Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray

Jae-Gol Choe, Yu Ri Kim, Ki Nam Kim, Hyo Jung Choo, Jae Hoon Shin, Yong Jin Lee, June Key Chung, Meyoung-Kon Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The sodium/iodide symporter (NIS) is a membrane glycoprotein that mediates active I uptake during the treatment of cancer of the thyroid gland and extrathyroidal tissues. NIS gene transfection, a gene-therapy modality, has been introduced in many types of cancer, such as prostate cancer and breast cancer, and has demonstrated a high potential for the treatment of non-thyroidal cancers. To investigate the pattern of NIS gene expression and provide evidence of its beneficial effects in human anaplastic cancer ARO cells by using a radioactive complementary DNA (cDNA) microarray.

Original languageEnglish
Pages (from-to)1155-1162
Number of pages8
JournalNuclear Medicine Communications
Volume26
Issue number12
Publication statusPublished - 2005

Fingerprint

Transcriptome
Transfection
Cell Line
Breast Neoplasms
Genes
Neoplasms
Membrane Glycoproteins
Oligonucleotide Array Sequence Analysis
Thyroid Neoplasms
Genetic Therapy
Prostatic Neoplasms
Thyroid Gland
Complementary DNA
Gene Expression
Therapeutics
sodium-iodide symporter
Anaplastic Thyroid Carcinoma

Keywords

  • CDNA microarray
  • Human anaplastic cancer ARO cells
  • PTP family
  • Ras oncogene family
  • Sodium/iodide symporter (NIS)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Altered gene expression profiles by sodium/iodide symporter gene transfection in a human anaplastic thyroid carcinoma cell line using a radioactive complementary dna microarray. / Choe, Jae-Gol; Kim, Yu Ri; Kim, Ki Nam; Choo, Hyo Jung; Shin, Jae Hoon; Lee, Yong Jin; Chung, June Key; Kim, Meyoung-Kon.

In: Nuclear Medicine Communications, Vol. 26, No. 12, 2005, p. 1155-1162.

Research output: Contribution to journalArticle

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