AMP-activated protein kinase: Implications on ischemic diseases

Yong Joo Ahn, Hwewon Kim, Heejin Lim, Max Lee, Yuhyun Kang, Sang Jun Moon, Hyeon Soo Kim, Hyung Hwan Kim

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Ischemia is a blockage of blood supply due to an embolism or a hemorrhage in a blood vessel. When an organ cannot receive oxygenated blood and can therefore no longer replenish its blood supply dueto ischemia, stresses, such as the disruption of blood glucose homeostasis, hypoglycemia and hypoxia, activate the AMPK complex. LKB1 and CaMKKβ are essential activators of the AMPK signaling pathway. AMPK triggers proangiogenic effects through the eNOS protein in tissues with ischemic conditions, where cells are vulnerable to apoptosis, autophagy and necrosis. The AMPK complex acts to restore blood glucose levels and ATP levels back to homeostasis. This review will discuss AMPK, as well as its key activators (LKB1 and CaMKKβ), as a central energy regulator and evaluate the upstream and downstream regulating pathways of AMPK. We will also discuss how we can control this important enzyme in ischemic conditions to prevent harmful effects in patients with vascular damage.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalBMB reports
Volume45
Issue number9
DOIs
Publication statusPublished - 2012 Dec 27

Keywords

  • AMPK
  • CaMKKβ
  • Ischemia
  • LKB1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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  • Cite this

    Ahn, Y. J., Kim, H., Lim, H., Lee, M., Kang, Y., Moon, S. J., Kim, H. S., & Kim, H. H. (2012). AMP-activated protein kinase: Implications on ischemic diseases. BMB reports, 45(9), 489-495. https://doi.org/10.5483/BMBRep.2012.45.9.169