Amiodarone offsets the cardioprotective effects of ishaemic preconditioning against ischaemia/reperfusion injury

E. H. Koo, Y. C. Park, S. H. Lim, H. Z. Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Both ischaemic preconditioning (IPC) and amiodarone protect against myocardial ischaemia. We examined whether a combination of IPC and amiodarone demonstrated an additive protective effect in isolated rat hearts (n = 40). The controls (group I) were subjected to ischaemia/ reperfusion injury; group II was subjected to cycles of IPC prior to ischaemia/reperfusion injury; group III was subjected to ischaemia in the presence of amiodarone (10-10 mol/l); and group IV was subjected to IPC followed by ischaemia in the presence of amiodarone (10-10 mol/l). Amiodarone produced the best preserved left ventricular end-systolic pressure and dP/dtmax, less developed ventricular stiffness, the shortest arrhythmia duration, and the smallest infarct size among the groups. All of the myocardial protective effects against ischaemia/ reperfusion injury were diminished or abolished when IPC and amiodarone were applied sequentially.

Original languageEnglish
Pages (from-to)140-151
Number of pages12
JournalJournal of International Medical Research
Volume34
Issue number2
DOIs
Publication statusPublished - 2006

Keywords

  • Amiodarone
  • Anti-arrhythmic agent
  • Cardioprotection
  • Ischaemia/reperfusion injury
  • Ischaemic heart disease
  • Ischaemic preconditioning

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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