Abstract
Recently, an increasing body of evidence suggests that developmental abnormalities related to schizophrenia may occur as early as the neonatal stage. Impairments of brain gray matter and wiring problems of axonal fibers are commonly suspected to be responsible for the disconnection hypothesis in schizophrenia adults, but significantly less is known in neonates. In this study, we investigated 26 neonates who were at genetic risk for schizophrenia and 26 demographically matched healthy neonates using both morphological and white matter networks to examine possible brain connectivity abnormalities. The results showed that both populations exhibited small-world network topology. Morphological network analysis indicated that the brain structural associations of the high-risk neonates tended to have globally lower efficiency, longer connection distance, and less number of hub nodes and edges with relatively higher betweenness. Subgroup analysis showed that male neonates were significantly disease-affected, while the female neonates were not. White matter network analysis, however, showed that the fiber networks were globally unaffected, although several subcortical-cortical connections had significantly less number of fibers in high-risk neonates. This study provides new lines of evidence in support of the disconnection hypothesis, reinforcing the notion that the genetic risk of schizophrenia induces alterations in both gray matter structural associations and white matter connectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 1622-1633 |
| Number of pages | 12 |
| Journal | NeuroImage |
| Volume | 62 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2012 Sep 1 |
| Externally published | Yes |
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Keywords
- Brain evelopment
- Diffusion tensor imaging
- High genetic risk
- Network analysis
- Newborn infant
- Schizophrenia
ASJC Scopus subject areas
- Cognitive Neuroscience
- Neurology
Cite this
Altered structural connectivity in neonates at genetic risk for schizophrenia : A combined study using morphological and white matter networks. / Shi, Feng; Yap, Pew Thian; Gao, Wei; Lin, Weili; Gilmore, John H.; Shen, Dinggang.
In: NeuroImage, Vol. 62, No. 3, 01.09.2012, p. 1622-1633.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered structural connectivity in neonates at genetic risk for schizophrenia
T2 - A combined study using morphological and white matter networks
AU - Shi, Feng
AU - Yap, Pew Thian
AU - Gao, Wei
AU - Lin, Weili
AU - Gilmore, John H.
AU - Shen, Dinggang
PY - 2012/9/1
Y1 - 2012/9/1
N2 - Recently, an increasing body of evidence suggests that developmental abnormalities related to schizophrenia may occur as early as the neonatal stage. Impairments of brain gray matter and wiring problems of axonal fibers are commonly suspected to be responsible for the disconnection hypothesis in schizophrenia adults, but significantly less is known in neonates. In this study, we investigated 26 neonates who were at genetic risk for schizophrenia and 26 demographically matched healthy neonates using both morphological and white matter networks to examine possible brain connectivity abnormalities. The results showed that both populations exhibited small-world network topology. Morphological network analysis indicated that the brain structural associations of the high-risk neonates tended to have globally lower efficiency, longer connection distance, and less number of hub nodes and edges with relatively higher betweenness. Subgroup analysis showed that male neonates were significantly disease-affected, while the female neonates were not. White matter network analysis, however, showed that the fiber networks were globally unaffected, although several subcortical-cortical connections had significantly less number of fibers in high-risk neonates. This study provides new lines of evidence in support of the disconnection hypothesis, reinforcing the notion that the genetic risk of schizophrenia induces alterations in both gray matter structural associations and white matter connectivity.
AB - Recently, an increasing body of evidence suggests that developmental abnormalities related to schizophrenia may occur as early as the neonatal stage. Impairments of brain gray matter and wiring problems of axonal fibers are commonly suspected to be responsible for the disconnection hypothesis in schizophrenia adults, but significantly less is known in neonates. In this study, we investigated 26 neonates who were at genetic risk for schizophrenia and 26 demographically matched healthy neonates using both morphological and white matter networks to examine possible brain connectivity abnormalities. The results showed that both populations exhibited small-world network topology. Morphological network analysis indicated that the brain structural associations of the high-risk neonates tended to have globally lower efficiency, longer connection distance, and less number of hub nodes and edges with relatively higher betweenness. Subgroup analysis showed that male neonates were significantly disease-affected, while the female neonates were not. White matter network analysis, however, showed that the fiber networks were globally unaffected, although several subcortical-cortical connections had significantly less number of fibers in high-risk neonates. This study provides new lines of evidence in support of the disconnection hypothesis, reinforcing the notion that the genetic risk of schizophrenia induces alterations in both gray matter structural associations and white matter connectivity.
KW - Brain evelopment
KW - Diffusion tensor imaging
KW - High genetic risk
KW - Network analysis
KW - Newborn infant
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=84863522528&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863522528&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2012.05.026
DO - 10.1016/j.neuroimage.2012.05.026
M3 - Article
C2 - 22613620
AN - SCOPUS:84863522528
VL - 62
SP - 1622
EP - 1633
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 3
ER -