The sodium/iodide symporter (NIS) is a membrane glycoprotein that mediates active I uptake during the treatment of cancer of the thyroid gland and extrathyroidal tissues. NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers. To investigate the pattern of NIS gene expression and provide evidence of its beneficial effects in human anaplastic cancer ARO cells by using a radioactive complementary DNA (cDNA) microarray.
- CDNA microarray
- Human anaplastic cancer ARO cells
- PTP family
- Ras oncogene family
- Sodium/iodide symporter (NIS)
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging