Aminoquinoline derivatives with antiproliferative activity against melanoma cell line

Bong Soo Nam, Hwan Kim, Chang Hyun Oh, So Ha Lee, Seung Joo Cho, Tae Bo Sim, Jung Mi Hah, Dong Jin Kim, Jung Hoon Choi, Kyung Ho Yoo

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The synthesis of a novel series of aminoquinoline derivatives 1a-p and their antiproliferative activities against A375 human melanoma cell line were described. Most compounds showed superior antiproliferative activities to Sorafenib as a reference compound. Among them, quinolinyloxymethylphenyl compounds 1k and 1l exhibited potent activities (IC50 = 0.77 and 0.79 μM, respectively) and excellent selectivity against melanoma and fibroblast cell lines.

Original languageEnglish
Pages (from-to)3517-3520
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number13
DOIs
Publication statusPublished - 2009 Jul 1

Keywords

  • Aminoquinolines
  • Antiproliferative activity
  • Fibroblast cell line
  • Melanoma cell line
  • Selectivity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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