI was available in six patients. In those patients, the six week follow-up FMD was significantly improved in the HVEI arm compared with the initial FMD (1.8 ± 0.6% versus 4.4 ± 1.6%, P < 0.01). However, in the contralateral uninjured arm, there was no difference between the initial and the six week follow-up FMDs (5.5 ± 1.4% versus 6.9 ± 2.2%, P = 0.26).Conclusions: After HVEI, the endothelial and smooth muscle functions of the brachial artery were significantly decreased for at least six weeks. Long term cautious care might be needed for all victims of HVEI, because there is a chance of increased risk of thrombosis or stenosis in the injured arm.

KW - Arterial function

KW - Endothelium

KW - Flow-mediated dilation

KW - High-voltage electrical injury

KW - Nitrate-mediated dilation

KW - Smooth muscle

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