Amiodarone offsets the cardioprotective effects of ishaemic preconditioning against ischaemia/reperfusion injury

E. H. Koo, Y. C. Park, S. H. Lim, H. Z. Kim

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Both ischaemic preconditioning (IPC) and amiodarone protect against myocardial ischaemia. We examined whether a combination of IPC and amiodarone demonstrated an additive protective effect in isolated rat hearts (n = 40). The controls (group I) were subjected to ischaemia/ reperfusion injury; group II was subjected to cycles of IPC prior to ischaemia/reperfusion injury; group III was subjected to ischaemia in the presence of amiodarone (10-10 mol/l); and group IV was subjected to IPC followed by ischaemia in the presence of amiodarone (10-10 mol/l). Amiodarone produced the best preserved left ventricular end-systolic pressure and dP/dtmax, less developed ventricular stiffness, the shortest arrhythmia duration, and the smallest infarct size among the groups. All of the myocardial protective effects against ischaemia/ reperfusion injury were diminished or abolished when IPC and amiodarone were applied sequentially.

    Original languageEnglish
    Pages (from-to)140-151
    Number of pages12
    JournalJournal of International Medical Research
    Volume34
    Issue number2
    DOIs
    Publication statusPublished - 2006

    Keywords

    • Amiodarone
    • Anti-arrhythmic agent
    • Cardioprotection
    • Ischaemia/reperfusion injury
    • Ischaemic heart disease
    • Ischaemic preconditioning

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Biochemistry, medical

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