Abstract
The sodium/iodide symporter (NIS) is a membrane glycoprotein that mediates active I uptake during the treatment of cancer of the thyroid gland and extrathyroidal tissues. NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers. To investigate the pattern of NIS gene expression and provide evidence of its beneficial effects in human anaplastic cancer ARO cells by using a radioactive complementary DNA (cDNA) microarray.
| Original language | English |
|---|---|
| Pages (from-to) | 1155-1162 |
| Number of pages | 8 |
| Journal | Nuclear Medicine Communications |
| Volume | 26 |
| Issue number | 12 |
| Publication status | Published - 2005 |
Fingerprint
Keywords
- CDNA microarray
- Human anaplastic cancer ARO cells
- PTP family
- Ras oncogene family
- Sodium/iodide symporter (NIS)
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Choe, J-G., Kim, Y. R., Kim, K. N., Choo, H. J., Shin, J. H., Lee, Y. J., Chung, J. K., & Kim, M-K. (2005). Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray. Nuclear Medicine Communications, 26(12), 1155-1162.