Altered expression of Notch1 in Alzheimer’s disease

Sun Jung Cho, Sang Moon Yun, Chulman Jo, Jihyun Jeong, Moon Ho Park, Changsu Han, Young Ho Koh

Research output: Contribution to journalArticle

Abstract

Notch signaling is an evolutionarily conserved pathway that regulates cell-cell interactions through binding of Notch family receptors to their cognate ligands. Notch signaling has an essential role in vascular development and angiogenesis. Recent studies have reported that Notch may be implicated in Alzheimer’s disease (AD) pathophysiology. We measured the levels of soluble Notch1 (sNotch1) in the plasma samples from 72 dementia patients (average age 75.1 y), 89 subjects with amnestic mild cognitive impairment (MCI) (average age 73.72 y), and 150 cognitively normal controls (average age 72.34 y). Plasma levels of sNotch1 were 25.27% lower in dementia patients as compared to healthy control subjects. However, the level of Notch1 protein was significantly increased in human brain microvascular endothelial cells (HBMECs) after amyloid-beta treatment. Also, Notch1 mRNA level was significantly increased in HBMECs and iPSC-derived neuronal cells from AD patient compared to normal control. These results indicate that altered expression of Notch1 might be associated with the risk of Alzheimer’s disease.

Original languageEnglish
Article numbere0224941
JournalPloS one
Volume14
Issue number11
DOIs
Publication statusPublished - 2019 Jan 1

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Cho, S. J., Yun, S. M., Jo, C., Jeong, J., Park, M. H., Han, C., & Koh, Y. H. (2019). Altered expression of Notch1 in Alzheimer’s disease. PloS one, 14(11), [e0224941]. https://doi.org/10.1371/journal.pone.0224941