Altered right ventricular kinetic energy work density and viscous energy dissipation in patients with pulmonary arterial hypertension

A pilot study using 4D flow MRI

Q. Joyce Han, Walter R T Witschey, Christopher Fang-Yen, Jeffrey S. Arkles, Alex J. Barker, Paul R. Forfia, Yuchi Han

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction: Right ventricular (RV) function has increasingly being recognized as an important predictor for morbidity and mortality in patients with pulmonary arterial hypertension (PAH). The increased RV after-load increase RV work in PAH. We used time-resolved 3D phase contrast MRI (4D flow MRI) to derive RV kinetic energy (KE) work density and energy loss in the pulmonary artery (PA) to better characterize RV work in PAH patients. Methods: 4D flow and standard cardiac cine images were obtained in ten functional class I/II patients with PAH and nine healthy subjects. For each individual, we calculated the RV KE work density and the amount of viscous dissipation in the PA. Results: PAH patients had alterations in flow patterns in both the RV and the PA compared to healthy subjects. PAH subjects had significantly higher RV KE work density than healthy subjects (94.7±33.7 mJ/mL vs. 61.7±14.8 mJ/mL, p = 0.007) as well as a much greater percent PA energy loss (21.1 ±6.4% vs. 2.2±1.3%, p = 0.0001) throughout the cardiac cycle. RVKE work density and percent PA energy loss had mild and moderate correlations with RV ejection fraction. Conclusion: This study has quantified two kinetic energy metrics to assess RV function using 4D flow. RV KE work density and PA viscous energy loss not only distinguished healthy subjects from patients, but also provided distinction amongst PAH patients. These metrics hold promise as imaging markers for RV function.

Original languageEnglish
Article numbere0138365
JournalPLoS One
Volume10
Issue number9
DOIs
Publication statusPublished - 2015 Sep 29
Externally publishedYes

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Pulmonary Hypertension
Kinetic energy
Magnetic resonance imaging
hypertension
Energy dissipation
Pulmonary Artery
pulmonary artery
lungs
kinetics
energy
Right Ventricular Function
Healthy Volunteers
Flow patterns
Stroke Volume
Imaging techniques
morbidity
Morbidity
Mortality
image analysis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Altered right ventricular kinetic energy work density and viscous energy dissipation in patients with pulmonary arterial hypertension : A pilot study using 4D flow MRI. / Han, Q. Joyce; Witschey, Walter R T; Fang-Yen, Christopher; Arkles, Jeffrey S.; Barker, Alex J.; Forfia, Paul R.; Han, Yuchi.

In: PLoS One, Vol. 10, No. 9, e0138365, 29.09.2015.

Research output: Contribution to journalArticle

Han, Q. Joyce ; Witschey, Walter R T ; Fang-Yen, Christopher ; Arkles, Jeffrey S. ; Barker, Alex J. ; Forfia, Paul R. ; Han, Yuchi. / Altered right ventricular kinetic energy work density and viscous energy dissipation in patients with pulmonary arterial hypertension : A pilot study using 4D flow MRI. In: PLoS One. 2015 ; Vol. 10, No. 9.
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