Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray

Jae Gol Choe; Yu Ri Kim; Ki Nam Kim; Hyo Jung Choo; Jae Hoon Shin; Yong Jin Lee; June Key Chung; Meyoung Kon Kim

doi:10.1097/00006231-200512000-00017

Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray

Jae Gol Choe, Yu Ri Kim, Ki Nam Kim, Hyo Jung Choo, Jae Hoon Shin, Yong Jin Lee, June Key Chung, Meyoung Kon Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The sodium/iodide symporter (NIS) is a membrane glycoprotein that mediates active I uptake during the treatment of cancer of the thyroid gland and extrathyroidal tissues. NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers. To investigate the pattern of NIS gene expression and provide evidence of its beneficial effects in human anaplastic cancer ARO cells by using a radioactive complementary DNA (cDNA) microarray.

Original language	English
Pages (from-to)	1155-1162
Number of pages	8
Journal	Nuclear Medicine Communications
Volume	26
Issue number	12
DOIs	https://doi.org/10.1097/00006231-200512000-00017
Publication status	Published - 2005 Dec

Keywords

CDNA microarray
Human anaplastic cancer ARO cells
PTP family
Ras oncogene family
Sodium/iodide symporter (NIS)

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1097/00006231-200512000-00017

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Gol Choe, J., Kim, Y. R., Kim, K. N., Choo, H. J., Shin, J. H., Lee, Y. J., Chung, J. K., & Kim, M. K. (2005). Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray. Nuclear Medicine Communications, 26(12), 1155-1162. https://doi.org/10.1097/00006231-200512000-00017

Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray. / Gol Choe, Jae; Kim, Yu Ri; Kim, Ki Nam; Choo, Hyo Jung; Shin, Jae Hoon; Lee, Yong Jin; Chung, June Key; Kim, Meyoung Kon.

In: Nuclear Medicine Communications, Vol. 26, No. 12, 12.2005, p. 1155-1162.

Research output: Contribution to journal › Article › peer-review

Gol Choe, J, Kim, YR, Kim, KN, Choo, HJ, Shin, JH, Lee, YJ, Chung, JK & Kim, MK 2005, 'Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray', Nuclear Medicine Communications, vol. 26, no. 12, pp. 1155-1162. https://doi.org/10.1097/00006231-200512000-00017

Gol Choe, Jae ; Kim, Yu Ri ; Kim, Ki Nam ; Choo, Hyo Jung ; Shin, Jae Hoon ; Lee, Yong Jin ; Chung, June Key ; Kim, Meyoung Kon. / Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray. In: Nuclear Medicine Communications. 2005 ; Vol. 26, No. 12. pp. 1155-1162.

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abstract = "The sodium/iodide symporter (NIS) is a membrane glycoprotein that mediates active I uptake during the treatment of cancer of the thyroid gland and extrathyroidal tissues. NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers. To investigate the pattern of NIS gene expression and provide evidence of its beneficial effects in human anaplastic cancer ARO cells by using a radioactive complementary DNA (cDNA) microarray.",

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