Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray

Jae Gol Choe, Yu Ri Kim, Ki Nam Kim, Hyo Jung Choo, Jae Hoon Shin, Yong Jin Lee, June Key Chung, Meyoung Kon Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The sodium/iodide symporter (NIS) is a membrane glycoprotein that mediates active I uptake during the treatment of cancer of the thyroid gland and extrathyroidal tissues. NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers. To investigate the pattern of NIS gene expression and provide evidence of its beneficial effects in human anaplastic cancer ARO cells by using a radioactive complementary DNA (cDNA) microarray.

Original languageEnglish
Pages (from-to)1155-1162
Number of pages8
JournalNuclear Medicine Communications
Volume26
Issue number12
DOIs
Publication statusPublished - 2005 Dec

Keywords

  • CDNA microarray
  • Human anaplastic cancer ARO cells
  • PTP family
  • Ras oncogene family
  • Sodium/iodide symporter (NIS)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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